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5IZJ

Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1411

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0001669cellular_componentacrosomal vesicle
A0001707biological_processmesoderm formation
A0001843biological_processneural tube closure
A0002027biological_processregulation of heart rate
A0003091biological_processrenal water homeostasis
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004679molecular_functionAMP-activated protein kinase activity
A0004691molecular_functioncAMP-dependent protein kinase activity
A0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005930cellular_componentaxoneme
A0005952cellular_componentcAMP-dependent protein kinase complex
A0006397biological_processmRNA processing
A0006468biological_processprotein phosphorylation
A0006611biological_processprotein export from nucleus
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0010737biological_processprotein kinase A signaling
A0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A0016241biological_processregulation of macroautophagy
A0016607cellular_componentnuclear speck
A0018105biological_processpeptidyl-serine phosphorylation
A0019221biological_processcytokine-mediated signaling pathway
A0019901molecular_functionprotein kinase binding
A0019904molecular_functionprotein domain specific binding
A0030145molecular_functionmanganese ion binding
A0031410cellular_componentcytoplasmic vesicle
A0031514cellular_componentmotile cilium
A0031594cellular_componentneuromuscular junction
A0031625molecular_functionubiquitin protein ligase binding
A0032024biological_processpositive regulation of insulin secretion
A0032703biological_processnegative regulation of interleukin-2 production
A0034237molecular_functionprotein kinase A regulatory subunit binding
A0034380biological_processhigh-density lipoprotein particle assembly
A0034605biological_processcellular response to heat
A0034704cellular_componentcalcium channel complex
A0035694biological_processmitochondrial protein catabolic process
A0036126cellular_componentsperm flagellum
A0043197cellular_componentdendritic spine
A0044853cellular_componentplasma membrane raft
A0045667biological_processregulation of osteoblast differentiation
A0045722biological_processpositive regulation of gluconeogenesis
A0045879biological_processnegative regulation of smoothened signaling pathway
A0046827biological_processpositive regulation of protein export from nucleus
A0048240biological_processsperm capacitation
A0048471cellular_componentperinuclear region of cytoplasm
A0050804biological_processmodulation of chemical synaptic transmission
A0050850biological_processpositive regulation of calcium-mediated signaling
A0051726biological_processregulation of cell cycle
A0055117biological_processregulation of cardiac muscle contraction
A0061136biological_processregulation of proteasomal protein catabolic process
A0070062cellular_componentextracellular exosome
A0070417biological_processcellular response to cold
A0070613biological_processregulation of protein processing
A0071333biological_processcellular response to glucose stimulus
A0071374biological_processcellular response to parathyroid hormone stimulus
A0071377biological_processcellular response to glucagon stimulus
A0071872biological_processcellular response to epinephrine stimulus
A0086064biological_processcell communication by electrical coupling involved in cardiac conduction
A0097546cellular_componentciliary base
A0098978cellular_componentglutamatergic synapse
A0099103molecular_functionchannel activator activity
A0099170biological_processpostsynaptic modulation of chemical synaptic transmission
A0106310molecular_functionprotein serine kinase activity
A1903779biological_processregulation of cardiac conduction
A1904262biological_processnegative regulation of TORC1 signaling
A1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
A1990044biological_processprotein localization to lipid droplet
A2000810biological_processregulation of bicellular tight junction assembly
B0000287molecular_functionmagnesium ion binding
B0001669cellular_componentacrosomal vesicle
B0001707biological_processmesoderm formation
B0001843biological_processneural tube closure
B0002027biological_processregulation of heart rate
B0003091biological_processrenal water homeostasis
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004679molecular_functionAMP-activated protein kinase activity
B0004691molecular_functioncAMP-dependent protein kinase activity
B0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005930cellular_componentaxoneme
B0005952cellular_componentcAMP-dependent protein kinase complex
B0006397biological_processmRNA processing
B0006468biological_processprotein phosphorylation
B0006611biological_processprotein export from nucleus
B0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
B0010737biological_processprotein kinase A signaling
B0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B0016241biological_processregulation of macroautophagy
B0016607cellular_componentnuclear speck
B0018105biological_processpeptidyl-serine phosphorylation
B0019221biological_processcytokine-mediated signaling pathway
B0019901molecular_functionprotein kinase binding
B0019904molecular_functionprotein domain specific binding
B0030145molecular_functionmanganese ion binding
B0031410cellular_componentcytoplasmic vesicle
B0031514cellular_componentmotile cilium
B0031594cellular_componentneuromuscular junction
B0031625molecular_functionubiquitin protein ligase binding
B0032024biological_processpositive regulation of insulin secretion
B0032703biological_processnegative regulation of interleukin-2 production
B0034237molecular_functionprotein kinase A regulatory subunit binding
B0034380biological_processhigh-density lipoprotein particle assembly
B0034605biological_processcellular response to heat
B0034704cellular_componentcalcium channel complex
B0035694biological_processmitochondrial protein catabolic process
B0036126cellular_componentsperm flagellum
B0043197cellular_componentdendritic spine
B0044853cellular_componentplasma membrane raft
B0045667biological_processregulation of osteoblast differentiation
B0045722biological_processpositive regulation of gluconeogenesis
B0045879biological_processnegative regulation of smoothened signaling pathway
B0046827biological_processpositive regulation of protein export from nucleus
B0048240biological_processsperm capacitation
B0048471cellular_componentperinuclear region of cytoplasm
B0050804biological_processmodulation of chemical synaptic transmission
B0050850biological_processpositive regulation of calcium-mediated signaling
B0051726biological_processregulation of cell cycle
B0055117biological_processregulation of cardiac muscle contraction
B0061136biological_processregulation of proteasomal protein catabolic process
B0070062cellular_componentextracellular exosome
B0070417biological_processcellular response to cold
B0070613biological_processregulation of protein processing
B0071333biological_processcellular response to glucose stimulus
B0071374biological_processcellular response to parathyroid hormone stimulus
B0071377biological_processcellular response to glucagon stimulus
B0071872biological_processcellular response to epinephrine stimulus
B0086064biological_processcell communication by electrical coupling involved in cardiac conduction
B0097546cellular_componentciliary base
B0098978cellular_componentglutamatergic synapse
B0099103molecular_functionchannel activator activity
B0099170biological_processpostsynaptic modulation of chemical synaptic transmission
B0106310molecular_functionprotein serine kinase activity
B1903779biological_processregulation of cardiac conduction
B1904262biological_processnegative regulation of TORC1 signaling
B1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
B1990044biological_processprotein localization to lipid droplet
B2000810biological_processregulation of bicellular tight junction assembly
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue PO4 A 401
ChainResidue
ATYR235
APRO258
AHIS260
AHOH503
AHOH520
AHOH656

