5J9Q

Crystal structure of the NuA4 core complex

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Functional Information from GO Data

ChainGOidnamespacecontents
B0070776cellular_componentMOZ/MORF histone acetyltransferase complex
B0033100cellular_componentNuA3 histone acetyltransferase complex
B1990467cellular_componentNuA3a histone acetyltransferase complex
B1990468cellular_componentNuA3b histone acetyltransferase complex
B0035267cellular_componentNuA4 histone acetyltransferase complex
B0005730cellular_componentnucleolus
B0005634cellular_componentnucleus
B0006281biological_processDNA repair
B0016573biological_processhistone acetylation
B0043968biological_processhistone H2A acetylation
B0044154biological_processhistone H3-K14 acetylation
B0043972biological_processhistone H3-K23 acetylation
B0043983biological_processhistone H4-K12 acetylation
B0043981biological_processhistone H4-K5 acetylation
B0043982biological_processhistone H4-K8 acetylation
F0070776cellular_componentMOZ/MORF histone acetyltransferase complex
F0033100cellular_componentNuA3 histone acetyltransferase complex
F1990467cellular_componentNuA3a histone acetyltransferase complex
F1990468cellular_componentNuA3b histone acetyltransferase complex
F0035267cellular_componentNuA4 histone acetyltransferase complex
F0005730cellular_componentnucleolus
F0005634cellular_componentnucleus
F0006281biological_processDNA repair
F0016573biological_processhistone acetylation
F0043968biological_processhistone H2A acetylation
F0044154biological_processhistone H3-K14 acetylation
F0043972biological_processhistone H3-K23 acetylation
F0043983biological_processhistone H4-K12 acetylation
F0043981biological_processhistone H4-K5 acetylation
F0043982biological_processhistone H4-K8 acetylation
J0070776cellular_componentMOZ/MORF histone acetyltransferase complex
J0033100cellular_componentNuA3 histone acetyltransferase complex
J1990467cellular_componentNuA3a histone acetyltransferase complex
J1990468cellular_componentNuA3b histone acetyltransferase complex
J0035267cellular_componentNuA4 histone acetyltransferase complex
J0005730cellular_componentnucleolus
J0005634cellular_componentnucleus
J0006281biological_processDNA repair
J0016573biological_processhistone acetylation
J0043968biological_processhistone H2A acetylation
J0044154biological_processhistone H3-K14 acetylation
J0043972biological_processhistone H3-K23 acetylation
J0043983biological_processhistone H4-K12 acetylation
J0043981biological_processhistone H4-K5 acetylation
J0043982biological_processhistone H4-K8 acetylation
C0035267cellular_componentNuA4 histone acetyltransferase complex
C0032777cellular_componentPiccolo NuA4 histone acetyltransferase complex
C0007049biological_processcell cycle
C0006281biological_processDNA repair
C0016573biological_processhistone acetylation
C0016239biological_processpositive regulation of macroautophagy
C0006357biological_processregulation of transcription by RNA polymerase II
G0035267cellular_componentNuA4 histone acetyltransferase complex
G0032777cellular_componentPiccolo NuA4 histone acetyltransferase complex
G0007049biological_processcell cycle
G0006281biological_processDNA repair
G0016573biological_processhistone acetylation
G0016239biological_processpositive regulation of macroautophagy
G0006357biological_processregulation of transcription by RNA polymerase II
N0035267cellular_componentNuA4 histone acetyltransferase complex
N0032777cellular_componentPiccolo NuA4 histone acetyltransferase complex
N0007049biological_processcell cycle
N0006281biological_processDNA repair
N0016573biological_processhistone acetylation
N0016239biological_processpositive regulation of macroautophagy
N0006357biological_processregulation of transcription by RNA polymerase II
A0000123cellular_componenthistone acetyltransferase complex
A0035267cellular_componentNuA4 histone acetyltransferase complex
A0000790cellular_componentnuclear chromatin
A0005634cellular_componentnucleus
A0032777cellular_componentPiccolo NuA4 histone acetyltransferase complex
A0010485molecular_functionH4 histone acetyltransferase activity
A0004402molecular_functionhistone acetyltransferase activity
A0042393molecular_functionhistone binding
A0034212molecular_functionpeptide N-acetyltransferase activity
A0000183biological_processchromatin silencing at rDNA
A0006281biological_processDNA repair
A0006354biological_processDNA-templated transcription, elongation
A0016573biological_processhistone acetylation
A0001207biological_processhistone displacement
A0045892biological_processnegative regulation of transcription, DNA-templated
A0018394biological_processpeptidyl-lysine acetylation
A0016239biological_processpositive regulation of macroautophagy
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0032968biological_processpositive regulation of transcription elongation from RNA polymerase II promoter
A0051726biological_processregulation of cell cycle
A0006357biological_processregulation of transcription by RNA polymerase II
E0000123cellular_componenthistone acetyltransferase complex
E0035267cellular_componentNuA4 histone acetyltransferase complex
E0000790cellular_componentnuclear chromatin
E0005634cellular_componentnucleus
E0032777cellular_componentPiccolo NuA4 histone acetyltransferase complex
E0010485molecular_functionH4 histone acetyltransferase activity
E0004402molecular_functionhistone acetyltransferase activity
E0042393molecular_functionhistone binding
E0034212molecular_functionpeptide N-acetyltransferase activity
E0000183biological_processchromatin silencing at rDNA
E0006281biological_processDNA repair
E0006354biological_processDNA-templated transcription, elongation
E0016573biological_processhistone acetylation
E0001207biological_processhistone displacement
E0045892biological_processnegative regulation of transcription, DNA-templated
E0018394biological_processpeptidyl-lysine acetylation
E0016239biological_processpositive regulation of macroautophagy
