5IZD

Wild-type glyceraldehyde dehydrogenase from Thermoplasma acidophilum in complex with NADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004777	molecular_function	succinate-semialdehyde dehydrogenase (NAD+) activity
A	0005829	cellular_component	cytosol
A	0006096	biological_process	glycolytic process
A	0009255	biological_process	Entner-Doudoroff pathway through 6-phosphogluconate
A	0009450	biological_process	GABA catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0042803	molecular_function	protein homodimerization activity
A	0043796	molecular_function	glyceraldehyde dehydrogenase (NADP+) activity
A	0051289	biological_process	protein homotetramerization
B	0004777	molecular_function	succinate-semialdehyde dehydrogenase (NAD+) activity
B	0005829	cellular_component	cytosol
B	0006096	biological_process	glycolytic process
B	0009255	biological_process	Entner-Doudoroff pathway through 6-phosphogluconate
B	0009450	biological_process	GABA catabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0042803	molecular_function	protein homodimerization activity
B	0043796	molecular_function	glyceraldehyde dehydrogenase (NADP+) activity
B	0051289	biological_process	protein homotetramerization
C	0004777	molecular_function	succinate-semialdehyde dehydrogenase (NAD+) activity
C	0005829	cellular_component	cytosol
C	0006096	biological_process	glycolytic process
C	0009255	biological_process	Entner-Doudoroff pathway through 6-phosphogluconate
C	0009450	biological_process	GABA catabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0042803	molecular_function	protein homodimerization activity
C	0043796	molecular_function	glyceraldehyde dehydrogenase (NADP+) activity
C	0051289	biological_process	protein homotetramerization
D	0004777	molecular_function	succinate-semialdehyde dehydrogenase (NAD+) activity
D	0005829	cellular_component	cytosol
D	0006096	biological_process	glycolytic process
D	0009255	biological_process	Entner-Doudoroff pathway through 6-phosphogluconate
D	0009450	biological_process	GABA catabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0042803	molecular_function	protein homodimerization activity
D	0043796	molecular_function	glyceraldehyde dehydrogenase (NADP+) activity
D	0051289	biological_process	protein homotetramerization
E	0004777	molecular_function	succinate-semialdehyde dehydrogenase (NAD+) activity
E	0005829	cellular_component	cytosol
E	0006096	biological_process	glycolytic process
E	0009255	biological_process	Entner-Doudoroff pathway through 6-phosphogluconate
E	0009450	biological_process	GABA catabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0042803	molecular_function	protein homodimerization activity
E	0043796	molecular_function	glyceraldehyde dehydrogenase (NADP+) activity
E	0051289	biological_process	protein homotetramerization
F	0004777	molecular_function	succinate-semialdehyde dehydrogenase (NAD+) activity
F	0005829	cellular_component	cytosol
F	0006096	biological_process	glycolytic process
F	0009255	biological_process	Entner-Doudoroff pathway through 6-phosphogluconate
F	0009450	biological_process	GABA catabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0042803	molecular_function	protein homodimerization activity
F	0043796	molecular_function	glyceraldehyde dehydrogenase (NADP+) activity
F	0051289	biological_process	protein homotetramerization
G	0004777	molecular_function	succinate-semialdehyde dehydrogenase (NAD+) activity
G	0005829	cellular_component	cytosol
G	0006096	biological_process	glycolytic process
G	0009255	biological_process	Entner-Doudoroff pathway through 6-phosphogluconate
G	0009450	biological_process	GABA catabolic process
G	0016491	molecular_function	oxidoreductase activity
G	0042803	molecular_function	protein homodimerization activity
G	0043796	molecular_function	glyceraldehyde dehydrogenase (NADP+) activity
G	0051289	biological_process	protein homotetramerization
H	0004777	molecular_function	succinate-semialdehyde dehydrogenase (NAD+) activity
H	0005829	cellular_component	cytosol
H	0006096	biological_process	glycolytic process
H	0009255	biological_process	Entner-Doudoroff pathway through 6-phosphogluconate
H	0009450	biological_process	GABA catabolic process
H	0016491	molecular_function	oxidoreductase activity
H	0042803	molecular_function	protein homodimerization activity
H	0043796	molecular_function	glyceraldehyde dehydrogenase (NADP+) activity
H	0051289	biological_process	protein homotetramerization

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue NAP A 601

Chain	Residue
A	LEU145
A	GLY205
A	GLY209
A	ASP210
A	THR224
A	GLY225
A	SER226
A	THR229
A	HOH714
A	HOH737
A	HOH793
A	THR146
A	TRP148
A	LYS172
A	PRO173
A	SER174
A	SER175
A	GLY203
A	ARG204

---

site_id	AC2
Number of Residues	18
Details	binding site for residue NAP B 601

Chain	Residue
B	LEU145
B	THR146
B	PRO147
B	TRP148
B	LYS172
B	PRO173
B	SER174
B	SER175
B	GLY203
B	GLY205
B	GLY209
B	ASP210
B	MET223
B	THR224
B	GLY225
B	SER226
B	THR229
B	HOH711

---

site_id	AC3
Number of Residues	19
Details	binding site for residue NAP C 601

Chain	Residue
C	LEU145
C	THR146
C	TRP148
C	LYS172
C	PRO173
C	SER174
C	SER175
C	GLY203
C	ARG204
C	GLY205
C	GLY209
C	ASP210
C	SER226
C	THR229
C	ARG232
C	HOH724
C	HOH730
C	HOH743
C	HOH756

---

site_id	AC4
Number of Residues	17
Details	binding site for residue NAP D 601

Chain	Residue
D	LEU145
D	THR146
D	TRP148
D	LYS172
D	PRO173
D	SER174
D	SER175
D	GLY203
D	GLY205
D	GLY209
D	ASP210
D	MET223
D	THR224
D	GLY225
D	SER226
D	THR229
D	ARG232

---

site_id	AC5
Number of Residues	16
Details	binding site for residue NAP G 601

Chain	Residue
G	LEU145
G	THR146
G	TRP148
G	LYS172
G	PRO173
G	SER174
G	SER175
G	GLY203
G	GLY205
G	GLY209
G	ASP210
G	MET223
G	THR224
G	GLY225
G	SER226
G	THR229

---

site_id	AC6
Number of Residues	18
Details	binding site for residue NAP H 601

Chain	Residue
H	ASP210
H	THR224
H	GLY225
H	SER226
H	THR229
H	ARG232
H	HOH713
H	HOH766
H	LEU145
H	THR146
H	TRP148
H	LYS172
H	PRO173
H	SER174
H	SER175
H	GLY203
H	GLY205
H	GLY209

---

Functional Information from PROSITE/UniProt

site_id	PS00070
Number of Residues	12
Details	ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. YwNAGQSCIAAE

Chain	Residue	Details
A	TYR274-GLU285

---

site_id	PS00687
Number of Residues	8
Details	ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGKAP

Chain	Residue	Details
A	LEU246-PRO253

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	176
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10007","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P28037","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P28037","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"O57693","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	16
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q59931","evidenceCode":"ECO:0000250"},{"source":"UniProtKB","id":"Q84DC3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q84DC3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	184
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q59931","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P28037","evidenceCode":"ECO:0000250"},{"source":"UniProtKB","id":"Q59931","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	8
Details	Site: {"description":"Transition state stabilizer","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---