site_idAC2
Number of Residues8
Detailsbinding site for residue PO4 A 402
ChainResidue
AGLY282
AGLY287
AVAL288
AHOH562
AHOH665
AHIS158
ALYS217
ATRP221

site_idAC3
Number of Residues6
Detailsbinding site for residue PO4 A 403
ChainResidue
AARG194
ATRP196
ALYS213
AGLY214
AHOH510
AHOH636

site_idAC4
Number of Residues7
Detailsbinding site for residue PO4 A 404
ChainResidue
ALYS72
ATHR183
AASP184
AHOH568
AHOH612
AHOH662
G6J91

site_idAC5
Number of Residues8
Detailsbinding site for residue PO4 A 405
ChainResidue
APHE54
ALYS72
AHIS87
AGLU91
AGLY186
AHOH568
GZEU2
GDAR3

site_idAC6
Number of Residues4
Detailsbinding site for residue PO4 A 406
ChainResidue
APRO141
AARG144
ATHR299
AHOH673

site_idAC7
Number of Residues5
Detailsbinding site for residue PO4 A 407
ChainResidue
ALYS266
AARG270
AARG336
AHOH554
AHOH620

site_idAC8
Number of Residues3
Detailsbinding site for residue PO4 A 408
ChainResidue
AGLN77
ALYS342
AHOH641

site_idAC9
Number of Residues1
Detailsbinding site for residue PO4 A 409
ChainResidue
ALYS189

site_idAD1
Number of Residues4
Detailsbinding site for residue PO4 A 410
ChainResidue
APRO101
AARG308
AHOH515
AHOH678

site_idAD2
Number of Residues2
Detailsbinding site for residue PO4 A 411
ChainResidue
ALYS309
AHOH658

site_idAD3
Number of Residues2
Detailsbinding site for residue PO4 A 412
ChainResidue
AHIS142
AHOH657

site_idAD4
Number of Residues5
Detailsbinding site for residue PO4 A 413
ChainResidue
ASER139
AGLU140
APRO141
AHOH504
AHOH512

site_idAD5
Number of Residues6
Detailsbinding site for residue 6J9 A 414
ChainResidue
AVAL15
APHE18
ALEU152
AGLU155
ALYS292
ATYR306

site_idAD6
Number of Residues9
Detailsbinding site for residue PO4 B 401
ChainResidue
BHIS158
BLYS217
BTRP221
BGLY282
BGLY287
BVAL288
BHOH539
BHOH660
BHOH750

site_idAD7
Number of Residues6
Detailsbinding site for residue PO4 B 402
ChainResidue
ALYS249
AHOH617
BTYR235
BHOH505
BHOH566
BHOH654

site_idAD8
Number of Residues10
Detailsbinding site for residue PO4 B 403
ChainResidue
BLYS72
BTHR183
BASP184
BHOH534
BHOH596
BHOH659
BHOH748
F6J91
FZEU2
FDAR5

site_idAD9
Number of Residues4
Detailsbinding site for residue PO4 B 404
ChainResidue
BARG194
BTRP196
BGLY214
BHOH706

site_idAE1
Number of Residues2
Detailsbinding site for residue PO4 B 405
ChainResidue
BLYS189
BHOH666

site_idAE2
Number of Residues8
Detailsbinding site for residue PO4 B 406
ChainResidue
BLYS168
BASP184
BHOH617
BHOH623
BHOH730
FDAR3
FDAR5
BASP166

