5JD4
Crystal structure of LAE6 Ser161Ala mutant, an alpha/beta hydrolase enzyme from the metagenome of Lake Arreo, Spain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016787 | molecular_function | hydrolase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| E | 0016787 | molecular_function | hydrolase activity |
| F | 0016787 | molecular_function | hydrolase activity |
| G | 0016787 | molecular_function | hydrolase activity |
| H | 0016787 | molecular_function | hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 401 |
| Chain | Residue |
| A | LYS275 |
| A | HIS312 |
| A | HOH552 |
| H | GLN297 |
| H | LYS300 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 402 |
| Chain | Residue |
| H | ARG263 |
| H | ASP267 |
| H | ILE270 |
| A | ARG263 |
| A | ASP267 |
| A | ILE270 |
| A | TYR278 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | GLN-1 |
| A | LEU10 |
| A | ASP11 |
| A | ASP14 |
| A | GLY207 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 404 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 405 |
| Chain | Residue |
| A | GLU52 |
| A | ARG69 |
| A | ARG71 |
| A | GLY78 |
| A | HOH501 |
| A | HOH533 |
| C | ARG69 |
| C | SER147 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue PE3 A 406 |
| Chain | Residue |
| A | ARG105 |
| A | LEU299 |
| A | HOH562 |
| B | GLY19 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue BEN A 407 |
| Chain | Residue |
| A | GLY89 |
| A | GLY90 |
| A | ALA161 |
| A | ALA162 |
| A | LEU210 |
| A | MET215 |
| A | HIS286 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 401 |
| Chain | Residue |
| B | GLN297 |
| B | LYS300 |
| B | HOH539 |
| E | LYS275 |
| E | HIS312 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 402 |
| Chain | Residue |
| B | LYS275 |
| B | HIS312 |
| B | HOH529 |
| E | GLN297 |
| E | LYS300 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 403 |
| Chain | Residue |
| B | GLU25 |
| B | LEU27 |
| B | CL404 |
| B | HOH614 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 404 |
| Chain | Residue |
| B | HIS29 |
| B | GOL403 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 405 |
| Chain | Residue |
| B | GLN-1 |
| B | ASP11 |
| B | GLY207 |
| B | HOH516 |
| B | HOH659 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 406 |
| Chain | Residue |
| B | ARG69 |
| B | ARG71 |
| B | GLY78 |
| B | SER147 |
| D | ARG69 |
| D | GLU146 |
| D | SER147 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 407 |
| Chain | Residue |
| B | ARG21 |
| B | PRO22 |
| B | ALA35 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue BEN B 408 |
| Chain | Residue |
| B | GLY88 |
| B | GLY89 |
| B | GLY90 |
| B | ALA161 |
| B | ALA162 |
| B | HIS286 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 C 401 |
| Chain | Residue |
| C | LYS275 |
| C | HIS312 |
| C | HOH505 |
| F | GLN297 |
| F | LYS300 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 C 402 |
| Chain | Residue |
| C | GLN297 |
| C | LYS300 |
| C | HOH508 |
| C | HOH571 |
| F | LYS275 |
| F | HIS312 |
| site_id | AD9 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 403 |
| Chain | Residue |
| A | ASN55 |
| A | ARG66 |
| C | GLU49 |
| C | VAL50 |
| C | VAL53 |
| C | ARG104 |
| C | HOH516 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 404 |
