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5JC3

Crystal structure of chicken MDA5 with 5'p 10-mer dsRNA and ADP-Mg2+ at 2.6 A resolution (monoclinic form, twinned).

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0005524molecular_functionATP binding
A0016787molecular_functionhydrolase activity
B0003677molecular_functionDNA binding
B0005524molecular_functionATP binding
B0016787molecular_functionhydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues12
Detailsbinding site for residue ADP A 1001
ChainResidue
ATHR300
AGLU369
AARG798
AMG1002
AARG302
AGLN305
ATHR324
AGLY325
ASER326
AGLY327
ALYS328
AARG330

site_idAC2
Number of Residues2
Detailsbinding site for residue MG A 1002
ChainResidue
ATHR329
AADP1001

site_idAC3
Number of Residues4
Detailsbinding site for residue ZN A 1003
ChainResidue
ACYS881
ACYS884
ACYS936
ACYS939

site_idAC4
Number of Residues13
Detailsbinding site for residue ADP B 1001
ChainResidue
BTHR300
BARG302
BGLN305
BPRO323
BTHR324
BGLY325
BSER326
BGLY327
BLYS328
BARG330
BGLU369
BARG798
BMG1002

site_idAC5
Number of Residues2
Detailsbinding site for residue MG B 1002
ChainResidue
BTHR329
BADP1001

site_idAC6
Number of Residues4
Detailsbinding site for residue ZN B 1003
ChainResidue
BCYS881
BCYS884
BCYS936
BCYS939

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PDB entries from 2024-11-06

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