site_idAE3
Number of Residues2
Detailsbinding site for residue PO4 B 407
ChainResidue
BARG133
BARG134

site_idAE4
Number of Residues5
Detailsbinding site for residue PO4 B 408
ChainResidue
BPRO141
BARG144
BTHR299
BHOH675
BHOH756

site_idAE5
Number of Residues2
Detailsbinding site for residue PO4 B 409
ChainResidue
BHIS142
BHOH762

site_idAE6
Number of Residues6
Detailsbinding site for residue PO4 B 410
ChainResidue
BASP41
BARG45
BGLU332
BHOH681
BHOH725
BHOH731

site_idAE7
Number of Residues2
Detailsbinding site for residue PO4 B 411
ChainResidue
BGLY193
BARG194

site_idAE8
Number of Residues3
Detailsbinding site for residue PO4 B 412
ChainResidue
ALYS28
BTRP30
BARG190

site_idAE9
Number of Residues4
Detailsbinding site for residue 6J9 B 413
ChainResidue
BPHE18
BLEU152
BILE303
BTYR306

site_idAF1
Number of Residues12
Detailsbinding site for residue PO4 F 101
ChainResidue
BPHE54
BLYS72
BHIS87
BGLU91
BGLY186
BHOH511
BHOH534
FZEU2
FDAR3
FDAR5
FHOH203
FHOH206

site_idAF2
Number of Residues19
Detailsbinding site for residues 6J9 F 1 and ZEU F 2
ChainResidue
BGLY50
BGLY52
BSER53
BPHE54
BGLY55
BALA70
BLEU74
BGLU121
BTYR122
BVAL123
BLEU173
BTHR183
BPO4403
BHOH571
FDAR3
FDAR5
FPO4101
FHOH204
FHOH205

site_idAF3
Number of Residues18
Detailsbinding site for Di-peptide ZEU F 2 and DAR F 3
ChainResidue
BGLY50
BGLY52
BSER53
BPHE54
BGLY55
BLEU74
BASP184
BGLY186
BPHE187
BPO4403
BPO4406
F6J91
FDAR4
FDAR5
FPO4101
FHOH202
FHOH205
FHOH206

site_idAF4
Number of Residues11
Detailsbinding site for Di-peptide DAR F 3 and DAR F 4
ChainResidue
BSER53
BPHE54
BASP184
BGLY186
BPHE187
BPO4406
FZEU2
FDAR5
FPO4101
FHOH202
FHOH206

site_idAF5
Number of Residues10
Detailsbinding site for Di-peptide DAR F 4 and DAR F 5
ChainResidue
BSER53
BASP184
BPO4403
BPO4406
BHOH659
FZEU2
FDAR3
FNH26
FPO4101
FHOH201

site_idAF6
Number of Residues9
Detailsbinding site for Di-peptide DAR F 5 and NH2 F 6
ChainResidue
BASP184
BPO4403
BPO4406
BHOH659
FZEU2
FDAR3
FDAR4
FPO4101
FHOH201

site_idAF7
Number of Residues17
Detailsbinding site for residues 6J9 G 1 and ZEU G 2
ChainResidue
ALEU49
AGLY50
ATHR51
AGLY52
ASER53
APHE54
AGLY55
AALA70
AGLU121
AVAL123
ALEU173
ATHR183
APHE327
APO4404
APO4405
AHOH534
GDAR3

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGSFGRVMlVkhketgnh..........YAMK
ChainResidueDetails
ALEU49-LYS72

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LiYrDLKpeNLLI
ChainResidueDetails
ALEU162-ILE174

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
AASP166
BASP166

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING:
ChainResidueDetails
ALEU49
BLEU49

site_idSWS_FT_FI3
Number of Residues6
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
ALYS168
BLYS72
BGLU121
BLYS168
AGLU121
ALYS72

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Deamidated asparagine => ECO:0000250|UniProtKB:P05132
ChainResidueDetails
AASN2
BASN2

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine; by autocatalysis => ECO:0000250|UniProtKB:P05132
ChainResidueDetails
BSER10
ASER10

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976
ChainResidueDetails
BTHR48
ATHR48

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P05132
ChainResidueDetails
BSER139
ASER139

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:12372837
ChainResidueDetails
BTHR195
ATHR195

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:12372837, ECO:0000269|PubMed:16765046, ECO:0000269|PubMed:20137943, ECO:0000269|PubMed:20481595, ECO:0000269|PubMed:20732331, ECO:0000269|PubMed:21774789, ECO:0000269|Ref.43
ChainResidueDetails
BTPO197
ATPO197

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P05132
ChainResidueDetails
BTYR330
ATYR330

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:16765046, ECO:0000269|PubMed:20137943, ECO:0000269|PubMed:20481595, ECO:0000269|PubMed:20732331, ECO:0000269|PubMed:21774789, ECO:0000269|Ref.43, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASEP338
BSEP338

site_idSWS_FT_FI12
Number of Residues2
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:25807930
ChainResidueDetails
AGLY1
BGLY1

221051

PDB entries from 2024-06-12

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