| Chain | Residue |
| C | ALA62 |
| C | ARG120 |
| C | ALA129 |
| C | ASP132 |
| C | HOH503 |
| C | HOH559 |
| site_id | AE2 |
| Number of Residues | 7 |
| Details | binding site for residue BEN C 406 |
| Chain | Residue |
| C | GLY89 |
| C | GLY90 |
| C | ALA161 |
| C | ALA162 |
| C | LEU210 |
| C | HIS286 |
| C | GLY88 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 D 401 |
| Chain | Residue |
| D | LYS275 |
| D | HIS312 |
| D | HOH522 |
| D | HOH613 |
| G | GLN297 |
| G | LYS300 |
| site_id | AE4 |
| Number of Residues | 3 |
| Details | binding site for residue GOL D 402 |
| Chain | Residue |
| D | ARG21 |
| D | PRO22 |
| D | MET39 |
| site_id | AE5 |
| Number of Residues | 3 |
| Details | binding site for residue CL D 403 |
| Chain | Residue |
| D | HIS29 |
| D | GOL404 |
| D | HOH555 |
| site_id | AE6 |
| Number of Residues | 9 |
| Details | binding site for residue GOL D 404 |
| Chain | Residue |
| D | GLU25 |
| D | LEU27 |
| D | PRO28 |
| D | HIS29 |
| D | TRP217 |
| D | CL403 |
| D | HOH541 |
| D | HOH555 |
| D | HOH736 |
| site_id | AE7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL D 405 |
| Chain | Residue |
| D | GLN-1 |
| D | ARG7 |
| D | LEU10 |
| D | ASP11 |
| D | GLY207 |
| site_id | AE8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL D 406 |
| Chain | Residue |
| D | ALA62 |
| D | ARG120 |
| D | ALA129 |
| D | ASP132 |
| D | HOH595 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue CL D 407 |
| Chain | Residue |
| D | ASP231 |
| D | LEU232 |
| D | HOH750 |
| D | HOH785 |
| site_id | AF1 |
| Number of Residues | 9 |
| Details | binding site for residue PE3 D 408 |
| Chain | Residue |
| C | ALA45 |
| C | THR292 |
| C | ARG293 |
| C | HOH565 |
| D | LEU12 |
| D | ARG21 |
| D | MET39 |
| D | PHE209 |
| D | HOH647 |
| site_id | AF2 |
| Number of Residues | 7 |
| Details | binding site for residue BEN D 409 |
| Chain | Residue |
| D | GLY89 |
| D | GLY90 |
| D | ALA161 |
| D | ALA162 |
| D | LEU210 |
| D | MET215 |
| D | HIS286 |
| site_id | AF3 |
| Number of Residues | 1 |
| Details | binding site for residue CL E 401 |
| site_id | AF4 |
| Number of Residues | 8 |
| Details | binding site for residue GOL E 402 |
| Chain | Residue |
| E | GLU49 |
| E | VAL50 |
| E | VAL53 |
| E | ARG104 |
| E | HOH600 |
| G | ASN55 |
| G | GLY56 |
| G | ARG66 |
| site_id | AF5 |
| Number of Residues | 2 |
| Details | binding site for residue GOL E 403 |
| Chain | Residue |
| E | ARG105 |
| E | LYS109 |
| site_id | AF6 |
| Number of Residues | 7 |
| Details | binding site for residue GOL E 404 |
| Chain | Residue |
| E | ASN55 |
| E | GLY56 |
| E | ARG66 |
| E | PHE67 |
| E | ARG68 |
| E | ILE96 |
| E | GLU97 |
| site_id | AF7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL E 405 |
| Chain | Residue |
| E | GLN-1 |
| E | ARG7 |
| E | ASP11 |
| E | GLY207 |
| E | HOH647 |
| site_id | AF8 |
| Number of Residues | 5 |
| Details | binding site for residue BEN E 406 |
| Chain | Residue |
| E | GLY89 |
| E | GLY90 |
| E | ALA161 |
| E | ALA162 |
| E | HIS286 |
| site_id | AF9 |
| Number of Residues | 7 |
| Details | binding site for residue GOL F 401 |
| Chain | Residue |
| C | ARG263 |
| C | ASP267 |
| C | ILE270 |
| F | ARG263 |
| F | ASP267 |
| F | ILE270 |
| F | TYR278 |
