5IZJ
Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1411
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0001669 | cellular_component | acrosomal vesicle |
| A | 0002027 | biological_process | regulation of heart rate |
| A | 0003091 | biological_process | renal water homeostasis |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0004691 | molecular_function | cAMP-dependent protein kinase activity |
| A | 0004712 | molecular_function | protein serine/threonine/tyrosine kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0005811 | cellular_component | lipid droplet |
| A | 0005813 | cellular_component | centrosome |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005930 | cellular_component | axoneme |
| A | 0005952 | cellular_component | cAMP-dependent protein kinase complex |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0006397 | biological_process | mRNA processing |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| A | 0007193 | biological_process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| A | 0010881 | biological_process | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| A | 0010898 | biological_process | positive regulation of triglyceride catabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016241 | biological_process | regulation of macroautophagy |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016607 | cellular_component | nuclear speck |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019221 | biological_process | cytokine-mediated signaling pathway |
| A | 0019870 | molecular_function | potassium channel inhibitor activity |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0019904 | molecular_function | protein domain specific binding |
| A | 0030007 | biological_process | intracellular potassium ion homeostasis |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0031514 | cellular_component | motile cilium |
| A | 0031594 | cellular_component | neuromuscular junction |
| A | 0032024 | biological_process | positive regulation of insulin secretion |
| A | 0032703 | biological_process | negative regulation of interleukin-2 production |
| A | 0034237 | molecular_function | protein kinase A regulatory subunit binding |
| A | 0034380 | biological_process | high-density lipoprotein particle assembly |
| A | 0034605 | biological_process | cellular response to heat |
| A | 0034704 | cellular_component | calcium channel complex |
| A | 0035694 | biological_process | mitochondrial protein catabolic process |
| A | 0036126 | cellular_component | sperm flagellum |
| A | 0044853 | cellular_component | plasma membrane raft |
| A | 0045542 | biological_process | positive regulation of cholesterol biosynthetic process |
| A | 0045667 | biological_process | regulation of osteoblast differentiation |
| A | 0045722 | biological_process | positive regulation of gluconeogenesis |
| A | 0045820 | biological_process | negative regulation of glycolytic process |
| A | 0048240 | biological_process | sperm capacitation |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0050766 | biological_process | positive regulation of phagocytosis |
| A | 0050850 | biological_process | positive regulation of calcium-mediated signaling |
| A | 0051726 | biological_process | regulation of cell cycle |
| A | 0055117 | biological_process | regulation of cardiac muscle contraction |
| A | 0061136 | biological_process | regulation of proteasomal protein catabolic process |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070507 | biological_process | regulation of microtubule cytoskeleton organization |
| A | 0071333 | biological_process | cellular response to glucose stimulus |
| A | 0071377 | biological_process | cellular response to glucagon stimulus |
| A | 0071872 | biological_process | cellular response to epinephrine stimulus |
| A | 0086064 | biological_process | cell communication by electrical coupling involved in cardiac conduction |
| A | 0097546 | cellular_component | ciliary base |
| A | 0097700 | biological_process | vascular endothelial cell response to laminar fluid shear stress |
| A | 0098794 | cellular_component | postsynapse |
| A | 0098978 | cellular_component | glutamatergic synapse |
| A | 0099103 | molecular_function | channel activator activity |
| A | 0099170 | biological_process | postsynaptic modulation of chemical synaptic transmission |
| A | 0106310 | molecular_function | protein serine kinase activity |
| A | 0120186 | biological_process | negative regulation of protein localization to chromatin |
| A | 0140198 | molecular_function | histone H1-4S35 kinase activity |