E0045944biological_processpositive regulation of transcription by RNA polymerase II
E0032968biological_processpositive regulation of transcription elongation from RNA polymerase II promoter
E0051726biological_processregulation of cell cycle
E0006357biological_processregulation of transcription by RNA polymerase II
I0000123cellular_componenthistone acetyltransferase complex
I0035267cellular_componentNuA4 histone acetyltransferase complex
I0000790cellular_componentnuclear chromatin
I0005634cellular_componentnucleus
I0032777cellular_componentPiccolo NuA4 histone acetyltransferase complex
I0010485molecular_functionH4 histone acetyltransferase activity
I0004402molecular_functionhistone acetyltransferase activity
I0042393molecular_functionhistone binding
I0034212molecular_functionpeptide N-acetyltransferase activity
I0000183biological_processchromatin silencing at rDNA
I0006281biological_processDNA repair
I0006354biological_processDNA-templated transcription, elongation
I0016573biological_processhistone acetylation
I0001207biological_processhistone displacement
I0045892biological_processnegative regulation of transcription, DNA-templated
I0018394biological_processpeptidyl-lysine acetylation
I0016239biological_processpositive regulation of macroautophagy
I0045944biological_processpositive regulation of transcription by RNA polymerase II
I0032968biological_processpositive regulation of transcription elongation from RNA polymerase II promoter
I0051726biological_processregulation of cell cycle
I0006357biological_processregulation of transcription by RNA polymerase II
L0000790cellular_componentnuclear chromatin
L0005719cellular_componentnuclear euchromatin
L0000786cellular_componentnucleosome
L0005634cellular_componentnucleus
L0003682molecular_functionchromatin binding
L0031490molecular_functionchromatin DNA binding
L0003677molecular_functionDNA binding
L0042802molecular_functionidentical protein binding
L0046982molecular_functionprotein heterodimerization activity
L0000978molecular_functionRNA polymerase II proximal promoter sequence-specific DNA binding
L0006325biological_processchromatin organization
L0006338biological_processchromatin remodeling
L0030466biological_processchromatin silencing at silent mating-type cassette
L0070481biological_processnuclear-transcribed mRNA catabolic process, non-stop decay
L0006357biological_processregulation of transcription by RNA polymerase II
M0000790cellular_componentnuclear chromatin
M0005719cellular_componentnuclear euchromatin
M0000786cellular_componentnucleosome
M0005634cellular_componentnucleus
M0003682molecular_functionchromatin binding
M0031490molecular_functionchromatin DNA binding
M0003677molecular_functionDNA binding
M0042802molecular_functionidentical protein binding
M0046982molecular_functionprotein heterodimerization activity
M0000978molecular_functionRNA polymerase II proximal promoter sequence-specific DNA binding
M0006325biological_processchromatin organization
M0006338biological_processchromatin remodeling
M0030466biological_processchromatin silencing at silent mating-type cassette
M0070481biological_processnuclear-transcribed mRNA catabolic process, non-stop decay
M0006357biological_processregulation of transcription by RNA polymerase II
O0000790cellular_componentnuclear chromatin
O0005719cellular_componentnuclear euchromatin
O0000786cellular_componentnucleosome
O0005634cellular_componentnucleus
O0003682molecular_functionchromatin binding
O0031490molecular_functionchromatin DNA binding
O0003677molecular_functionDNA binding
O0042802molecular_functionidentical protein binding
O0046982molecular_functionprotein heterodimerization activity
O0000978molecular_functionRNA polymerase II proximal promoter sequence-specific DNA binding
O0006325biological_processchromatin organization
O0006338biological_processchromatin remodeling
O0030466biological_processchromatin silencing at silent mating-type cassette
O0070481biological_processnuclear-transcribed mRNA catabolic process, non-stop decay
O0006357biological_processregulation of transcription by RNA polymerase II
D0005829cellular_componentcytosol
D0035267cellular_componentNuA4 histone acetyltransferase complex
D0005634cellular_componentnucleus
D0032777cellular_componentPiccolo NuA4 histone acetyltransferase complex
D0046872molecular_functionmetal ion binding
D0035064molecular_functionmethylated histone binding
D0016569biological_processcovalent chromatin modification
D0006281biological_processDNA repair
D0016573biological_processhistone acetylation
D0051321biological_processmeiotic cell cycle
H0005829cellular_componentcytosol
H0035267cellular_componentNuA4 histone acetyltransferase complex
H0005634cellular_componentnucleus
H0032777cellular_componentPiccolo NuA4 histone acetyltransferase complex
H0046872molecular_functionmetal ion binding
H0035064molecular_functionmethylated histone binding
H0016569biological_processcovalent chromatin modification
H0006281biological_processDNA repair
H0016573biological_processhistone acetylation
H0051321biological_processmeiotic cell cycle
K0005829cellular_componentcytosol
K0035267cellular_componentNuA4 histone acetyltransferase complex
K0005634cellular_componentnucleus
K0032777cellular_componentPiccolo NuA4 histone acetyltransferase complex
K0046872molecular_functionmetal ion binding
K0035064molecular_functionmethylated histone binding
K0016569biological_processcovalent chromatin modification
K0006281biological_processDNA repair
K0016573biological_processhistone acetylation
K0051321biological_processmeiotic cell cycle
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
ALY_5j9q_E_26216N(6)-ACETYLLYSINE binding site
ChainResidueligand
ECYS252ALY: N(6)-ACETYLLYSINE
ESER255-LYS256ALY: N(6)-ACETYLLYSINE
ELEU259-HIS261ALY: N(6)-ACETYLLYSINE
ETHR263-LEU264ALY: N(6)-ACETYLLYSINE
EPHE271ALY: N(6)-ACETYLLYSINE
EPHE273ALY: N(6)-ACETYLLYSINE
ETYR289ALY: N(6)-ACETYLLYSINE
ESER291ALY: N(6)-ACETYLLYSINE
ECYS304ALY: N(6)-ACETYLLYSINE
LALA3-ASP5ALY: N(6)-ACETYLLYSINE

