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5J5R

M. thermoresistible GuaB2 delta-CBS in complex with inhibitor VCC234718

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0003938molecular_functionIMP dehydrogenase activity
A0006164biological_processpurine nucleotide biosynthetic process
A0016491molecular_functionoxidoreductase activity
Functional Information from PDB Data
site_idAC1
Number of Residues10
Detailsbinding site for residue 6G1 A 401
ChainResidue
APRO46
AIMP402
AALA145
AGLY194
AGLY196
ATHR203
AMET284
AGLY285
AGLU318
AALA343

site_idAC2
Number of Residues24
Detailsbinding site for residue IMP A 402
ChainResidue
ASER68
AMET70
AGLY198
ASER199
AILE200
ACYS201
AASP234
AGLY235
AGLY236
AGLY257
ASER258
ATYR281
AGLY283
AMET284
AGLY285
AGLU318
AGLY319
A6G1401
AHOH516
AHOH517
AHOH569
AHOH594
AHOH609
AHOH656

Functional Information from PROSITE/UniProt
site_idPS00487
Number of Residues13
DetailsIMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. VKVGVGpGSICtT
ChainResidueDetails
AVAL191-THR203

226707

PDB entries from 2024-10-30

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