| A | 1903779 | biological_process | regulation of cardiac conduction |
| A | 1904262 | biological_process | negative regulation of TORC1 signaling |
| A | 1904539 | biological_process | negative regulation of glycolytic process through fructose-6-phosphate |
| A | 2000810 | biological_process | regulation of bicellular tight junction assembly |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0001669 | cellular_component | acrosomal vesicle |
| B | 0002027 | biological_process | regulation of heart rate |
| B | 0003091 | biological_process | renal water homeostasis |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0004691 | molecular_function | cAMP-dependent protein kinase activity |
| B | 0004712 | molecular_function | protein serine/threonine/tyrosine kinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0005811 | cellular_component | lipid droplet |
| B | 0005813 | cellular_component | centrosome |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005930 | cellular_component | axoneme |
| B | 0005952 | cellular_component | cAMP-dependent protein kinase complex |
| B | 0006338 | biological_process | chromatin remodeling |
| B | 0006397 | biological_process | mRNA processing |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| B | 0007193 | biological_process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| B | 0010881 | biological_process | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| B | 0010898 | biological_process | positive regulation of triglyceride catabolic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016241 | biological_process | regulation of macroautophagy |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016607 | cellular_component | nuclear speck |
| B | 0016740 | molecular_function | transferase activity |
| B | 0019221 | biological_process | cytokine-mediated signaling pathway |
| B | 0019870 | molecular_function | potassium channel inhibitor activity |
| B | 0019901 | molecular_function | protein kinase binding |
| B | 0019904 | molecular_function | protein domain specific binding |
| B | 0030007 | biological_process | intracellular potassium ion homeostasis |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0031410 | cellular_component | cytoplasmic vesicle |
| B | 0031514 | cellular_component | motile cilium |
| B | 0031594 | cellular_component | neuromuscular junction |
| B | 0032024 | biological_process | positive regulation of insulin secretion |
| B | 0032703 | biological_process | negative regulation of interleukin-2 production |
| B | 0034237 | molecular_function | protein kinase A regulatory subunit binding |
| B | 0034380 | biological_process | high-density lipoprotein particle assembly |
| B | 0034605 | biological_process | cellular response to heat |
| B | 0034704 | cellular_component | calcium channel complex |
| B | 0035694 | biological_process | mitochondrial protein catabolic process |
| B | 0036126 | cellular_component | sperm flagellum |
| B | 0044853 | cellular_component | plasma membrane raft |
| B | 0045542 | biological_process | positive regulation of cholesterol biosynthetic process |
| B | 0045667 | biological_process | regulation of osteoblast differentiation |
| B | 0045722 | biological_process | positive regulation of gluconeogenesis |
| B | 0045820 | biological_process | negative regulation of glycolytic process |
| B | 0048240 | biological_process | sperm capacitation |
| B | 0048471 | cellular_component | perinuclear region of cytoplasm |
| B | 0050766 | biological_process | positive regulation of phagocytosis |
| B | 0050850 | biological_process | positive regulation of calcium-mediated signaling |
| B | 0051726 | biological_process | regulation of cell cycle |
| B | 0055117 | biological_process | regulation of cardiac muscle contraction |
| B | 0061136 | biological_process | regulation of proteasomal protein catabolic process |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070507 | biological_process | regulation of microtubule cytoskeleton organization |
| B | 0071333 | biological_process | cellular response to glucose stimulus |
| B | 0071377 | biological_process | cellular response to glucagon stimulus |
| B | 0071872 | biological_process | cellular response to epinephrine stimulus |
| B | 0086064 | biological_process | cell communication by electrical coupling involved in cardiac conduction |
| B | 0097546 | cellular_component | ciliary base |
| B | 0097700 | biological_process | vascular endothelial cell response to laminar fluid shear stress |
| B | 0098794 | cellular_component | postsynapse |
