5J3R
Crystal structure of yeast monothiol glutaredoxin Grx6 in complex with a glutathione-coordinated [2Fe-2S] cluster
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000324 | cellular_component | fungal-type vacuole |
| A | 0004362 | molecular_function | glutathione-disulfide reductase (NADPH) activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005773 | cellular_component | vacuole |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005796 | cellular_component | Golgi lumen |
| A | 0005801 | cellular_component | cis-Golgi network |
| A | 0006879 | biological_process | intracellular iron ion homeostasis |
| A | 0015038 | molecular_function | glutathione disulfide oxidoreductase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016226 | biological_process | iron-sulfur cluster assembly |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051536 | molecular_function | iron-sulfur cluster binding |
| A | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
| A | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue FES A 301 |
| Chain | Residue |
| A | CYS136 |
| A | CYS136 |
| A | TYR138 |
| A | TYR138 |
| A | GSH302 |
| A | GSH302 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue GSH A 302 |
| Chain | Residue |
| A | TYR138 |
| A | GLN171 |
| A | THR182 |
| A | VAL183 |
| A | GLY195 |
| A | ASN196 |
| A | GLU197 |
| A | GLU198 |
| A | FES301 |
| A | FES301 |
| A | HOH401 |
| A | LYS133 |
| A | THR135 |
| A | SER137 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 103 |
| Details | Domain: {"description":"Glutaredoxin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00686","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