| site_id | AG1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL F 402 |
| Chain | Residue |
| F | GLU49 |
| F | VAL50 |
| F | VAL53 |
| F | ARG104 |
| site_id | AG2 |
| Number of Residues | 3 |
| Details | binding site for residue GOL F 403 |
| Chain | Residue |
| F | GLY207 |
| F | HOH506 |
| F | HOH636 |
| site_id | AG3 |
| Number of Residues | 2 |
| Details | binding site for residue CL F 404 |
| Chain | Residue |
| F | ARG105 |
| F | HOH673 |
| site_id | AG4 |
| Number of Residues | 8 |
| Details | binding site for residue BEN F 405 |
| Chain | Residue |
| F | GLY88 |
| F | GLY89 |
| F | GLY90 |
| F | ALA161 |
| F | ALA162 |
| F | MET215 |
| F | HIS286 |
| F | HOH790 |
| site_id | AG5 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 G 401 |
| Chain | Residue |
| D | GLN297 |
| D | LYS300 |
| G | LYS275 |
| G | HIS312 |
| G | HOH557 |
| G | HOH583 |
| site_id | AG6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL G 402 |
| Chain | Residue |
| E | ASN55 |
| E | ARG66 |
| G | GLU49 |
| G | VAL50 |
| G | VAL53 |
| G | ARG104 |
| site_id | AG7 |
| Number of Residues | 2 |
| Details | binding site for residue GOL G 403 |
| Chain | Residue |
| G | ARG105 |
| G | LYS109 |
| site_id | AG8 |
| Number of Residues | 1 |
| Details | binding site for residue CL G 404 |
| site_id | AG9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL G 405 |
| Chain | Residue |
| G | GLN-1 |
| G | LEU2 |
| G | ASP11 |
| G | GLY207 |
| G | HOH511 |
| site_id | AH1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL G 406 |
| Chain | Residue |
| E | LEU79 |
| E | GLU146 |
| G | LEU79 |
| G | GLU146 |
| G | HOH594 |
| site_id | AH2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL G 407 |
| Chain | Residue |
| D | ILE270 |
| G | ARG259 |
| G | ASP260 |
| G | ARG263 |
| G | HOH647 |
| site_id | AH3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL G 408 |
| Chain | Residue |
| D | ARG263 |
| D | ASP267 |
| G | ARG263 |
| G | ASP267 |
| G | ILE270 |
| G | TYR278 |
| site_id | AH4 |
| Number of Residues | 6 |
| Details | binding site for residue BEN G 409 |
| Chain | Residue |
| G | GLY88 |
| G | GLY89 |
| G | GLY90 |
| G | ALA161 |
| G | ALA162 |
| G | HIS286 |
| site_id | AH5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 H 401 |
| Chain | Residue |
| A | GLN297 |
| A | LYS300 |
| H | LYS275 |
| H | HIS312 |
| H | HOH548 |
| site_id | AH6 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 H 402 |
| Chain | Residue |
| H | ARG105 |
| H | GOL403 |
| site_id | AH7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL H 403 |
| Chain | Residue |
| A | GLY314 |
| A | HOH528 |
| H | SER296 |
| H | LEU299 |
| H | SO4402 |
| H | HOH583 |
| H | HOH632 |
| site_id | AH8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL H 404 |
| Chain | Residue |
| H | ARG175 |
| H | LEU232 |
| H | ALA239 |
| H | THR240 |
| H | ASP241 |
| site_id | AH9 |
| Number of Residues | 5 |
| Details | binding site for residue PE3 H 405 |
| Chain | Residue |
| A | ILE270 |
| H | ARG259 |
| H | ASP260 |
| H | ARG263 |
| H | ASN280 |
| site_id | AI1 |
| Number of Residues | 6 |
| Details | binding site for residue BEN H 406 |
| Chain | Residue |
| H | GLY89 |
| H | GLY90 |
| H | ALA161 |
| H | ALA162 |
| H | MET215 |
| H | HIS286 |