| B | 0098978 | cellular_component | glutamatergic synapse |
| B | 0099103 | molecular_function | channel activator activity |
| B | 0099170 | biological_process | postsynaptic modulation of chemical synaptic transmission |
| B | 0106310 | molecular_function | protein serine kinase activity |
| B | 0120186 | biological_process | negative regulation of protein localization to chromatin |
| B | 0140198 | molecular_function | histone H1-4S35 kinase activity |
| B | 1903779 | biological_process | regulation of cardiac conduction |
| B | 1904262 | biological_process | negative regulation of TORC1 signaling |
| B | 1904539 | biological_process | negative regulation of glycolytic process through fructose-6-phosphate |
| B | 2000810 | biological_process | regulation of bicellular tight junction assembly |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 A 401 |
| Chain | Residue |
| A | TYR235 |
| A | PRO258 |
| A | HIS260 |
| A | HOH503 |
| A | HOH520 |
| A | HOH656 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 A 402 |
| Chain | Residue |
| A | GLY282 |
| A | GLY287 |
| A | VAL288 |
| A | HOH562 |
| A | HOH665 |
| A | HIS158 |
| A | LYS217 |
| A | TRP221 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 A 403 |
| Chain | Residue |
| A | ARG194 |
| A | TRP196 |
| A | LYS213 |
| A | GLY214 |
| A | HOH510 |
| A | HOH636 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 A 404 |
| Chain | Residue |
| A | LYS72 |
| A | THR183 |
| A | ASP184 |
| A | HOH568 |
| A | HOH612 |
| A | HOH662 |
| G | 6J91 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 A 405 |
| Chain | Residue |
| A | PHE54 |
| A | LYS72 |
| A | HIS87 |
| A | GLU91 |
| A | GLY186 |
| A | HOH568 |
| G | ZEU2 |
| G | DAR3 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 A 406 |
| Chain | Residue |
| A | PRO141 |
| A | ARG144 |
| A | THR299 |
| A | HOH673 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 A 407 |
| Chain | Residue |
| A | LYS266 |
| A | ARG270 |
| A | ARG336 |
| A | HOH554 |
| A | HOH620 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 A 408 |
| Chain | Residue |
| A | GLN77 |
| A | LYS342 |
| A | HOH641 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue PO4 A 409 |
| Chain | Residue |
| A | LYS189 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 A 410 |
| Chain | Residue |
| A | PRO101 |
| A | ARG308 |
| A | HOH515 |
| A | HOH678 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 A 411 |
| Chain | Residue |
| A | LYS309 |
| A | HOH658 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 A 412 |
| Chain | Residue |
| A | HIS142 |
| A | HOH657 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 A 413 |
| Chain | Residue |
| A | SER139 |
| A | GLU140 |
| A | PRO141 |
| A | HOH504 |
| A | HOH512 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue 6J9 A 414 |
| Chain | Residue |
| A | VAL15 |
| A | PHE18 |
| A | LEU152 |
| A | GLU155 |
| A | LYS292 |
| A | TYR306 |
| site_id | AD6 |
| Number of Residues | 9 |
| Details | binding site for residue PO4 B 401 |
| Chain | Residue |
| B | HIS158 |
| B | LYS217 |
| B | TRP221 |
| B | GLY282 |
| B | GLY287 |
| B | VAL288 |
| B | HOH539 |
| B | HOH660 |
| B | HOH750 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 B 402 |
| Chain | Residue |
| A | LYS249 |
| A | HOH617 |
| B | TYR235 |
| B | HOH505 |
| B | HOH566 |
| B | HOH654 |
| site_id | AD8 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 B 403 |
| Chain | Residue |
| B | LYS72 |
| B | THR183 |
| B | ASP184 |
| B | HOH534 |
| B | HOH596 |
| B | HOH659 |
| B | HOH748 |
| F | 6J91 |
| F | ZEU2 |
| F | DAR5 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 B 404 |
| Chain | Residue |
| B | ARG194 |
| B | TRP196 |
| B | GLY214 |
| B | HOH706 |
| site_id | AE1 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 B 405 |
| Chain | Residue |
| B | LYS189 |
| B | HOH666 |
| site_id | AE2 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 B 406 |
| Chain | Residue |
| B | LYS168 |
| B | ASP184 |
| B | HOH617 |
| B | HOH623 |
| B | HOH730 |
| F | DAR3 |
| F | DAR5 |
| B | ASP166 |
| site_id | AE3 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 B 407 |
| Chain | Residue |
| B | ARG133 |
| B | ARG134 |
| site_id | AE4 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 B 408 |
| Chain | Residue |
| B | PRO141 |
| B | ARG144 |
| B | THR299 |
| B | HOH675 |
| B | HOH756 |
| site_id | AE5 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 B 409 |
| Chain | Residue |
| B | HIS142 |
| B | HOH762 |
| site_id | AE6 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 B 410 |