ALY_5j9q_A_26215N(6)-ACETYLLYSINE binding site
ChainResidueligand
ACYS252ALY: N(6)-ACETYLLYSINE
ASER255-LYS256ALY: N(6)-ACETYLLYSINE
ALEU259-HIS261ALY: N(6)-ACETYLLYSINE
ATHR263-LEU264ALY: N(6)-ACETYLLYSINE
APHE271ALY: N(6)-ACETYLLYSINE
APHE273ALY: N(6)-ACETYLLYSINE
ATYR289ALY: N(6)-ACETYLLYSINE
ASER291ALY: N(6)-ACETYLLYSINE
AALA303-CYS304ALY: N(6)-ACETYLLYSINE
OALA3ALY: N(6)-ACETYLLYSINE

ALY_5j9q_I_26215N(6)-ACETYLLYSINE binding site
ChainResidueligand
ICYS252ALY: N(6)-ACETYLLYSINE
ISER255-LYS256ALY: N(6)-ACETYLLYSINE
ILEU259-HIS261ALY: N(6)-ACETYLLYSINE
ITHR263-LEU264ALY: N(6)-ACETYLLYSINE
IPHE271ALY: N(6)-ACETYLLYSINE
IPHE273ALY: N(6)-ACETYLLYSINE
ITYR289ALY: N(6)-ACETYLLYSINE
ISER291ALY: N(6)-ACETYLLYSINE
IALA303-CYS304ALY: N(6)-ACETYLLYSINE
MALA3ALY: N(6)-ACETYLLYSINE

