5J4Y

The crystal structure of N-(4-(2-(thiazolo[5,4-c]pyridin-2-yl)phenoxy)phenyl)acetamide bound to JCV Helicase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0005524	molecular_function	ATP binding
A	0006260	biological_process	DNA replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 701

Chain	Residue
A	CYS303
A	CYS306
A	HIS314
A	HIS318

---

site_id	AC2
Number of Residues	6
Details	binding site for residue MES A 702

Chain	Residue
A	MET610
A	ILE581
A	TRP582
A	LYS601
A	ASP605
A	SER609

---

site_id	AC3
Number of Residues	6
Details	binding site for residue SO4 A 703

Chain	Residue
A	LYS282
A	CYS283
A	GLU284
A	ASP285
A	LEU288
A	HOH802

---

site_id	AC4
Number of Residues	9
Details	binding site for residue SO4 A 704

Chain	Residue
A	ASP430
A	SER431
A	GLY432
A	LYS433
A	THR434
A	THR435
A	ARG499
A	6JG705
A	HOH807

---

site_id	AC5
Number of Residues	14
Details	binding site for residue 6JG A 705

Chain	Residue
A	TRP394
A	LYS419
A	LYS420
A	ASP430
A	SER431
A	GLY432
A	THR435
A	PRO550
A	LYS551
A	LEU554
A	ARG555
A	LEU558
A	LEU565
A	SO4704

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	160
Details	Domain: {"description":"SF3 helicase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00551","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	92
Details	Zinc finger: {"description":"T-ag D1-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00671","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00671","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00551","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---