5JJS

Dengue 3 NS5 protein with compound 27

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
A	0004483	molecular_function	methyltransferase cap1 activity
A	0005524	molecular_function	ATP binding
A	0008168	molecular_function	methyltransferase activity
A	0032259	biological_process	methylation
A	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1001

Chain	Residue
A	GLU437
A	HIS441
A	CYS446
A	CYS449

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1002

Chain	Residue
A	HIS712
A	HIS714
A	CYS728
A	CYS847

---

site_id	AC3
Number of Residues	7
Details	binding site for residue PEG A 1003

Chain	Residue
A	CYS393
A	THR394
A	ARG438
A	TYR482
A	GLU486
A	HOH1504
A	TYR134

---

site_id	AC4
Number of Residues	18
Details	binding site for residue 6L2 A 1004

Chain	Residue
A	LEU511
A	HIS512
A	CYS709
A	SER710
A	HIS711
A	ARG729
A	ARG737
A	TYR766
A	THR794
A	TRP795
A	SER796
A	HIS798
A	HIS800
A	GLN802
A	TRP803
A	HOH1336
A	HOH1380
A	HOH1540

---

site_id	AC5
Number of Residues	6
Details	binding site for residue MG A 1005

Chain	Residue
A	ASP533
A	ASP664
A	HOH1218
A	HOH1256
A	HOH1325
A	HOH1346

---

site_id	AC6
Number of Residues	10
Details	binding site for residue PEG A 1006

Chain	Residue
A	TYR119
A	ASP256
A	LEU257
A	GLY258
A	LYS300
A	LYS355
A	GLU356
A	ASP359
A	THR360
A	HOH1163

---

site_id	AC7
Number of Residues	4
Details	binding site for residue EDO A 1007

Chain	Residue
A	LYS14
A	ASN18
A	PRO152
A	HOH1291

---

site_id	AC8
Number of Residues	6
Details	binding site for residue EDO A 1008

Chain	Residue
A	ARG57
A	LYS61
A	LEU209
A	HOH1206
A	HOH1436
A	HOH1501

---

site_id	AC9
Number of Residues	18
Details	binding site for residue SAH A 1009

Chain	Residue
A	SER56
A	GLY58
A	GLY81
A	CYS82
A	GLY83
A	GLY86
A	TRP87
A	THR104
A	LYS105
A	HIS110
A	GLU111
A	ASP131
A	VAL132
A	PHE133
A	ASP146
A	HOH1174
A	HOH1183
A	HOH1220

---

site_id	AD1
Number of Residues	4
Details	binding site for residue EDO A 1010

Chain	Residue
A	ARG499
A	LYS656
A	HOH1132
A	HOH1248

---

site_id	AD2
Number of Residues	5
Details	binding site for residue EDO A 1011

Chain	Residue
A	GLU7
A	GLU11
A	LYS15
A	ASN835
A	HOH1441

---

site_id	AD3
Number of Residues	7
Details	binding site for residue PEG A 1012

Chain	Residue
A	GLN351
A	ARG352
A	LYS355
A	EDO1013
A	HOH1113
A	HOH1187
A	HOH1708

---

site_id	AD4
Number of Residues	6
Details	binding site for residue EDO A 1013

Chain	Residue
A	ASN69
A	PRO298
A	GLN351
A	ARG581
A	PEG1012
A	HOH1608

---

site_id	AD5
Number of Residues	2
Details	binding site for residue EDO A 1014

Chain	Residue
A	LYS630
A	TRP694

---

site_id	AD6
Number of Residues	7
Details	binding site for residue PEG A 1015

Chain	Residue
A	GLY6
A	GLU7
A	LYS719
A	ASP720
A	ILE874
A	GLY875
A	ASN876

---

site_id	AD7
Number of Residues	7
Details	binding site for residue EDO A 1016

Chain	Residue
A	PHE485
A	GLY489
A	ASN492
A	GLU493
A	VAL603
A	HOH1102
A	HOH1392

---

site_id	AD8
Number of Residues	5
Details	binding site for residue EDO A 1017

Chain	Residue
A	SER710
A	HIS711
A	HIS712
A	HOH1131
A	HOH1338

---

site_id	AD9
Number of Residues	3
Details	binding site for residue EDO A 1018

Chain	Residue
A	HIS714
A	HOH1116
A	HOH1494

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	150
Details	Domain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Motif: {"description":"SUMO-interacting motif","evidences":[{"source":"UniProtKB","id":"P29990","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"For 2'-O-MTase activity","evidences":[{"source":"PubMed","id":"26578813","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17301146","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	7
Details	Site: {"description":"mRNA cap binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Site: {"description":"mRNA cap binding; via carbonyl oxygen","evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	Site: {"description":"Essential for 2'-O-methyltransferase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Site: {"description":"Essential for 2'-O-methyltransferase and N-7 methyltransferase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P03314","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---