5IZK
The crystal structure of human eEFSec in complex with GDP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0001514 | biological_process | selenocysteine incorporation |
| A | 0003746 | molecular_function | translation elongation factor activity |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006412 | biological_process | translation |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0035368 | molecular_function | selenocysteine insertion sequence binding |
| A | 0043021 | molecular_function | ribonucleoprotein complex binding |
| A | 1990904 | cellular_component | ribonucleoprotein complex |
| B | 0000049 | molecular_function | tRNA binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0001514 | biological_process | selenocysteine incorporation |
| B | 0003746 | molecular_function | translation elongation factor activity |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006412 | biological_process | translation |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0035368 | molecular_function | selenocysteine insertion sequence binding |
| B | 0043021 | molecular_function | ribonucleoprotein complex binding |
| B | 1990904 | cellular_component | ribonucleoprotein complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue GDP A 1001 |
| Chain | Residue |
| A | ILE16 |
| A | PRO188 |
| A | GLY19 |
| A | LYS20 |
| A | THR21 |
| A | ALA22 |
| A | PRO94 |
| A | ASP149 |
| A | LEU150 |
| A | LYS187 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue GDP B 1001 |
| Chain | Residue |
| B | GLY19 |
| B | LYS20 |
| B | THR21 |
| B | ALA22 |
| B | PRO94 |
| B | ASN146 |
| B | LYS147 |
| B | ASP149 |
| B | ALA185 |
| B | ALA186 |
| B | LYS187 |
| B | HOH1102 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | Region: {"description":"G1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Region: {"description":"G3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Region: {"description":"G4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Region: {"description":"G5","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27708257","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27708257","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IZL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9JHW4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
