5IYS

Crystal structure of a dehydrosqualene synthase in complex with ligand

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004311	molecular_function	geranylgeranyl diphosphate synthase activity
A	0009058	biological_process	biosynthetic process
A	0016114	biological_process	terpenoid biosynthetic process
A	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
A	0046872	molecular_function	metal ion binding
A	0051996	molecular_function	squalene synthase [NAD(P)H] activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue SO4 A 501

Chain	Residue
A	ARG114
A	SER271
A	HIS272
A	HOH677

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site_id	AC2
Number of Residues	6
Details	binding site for residue SO4 A 502

Chain	Residue
A	HOH636
A	LYS115
A	SER271
A	TYR273
A	HOH621
A	HOH629

---

site_id	AC3
Number of Residues	6
Details	binding site for residue MG A 503

Chain	Residue
A	ASN169
A	ASP173
A	FPS507
A	HOH607
A	HOH614
A	HOH642

---

site_id	AC4
Number of Residues	7
Details	binding site for residue MG A 504

Chain	Residue
A	ASP56
A	ASP60
A	MG505
A	FPS507
A	HOH627
A	HOH662
A	HOH734

---

site_id	AC5
Number of Residues	6
Details	binding site for residue MG A 505

Chain	Residue
A	ASP56
A	ASP60
A	MG504
A	FPS507
A	HOH619
A	HOH653

---

site_id	AC6
Number of Residues	12
Details	binding site for residue FPS A 506

Chain	Residue
A	SER27
A	PHE30
A	TYR49
A	ARG53
A	VAL139
A	GLY140
A	LEU161
A	ASN169
A	ARG172
A	LEU242
A	TYR249
A	FPS507

---

site_id	AC7
Number of Residues	21
Details	binding site for residue FPS A 507

Chain	Residue
A	PHE34
A	TYR49
A	CYS52
A	ARG53
A	ASP56
A	ASP60
A	MET109
A	GLN113
A	VAL135
A	GLN166
A	ASN169
A	LYS267
A	MG503
A	MG504
A	MG505
A	FPS506
A	HOH603
A	HOH607
A	HOH614
A	HOH653
A	HOH662

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