| Chain | Residue |
| B | ASP41 |
| B | ARG45 |
| B | GLU332 |
| B | HOH681 |
| B | HOH725 |
| B | HOH731 |
| site_id | AE7 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 B 411 |
| Chain | Residue |
| B | GLY193 |
| B | ARG194 |
| site_id | AE8 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 B 412 |
| Chain | Residue |
| A | LYS28 |
| B | TRP30 |
| B | ARG190 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue 6J9 B 413 |
| Chain | Residue |
| B | PHE18 |
| B | LEU152 |
| B | ILE303 |
| B | TYR306 |
| site_id | AF1 |
| Number of Residues | 12 |
| Details | binding site for residue PO4 F 101 |
| Chain | Residue |
| B | PHE54 |
| B | LYS72 |
| B | HIS87 |
| B | GLU91 |
| B | GLY186 |
| B | HOH511 |
| B | HOH534 |
| F | ZEU2 |
| F | DAR3 |
| F | DAR5 |
| F | HOH203 |
| F | HOH206 |
| site_id | AF2 |
| Number of Residues | 19 |
| Details | binding site for residues 6J9 F 1 and ZEU F 2 |
| Chain | Residue |
| B | GLY50 |
| B | GLY52 |
| B | SER53 |
| B | PHE54 |
| B | GLY55 |
| B | ALA70 |
| B | LEU74 |
| B | GLU121 |
| B | TYR122 |
| B | VAL123 |
| B | LEU173 |
| B | THR183 |
| B | PO4403 |
| B | HOH571 |
| F | DAR3 |
| F | DAR5 |
| F | PO4101 |
| F | HOH204 |
| F | HOH205 |
| site_id | AF3 |
| Number of Residues | 18 |
| Details | binding site for Di-peptide ZEU F 2 and DAR F 3 |
| Chain | Residue |
| B | GLY50 |
| B | GLY52 |
| B | SER53 |
| B | PHE54 |
| B | GLY55 |
| B | LEU74 |
| B | ASP184 |
| B | GLY186 |
| B | PHE187 |
| B | PO4403 |
| B | PO4406 |
| F | 6J91 |
| F | DAR4 |
| F | DAR5 |
| F | PO4101 |
| F | HOH202 |
| F | HOH205 |
| F | HOH206 |
| site_id | AF4 |
| Number of Residues | 11 |
| Details | binding site for Di-peptide DAR F 3 and DAR F 4 |
| Chain | Residue |
| B | SER53 |
| B | PHE54 |
| B | ASP184 |
| B | GLY186 |
| B | PHE187 |
| B | PO4406 |
| F | ZEU2 |
| F | DAR5 |
| F | PO4101 |
| F | HOH202 |
| F | HOH206 |
| site_id | AF5 |
| Number of Residues | 10 |
| Details | binding site for Di-peptide DAR F 4 and DAR F 5 |
| Chain | Residue |
| B | SER53 |
| B | ASP184 |
| B | PO4403 |
| B | PO4406 |
| B | HOH659 |
| F | ZEU2 |
| F | DAR3 |
| F | NH26 |
| F | PO4101 |
| F | HOH201 |
| site_id | AF6 |
| Number of Residues | 9 |
| Details | binding site for Di-peptide DAR F 5 and NH2 F 6 |
| Chain | Residue |
| B | ASP184 |
| B | PO4403 |
| B | PO4406 |
| B | HOH659 |
| F | ZEU2 |
| F | DAR3 |
| F | DAR4 |
| F | PO4101 |
| F | HOH201 |
| site_id | AF7 |
| Number of Residues | 17 |
| Details | binding site for residues 6J9 G 1 and ZEU G 2 |
| Chain | Residue |
| A | LEU49 |
| A | GLY50 |
| A | THR51 |
| A | GLY52 |
| A | SER53 |
| A | PHE54 |
| A | GLY55 |
| A | ALA70 |
| A | GLU121 |
| A | VAL123 |
| A | LEU173 |
| A | THR183 |
| A | PHE327 |
| A | PO4404 |
| A | PO4405 |
| A | HOH534 |
| G | DAR3 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGSFGRVMlVkhketgnh..........YAMK |
| Chain | Residue | Details |
| A | LEU49-LYS72 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LiYrDLKpeNLLI |
| Chain | Residue | Details |
| A | LEU162-ILE174 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P05132","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"12372837","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by PDPK1","evidences":[{"source":"PubMed","id":"12372837","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16765046","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20137943","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20481595","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20732331","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21774789","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2010","submissionDatabase":"PDB data bank","title":"Experimental active site mapping as a starting point to fragment-based lead discovery.","authors":["Behnen J.","Koester H.","Ritschel T.","Neudert G.","Heine A.","Klebe G."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P05132","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16765046","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20137943","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20481595","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20732331","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21774789","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2010","submissionDatabase":"PDB data bank","title":"Experimental active site mapping as a starting point to fragment-based lead discovery.","authors":["Behnen J.","Koester H.","Ritschel T.","Neudert G.","Heine A.","Klebe G."]}},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
