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5J5D

Crystal structure of Dihydrodipicolinate Synthase from Mycobacterium tuberculosis in complex with alpha-ketopimelic acid

Functional Information from GO Data
ChainGOidnamespacecontents
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0008840molecular_function4-hydroxy-tetrahydrodipicolinate synthase activity
A0009085biological_processlysine biosynthetic process
A0009089biological_processlysine biosynthetic process via diaminopimelate
A0016829molecular_functionlyase activity
A0019877biological_processdiaminopimelate biosynthetic process
A0044281biological_processsmall molecule metabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue NA A 401
ChainResidue
APRO152
AGLU154
APRO155
ALYS174

site_idAC2
Number of Residues2
Detailsbinding site for residue NA A 402
ChainResidue
AGLU154
AASP156

site_idAC3
Number of Residues11
Detailsbinding site for residue 6GT A 403
ChainResidue
ATYR143
AILE145
AARG148
ALYS171
AGLY194
AVAL213
AHOH530
AHOH578
AALA18
ATHR54
ATHR55

Functional Information from PROSITE/UniProt
site_idPS00665
Number of Residues18
DetailsDHDPS_1 Dihydrodipicolinate synthase signature 1. GLVvsGTTGESptttdgE
ChainResidueDetails
AGLY48-GLU65

site_idPS00666
Number of Residues31
DetailsDHDPS_2 Dihydrodipicolinate synthase signature 2. YDIPgrSavpIepdtiralashpn.IvGVKDA
ChainResidueDetails
ATYR143-ALA173

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_00418
ChainResidueDetails
ATYR143

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: Schiff-base intermediate with substrate => ECO:0000255|HAMAP-Rule:MF_00418, ECO:0000269|PubMed:21672512
ChainResidueDetails
ALYS171

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00418
ChainResidueDetails
ATHR55
AILE211

site_idSWS_FT_FI4
Number of Residues2
DetailsSITE: Part of a proton relay during catalysis => ECO:0000255|HAMAP-Rule:MF_00418
ChainResidueDetails
ATHR54
ATYR117

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PDB entries from 2024-07-17

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