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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5IZD

Wild-type glyceraldehyde dehydrogenase from Thermoplasma acidophilum in complex with NADP

Functional Information from GO Data
ChainGOidnamespacecontents
A0004777molecular_functionsuccinate-semialdehyde dehydrogenase (NAD+) activity
A0005829cellular_componentcytosol
A0006096biological_processglycolytic process
A0009255biological_processEntner-Doudoroff pathway through 6-phosphogluconate
A0009450biological_processgamma-aminobutyric acid catabolic process
A0016491molecular_functionoxidoreductase activity
A0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A0042803molecular_functionprotein homodimerization activity
A0043796molecular_functionglyceraldehyde dehydrogenase (NADP+) activity
A0051289biological_processprotein homotetramerization
B0004777molecular_functionsuccinate-semialdehyde dehydrogenase (NAD+) activity
B0005829cellular_componentcytosol
B0006096biological_processglycolytic process
B0009255biological_processEntner-Doudoroff pathway through 6-phosphogluconate
B0009450biological_processgamma-aminobutyric acid catabolic process
B0016491molecular_functionoxidoreductase activity
B0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B0042803molecular_functionprotein homodimerization activity
B0043796molecular_functionglyceraldehyde dehydrogenase (NADP+) activity
B0051289biological_processprotein homotetramerization
C0004777molecular_functionsuccinate-semialdehyde dehydrogenase (NAD+) activity
C0005829cellular_componentcytosol
C0006096biological_processglycolytic process
C0009255biological_processEntner-Doudoroff pathway through 6-phosphogluconate
C0009450biological_processgamma-aminobutyric acid catabolic process
C0016491molecular_functionoxidoreductase activity
C0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C0042803molecular_functionprotein homodimerization activity
C0043796molecular_functionglyceraldehyde dehydrogenase (NADP+) activity
C0051289biological_processprotein homotetramerization
D0004777molecular_functionsuccinate-semialdehyde dehydrogenase (NAD+) activity
D0005829cellular_componentcytosol
D0006096biological_processglycolytic process
D0009255biological_processEntner-Doudoroff pathway through 6-phosphogluconate
D0009450biological_processgamma-aminobutyric acid catabolic process
D0016491molecular_functionoxidoreductase activity
D0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D0042803molecular_functionprotein homodimerization activity
D0043796molecular_functionglyceraldehyde dehydrogenase (NADP+) activity
D0051289biological_processprotein homotetramerization
E0004777molecular_functionsuccinate-semialdehyde dehydrogenase (NAD+) activity
E0005829cellular_componentcytosol
E0006096biological_processglycolytic process
E0009255biological_processEntner-Doudoroff pathway through 6-phosphogluconate
E0009450biological_processgamma-aminobutyric acid catabolic process
E0016491molecular_functionoxidoreductase activity
E0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
E0042803molecular_functionprotein homodimerization activity
E0043796molecular_functionglyceraldehyde dehydrogenase (NADP+) activity
E0051289biological_processprotein homotetramerization
F0004777molecular_functionsuccinate-semialdehyde dehydrogenase (NAD+) activity
F0005829cellular_componentcytosol
F0006096biological_processglycolytic process
F0009255biological_processEntner-Doudoroff pathway through 6-phosphogluconate
F0009450biological_processgamma-aminobutyric acid catabolic process
F0016491molecular_functionoxidoreductase activity
F0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
F0042803molecular_functionprotein homodimerization activity
F0043796molecular_functionglyceraldehyde dehydrogenase (NADP+) activity
F0051289biological_processprotein homotetramerization
G0004777molecular_functionsuccinate-semialdehyde dehydrogenase (NAD+) activity
G0005829cellular_componentcytosol
G0006096biological_processglycolytic process
G0009255biological_processEntner-Doudoroff pathway through 6-phosphogluconate
G0009450biological_processgamma-aminobutyric acid catabolic process
G0016491molecular_functionoxidoreductase activity
G0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
G0042803molecular_functionprotein homodimerization activity
G0043796molecular_functionglyceraldehyde dehydrogenase (NADP+) activity
G0051289biological_processprotein homotetramerization
H0004777molecular_functionsuccinate-semialdehyde dehydrogenase (NAD+) activity
H0005829cellular_componentcytosol
H0006096biological_processglycolytic process
H0009255biological_processEntner-Doudoroff pathway through 6-phosphogluconate
H0009450biological_processgamma-aminobutyric acid catabolic process
H0016491molecular_functionoxidoreductase activity
H0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
H0042803molecular_functionprotein homodimerization activity
H0043796molecular_functionglyceraldehyde dehydrogenase (NADP+) activity
H0051289biological_processprotein homotetramerization
Functional Information from PDB Data
site_idAC1
Number of Residues19
Detailsbinding site for residue NAP A 601
ChainResidue
ALEU145
AGLY205
AGLY209
AASP210
ATHR224
AGLY225
ASER226
ATHR229
AHOH714
AHOH737
AHOH793
ATHR146
ATRP148
ALYS172
APRO173
ASER174
ASER175
AGLY203
AARG204
site_idAC2
Number of Residues18
Detailsbinding site for residue NAP B 601
ChainResidue
BLEU145
BTHR146
BPRO147
BTRP148
BLYS172
BPRO173
BSER174
BSER175
BGLY203
BGLY205
BGLY209
BASP210
BMET223
BTHR224
BGLY225
BSER226
BTHR229
BHOH711
site_idAC3
Number of Residues19
Detailsbinding site for residue NAP C 601
ChainResidue
CLEU145
CTHR146
CTRP148
CLYS172
CPRO173
CSER174
CSER175
CGLY203
CARG204
CGLY205
CGLY209
CASP210
CSER226
CTHR229
CARG232
CHOH724
CHOH730
CHOH743
CHOH756
site_idAC4
Number of Residues17
Detailsbinding site for residue NAP D 601
ChainResidue
DLEU145
DTHR146
DTRP148
DLYS172
DPRO173
DSER174
DSER175
DGLY203
DGLY205
DGLY209
DASP210
DMET223
DTHR224
DGLY225
DSER226
DTHR229
DARG232
site_idAC5
Number of Residues16
Detailsbinding site for residue NAP G 601
ChainResidue
GLEU145
GTHR146
GTRP148
GLYS172
GPRO173
GSER174
GSER175
GGLY203
GGLY205
GGLY209
GASP210
GMET223
GTHR224
GGLY225
GSER226
GTHR229
site_idAC6
Number of Residues18
Detailsbinding site for residue NAP H 601
ChainResidue
HASP210
HTHR224
HGLY225
HSER226
HTHR229
HARG232
HHOH713
HHOH766
HLEU145
HTHR146
HTRP148
HLYS172
HPRO173
HSER174
HSER175
HGLY203
HGLY205
HGLY209
Functional Information from PROSITE/UniProt
site_idPS00070
Number of Residues12
DetailsALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. YwNAGQSCIAAE
ChainResidueDetails
ATYR274-GLU285
site_idPS00687
Number of Residues8
DetailsALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGKAP
ChainResidueDetails
ALEU246-PRO253
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues176
DetailsCoiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues8
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10007","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues8
DetailsActive site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P28037","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues24
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P28037","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"O57693","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues16
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues32
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q59931","evidenceCode":"ECO:0000250"},{"source":"UniProtKB","id":"Q84DC3","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues48
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q84DC3","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues184
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q59931","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P28037","evidenceCode":"ECO:0000250"},{"source":"UniProtKB","id":"Q59931","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues8
DetailsSite: {"description":"Transition state stabilizer","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

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PDB entries from 2025-12-17

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