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
SWS_FT_FI11Proton donor/acceptor. {ECO:0000303|PubMed:12368900, ECO:0000303|PubMed:17223684, ECO:0000303|PubMed:18245364, ECO:0000303|PubMed:22020126, ECO:0000305}.
ChainResidueDetails
EGLN198

SWS_FT_FI21Acetyl-CoA. {ECO:0000269|PubMed:11106757, ECO:0000269|PubMed:12368900, ECO:0000269|PubMed:22020126}.
ChainResidueDetails
ESER202

SWS_FT_FI31Important for catalytic activity. {ECO:0000305}.
ChainResidueDetails
ECYS164

SWS_FT_FI41Proton donor/acceptor. {ECO:0000303|PubMed:12368900, ECO:0000303|PubMed:17223684, ECO:0000303|PubMed:18245364, ECO:0000303|PubMed:22020126, ECO:0000305}.
ChainResidueDetails
AGLN198

SWS_FT_FI51Acetyl-CoA. {ECO:0000269|PubMed:11106757, ECO:0000269|PubMed:12368900, ECO:0000269|PubMed:22020126}.
ChainResidueDetails
ASER202

SWS_FT_FI61Important for catalytic activity. {ECO:0000305}.
ChainResidueDetails
ACYS164

SWS_FT_FI71Proton donor/acceptor. {ECO:0000303|PubMed:12368900, ECO:0000303|PubMed:17223684, ECO:0000303|PubMed:18245364, ECO:0000303|PubMed:22020126, ECO:0000305}.
ChainResidueDetails
IGLN198

SWS_FT_FI81Acetyl-CoA. {ECO:0000269|PubMed:11106757, ECO:0000269|PubMed:12368900, ECO:0000269|PubMed:22020126}.
ChainResidueDetails
ISER202

SWS_FT_FI91Important for catalytic activity. {ECO:0000305}.
ChainResidueDetails
ICYS164

SWS_FT_FI103Zinc 1. {ECO:0000250|UniProtKB:Q9UK53}
ChainResidueDetails
DNA*
DNA*
DNA*

SWS_FT_FI114Zinc 2. {ECO:0000250|UniProtKB:Q9UK53}
ChainResidueDetails
DNA*
DNA*
DNA*
DNA*

SWS_FT_FI121Zinc 1; via pros nitrogen. {ECO:0000250|UniProtKB:Q9UK53}
ChainResidueDetails
DNA*

SWS_FT_FI134Histone H3K4me3. {ECO:0000250|UniProtKB:Q9UK53}.
ChainResidueDetails
DNA*
DNA*
DNA*
DNA*

SWS_FT_FI143Zinc 1. {ECO:0000250|UniProtKB:Q9UK53}
ChainResidueDetails
HNA*
HNA*
HNA*

SWS_FT_FI154Zinc 2. {ECO:0000250|UniProtKB:Q9UK53}
ChainResidueDetails
HNA*
HNA*
HNA*
HNA*

SWS_FT_FI161Zinc 1; via pros nitrogen. {ECO:0000250|UniProtKB:Q9UK53}
ChainResidueDetails
HNA*

SWS_FT_FI174Histone H3K4me3. {ECO:0000250|UniProtKB:Q9UK53}.
ChainResidueDetails
HNA*
HNA*
HNA*
HNA*

SWS_FT_FI183Zinc 1. {ECO:0000250|UniProtKB:Q9UK53}
ChainResidueDetails
KNA*
KNA*
KNA*

SWS_FT_FI194Zinc 2. {ECO:0000250|UniProtKB:Q9UK53}
ChainResidueDetails
KNA*
KNA*
KNA*
KNA*

SWS_FT_FI201Zinc 1; via pros nitrogen. {ECO:0000250|UniProtKB:Q9UK53}
ChainResidueDetails
KNA*

SWS_FT_FI214Histone H3K4me3. {ECO:0000250|UniProtKB:Q9UK53}.
ChainResidueDetails
KNA*
KNA*
KNA*
KNA*

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Catalytic Information from CSA

site_idNumber of ResiduesDetails