5J23
Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase SMc04462 (SmGhrB) from Sinorhizobium meliloti in complex with 2'-phospho-ADP-ribose
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
| A | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051287 | molecular_function | NAD binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
| B | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051287 | molecular_function | NAD binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
| C | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0051287 | molecular_function | NAD binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0005829 | cellular_component | cytosol |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
| D | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 401 |
| Chain | Residue |
| A | VAL95 |
| A | THR285 |
| A | ALA288 |
| C | ARG141 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 402 |
| Chain | Residue |
| A | ASN13 |
| A | ARG286 |
| A | HOH633 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | binding site for residue A2R A 403 |
| Chain | Residue |
| A | GLY151 |
| A | ARG152 |
| A | ILE153 |
| A | THR172 |
| A | ARG173 |
| A | THR174 |
| A | ILE200 |
| A | PRO202 |
| A | SER206 |
| A | THR207 |
| A | VAL228 |
| A | GLY229 |
| A | ARG230 |
| A | HOH506 |
| A | HOH519 |
| A | HOH532 |
| A | HOH560 |
| A | HOH570 |
| A | PHE148 |
| A | LEU150 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue ACT B 401 |
| Chain | Residue |
| B | VAL95 |
| B | THR285 |
| B | HOH571 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 402 |
| Chain | Residue |
| B | ASN13 |
| B | ARG286 |
| B | HOH583 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 403 |
| Chain | Residue |
| B | HIS277 |
| B | A2R404 |
| site_id | AC7 |
| Number of Residues | 17 |
| Details | binding site for residue A2R B 404 |
| Chain | Residue |
| B | LEU150 |
| B | GLY151 |
| B | ARG152 |
| B | ILE153 |
| B | THR172 |
| B | ARG173 |
| B | THR174 |
| B | ILE200 |
| B | PRO202 |
| B | SER206 |
| B | THR207 |
| B | ARG230 |
| B | CL403 |
| B | HOH509 |
| B | HOH557 |
| B | HOH581 |
| B | HOH582 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ACT C 401 |
| Chain | Residue |
| A | ARG141 |
| C | VAL95 |
| C | THR285 |
| C | ALA288 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue CL C 402 |
| Chain | Residue |
| C | ASN13 |
| C | ARG286 |
| C | HOH625 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue CL C 403 |
| Chain | Residue |
| C | ARG230 |
| C | HIS277 |
| C | A2R404 |
| site_id | AD2 |
| Number of Residues | 18 |
| Details | binding site for residue A2R C 404 |
| Chain | Residue |
| C | LEU150 |
| C | GLY151 |
| C | ARG152 |
| C | ILE153 |
| C | THR172 |
| C | ARG173 |
| C | THR174 |
| C | ILE200 |
| C | PRO202 |
| C | SER206 |
| C | THR207 |
| C | ARG230 |
| C | CL403 |
| C | HOH505 |
| C | HOH523 |
| C | HOH527 |
| C | HOH538 |
| C | HOH577 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue CL D 401 |
| Chain | Residue |
| D | ASN13 |
| D | ARG286 |
| D | HOH638 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue CL D 402 |
| Chain | Residue |
| D | ARG230 |
| D | HIS277 |
| D | A2R403 |
| D | HOH551 |
| site_id | AD5 |
| Number of Residues | 26 |
| Details | binding site for residue A2R D 403 |
| Chain | Residue |
| D | PRO202 |
| D | SER206 |
| D | THR207 |
| D | VAL228 |
| D | GLY229 |
| D | ARG230 |
| D | CL402 |
| D | HOH506 |
| D | HOH507 |
| D | HOH517 |
| D | HOH539 |
| D | HOH547 |
| D | HOH564 |
| D | HOH569 |
| D | VAL72 |
| D | GLY73 |
| D | PHE148 |
| D | LEU150 |
| D | GLY151 |
| D | ARG152 |
| D | ILE153 |
| D | THR172 |
| D | ARG173 |
| D | THR174 |
| D | ILE200 |
| D | VAL201 |
