5JK8
Phenylalanine hydroxylase from dictyostelium - BH2, norleucine complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0004505 | molecular_function | phenylalanine 4-monooxygenase activity |
| A | 0004510 | molecular_function | tryptophan 5-monooxygenase activity |
| A | 0004664 | molecular_function | prephenate dehydratase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005575 | cellular_component | cellular_component |
| A | 0006559 | biological_process | L-phenylalanine catabolic process |
| A | 0006571 | biological_process | tyrosine biosynthetic process |
| A | 0009072 | biological_process | aromatic amino acid metabolic process |
| A | 0009094 | biological_process | L-phenylalanine biosynthetic process |
| A | 0016714 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen |
| A | 0019293 | biological_process | tyrosine biosynthetic process, by oxidation of phenylalanine |
| A | 0019954 | biological_process | asexual reproduction |
| A | 0034617 | molecular_function | tetrahydrobiopterin binding |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004497 | molecular_function | monooxygenase activity |
| B | 0004505 | molecular_function | phenylalanine 4-monooxygenase activity |
| B | 0004510 | molecular_function | tryptophan 5-monooxygenase activity |
| B | 0004664 | molecular_function | prephenate dehydratase activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0005575 | cellular_component | cellular_component |
| B | 0006559 | biological_process | L-phenylalanine catabolic process |
| B | 0006571 | biological_process | tyrosine biosynthetic process |
| B | 0009072 | biological_process | aromatic amino acid metabolic process |
| B | 0009094 | biological_process | L-phenylalanine biosynthetic process |
| B | 0016714 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen |
| B | 0019293 | biological_process | tyrosine biosynthetic process, by oxidation of phenylalanine |
| B | 0019954 | biological_process | asexual reproduction |
| B | 0034617 | molecular_function | tetrahydrobiopterin binding |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue PIN A 701 |
| Chain | Residue |
| A | THR226 |
| A | ARG249 |
| A | ASP289 |
| A | LYS384 |
| A | ARG388 |
| B | LYS58 |
| B | ASN403 |
| B | TYR405 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue HBI A 702 |
| Chain | Residue |
| A | LEU236 |
| A | LEU237 |
| A | ALA239 |
| A | PHE242 |
| A | SER310 |
| A | TYR313 |
| A | HOH801 |
| A | HOH802 |
| A | GLY235 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue FE A 703 |
| Chain | Residue |
| A | HIS273 |
| A | HIS278 |
| A | GLU318 |
| A | HOH801 |
| A | HOH802 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue NLE A 704 |
| Chain | Residue |
| A | ARG258 |
| A | TYR265 |
| A | THR266 |
| A | HIS273 |
| A | GLY334 |
| A | SER337 |
| A | SER338 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue PIN B 501 |
| Chain | Residue |
| A | LYS58 |
| A | TYR405 |
| B | CYS225 |
| B | THR226 |
| B | ARG249 |
| B | PRO285 |
| B | ASP289 |
| B | LYS384 |
| B | ARG388 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | binding site for residue HBI B 502 |
| Chain | Residue |
| B | VAL233 |
| B | GLY235 |
| B | LEU236 |
| B | LEU237 |
| B | ALA239 |
| B | PHE242 |
| B | SER310 |
| B | TYR313 |
| B | HOH601 |
| B | HOH603 |
| B | HOH608 |
| B | HOH622 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue FE B 503 |
| Chain | Residue |
| B | HIS273 |
| B | HIS278 |
| B | GLU318 |
| B | HOH601 |
| B | HOH608 |
| B | HOH622 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue NLE B 504 |
| Chain | Residue |
| B | ARG258 |
| B | TYR265 |
| B | THR266 |
| B | HIS273 |
| B | GLY334 |
| B | SER337 |
| B | SER338 |
Functional Information from PROSITE/UniProt
| site_id | PS00367 |
| Number of Residues | 12 |
| Details | BH4_AAA_HYDROXYL_1 Biopterin-dependent aromatic amino acid hydroxylases signature. PDccHELLGHVP |
| Chain | Residue | Details |
| A | PRO269-PRO280 |
| site_id | PS00858 |
| Number of Residues | 8 |
| Details | PREPHENATE_DEHYDR_2 Prephenate dehydratase signature 2. ITRIESRP |
| Chain | Residue | Details |
| A | ILE49-PRO56 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | HIS273 | |
| A | HIS278 | |
| A | GLU318 | |
| B | HIS273 | |
| B | HIS278 | |
| B | GLU318 |
