Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 501 |
| Chain | Residue |
| A | ASP60 |
| A | HOH618 |
| A | HOH635 |
| A | HOH637 |
| A | HOH638 |
| A | HOH664 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 502 |
| Chain | Residue |
| B | ARG41 |
| A | THR74 |
| A | ASN88 |
| A | HOH673 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 503 |
| Chain | Residue |
| A | LEU5 |
| A | HOH606 |
| B | THR91 |
| B | ALA95 |
| B | THR96 |
| B | HOH336 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | binding site for residue 6KR B 201 |
| Chain | Residue |
| A | ARG8 |
| A | ASP25 |
| A | GLY27 |
| A | ALA28 |
| A | ASP30 |
| A | GLY48 |
| A | GLY49 |
| A | VAL82 |
| A | ILE84 |
| B | ASP25 |
| B | GLY27 |
| B | ALA28 |
| B | ASP29 |
| B | ASP30 |
| B | GLY48 |
| B | ILE50 |
| B | HOH342 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue NA B 202 |
| Chain | Residue |
| B | ASP60 |
| B | HOH325 |
| B | HOH345 |
| B | HOH370 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue NA B 203 |
| Chain | Residue |
| B | HOH310 |
| B | HOH326 |
| B | HOH329 |
| B | HOH341 |
| B | HOH389 |
| B | HOH404 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 204 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI |
| Chain | Residue | Details |
| A | ALA22-ILE33 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 138 |
| Details | Domain: {"description":"Peptidase A2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00275","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Region: {"description":"Dimerization of protease","evidences":[{"source":"UniProtKB","id":"P04585","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For protease activity; shared with dimeric partner","evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12924029","evidenceCode":"ECO:0000269"}]} |
