5IYC

Human core-PIC in the initial transcribing state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0000974	cellular_component	Prp19 complex
A	0001055	molecular_function	RNA polymerase II activity
A	0001172	biological_process	RNA-templated transcription
A	0003677	molecular_function	DNA binding
A	0003723	molecular_function	RNA binding
A	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
A	0003968	molecular_function	RNA-dependent RNA polymerase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005665	cellular_component	RNA polymerase II, core complex
A	0005694	cellular_component	chromosome
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0006351	biological_process	DNA-templated transcription
A	0006353	biological_process	DNA-templated transcription termination
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006366	biological_process	transcription by RNA polymerase II
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
A	0019900	molecular_function	kinase binding
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0031981	cellular_component	nuclear lumen
A	0032991	cellular_component	protein-containing complex
A	0033120	biological_process	positive regulation of RNA splicing
A	0034062	molecular_function	5'-3' RNA polymerase activity
A	0046872	molecular_function	metal ion binding
A	0050436	molecular_function	microfibril binding
A	1990841	molecular_function	promoter-specific chromatin binding
B	0000428	cellular_component	DNA-directed RNA polymerase complex
B	0000781	cellular_component	chromosome, telomeric region
B	0001055	molecular_function	RNA polymerase II activity
B	0001172	biological_process	RNA-templated transcription
B	0003677	molecular_function	DNA binding
B	0003682	molecular_function	chromatin binding
B	0003723	molecular_function	RNA binding
B	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
B	0003968	molecular_function	RNA-dependent RNA polymerase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005665	cellular_component	RNA polymerase II, core complex
B	0006351	biological_process	DNA-templated transcription
B	0006366	biological_process	transcription by RNA polymerase II
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0032549	molecular_function	ribonucleoside binding
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0046872	molecular_function	metal ion binding
C	0000428	cellular_component	DNA-directed RNA polymerase complex
C	0001055	molecular_function	RNA polymerase II activity
C	0003677	molecular_function	DNA binding
C	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005665	cellular_component	RNA polymerase II, core complex
C	0005829	cellular_component	cytosol
C	0006351	biological_process	DNA-templated transcription
C	0006366	biological_process	transcription by RNA polymerase II
C	0046983	molecular_function	protein dimerization activity
D	0000166	molecular_function	nucleotide binding
D	0000428	cellular_component	DNA-directed RNA polymerase complex
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005665	cellular_component	RNA polymerase II, core complex
D	0005829	cellular_component	cytosol
D	0006352	biological_process	DNA-templated transcription initiation
D	0006366	biological_process	transcription by RNA polymerase II
D	0006367	biological_process	transcription initiation at RNA polymerase II promoter
D	0016607	cellular_component	nuclear speck
D	0030880	cellular_component	RNA polymerase complex
D	0031369	molecular_function	translation initiation factor binding
D	0044237	biological_process	cellular metabolic process
E	0000428	cellular_component	DNA-directed RNA polymerase complex
E	0001054	molecular_function	RNA polymerase I activity
E	0001055	molecular_function	RNA polymerase II activity
E	0001056	molecular_function	RNA polymerase III activity
E	0003677	molecular_function	DNA binding
E	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005665	cellular_component	RNA polymerase II, core complex
E	0005666	cellular_component	RNA polymerase III complex
E	0005730	cellular_component	nucleolus
E	0005736	cellular_component	RNA polymerase I complex
E	0005829	cellular_component	cytosol
E	0006351	biological_process	DNA-templated transcription
E	0006362	biological_process	transcription elongation by RNA polymerase I
E	0006366	biological_process	transcription by RNA polymerase II
E	0042797	biological_process	tRNA transcription by RNA polymerase III
E	0050821	biological_process	protein stabilization
E	1990062	cellular_component	RPAP3/R2TP/prefoldin-like complex
F	0000428	cellular_component	DNA-directed RNA polymerase complex
F	0001054	molecular_function	RNA polymerase I activity
F	0001055	molecular_function	RNA polymerase II activity
F	0001056	molecular_function	RNA polymerase III activity
F	0001650	cellular_component	fibrillar center
F	0003677	molecular_function	DNA binding
F	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005665	cellular_component	RNA polymerase II, core complex
F	0005666	cellular_component	RNA polymerase III complex
F	0005730	cellular_component	nucleolus
F	0005736	cellular_component	RNA polymerase I complex
F	0005829	cellular_component	cytosol
F	0006351	biological_process	DNA-templated transcription
F	0006360	biological_process	transcription by RNA polymerase I
F	0006366	biological_process	transcription by RNA polymerase II
F	0042797	biological_process	tRNA transcription by RNA polymerase III
G	0000428	cellular_component	DNA-directed RNA polymerase complex
G	0000932	cellular_component	P-body
G	0000956	biological_process	nuclear-transcribed mRNA catabolic process
G	0003676	molecular_function	nucleic acid binding
G	0003697	molecular_function	single-stranded DNA binding
G	0003723	molecular_function	RNA binding
G	0003727	molecular_function	single-stranded RNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005665	cellular_component	RNA polymerase II, core complex
G	0006351	biological_process	DNA-templated transcription
G	0006352	biological_process	DNA-templated transcription initiation
G	0006366	biological_process	transcription by RNA polymerase II
G	0006367	biological_process	transcription initiation at RNA polymerase II promoter
G	0031369	molecular_function	translation initiation factor binding
G	0045948	biological_process	positive regulation of translational initiation
G	0060213	biological_process	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
H	0000428	cellular_component	DNA-directed RNA polymerase complex
H	0001054	molecular_function	RNA polymerase I activity
H	0001055	molecular_function	RNA polymerase II activity
H	0001056	molecular_function	RNA polymerase III activity
H	0003677	molecular_function	DNA binding
H	0003697	molecular_function	single-stranded DNA binding
H	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005665	cellular_component	RNA polymerase II, core complex
H	0005666	cellular_component	RNA polymerase III complex
H	0005730	cellular_component	nucleolus
H	0005736	cellular_component	RNA polymerase I complex
H	0005829	cellular_component	cytosol
H	0006351	biological_process	DNA-templated transcription
H	0006360	biological_process	transcription by RNA polymerase I
H	0006366	biological_process	transcription by RNA polymerase II
H	0006383	biological_process	transcription by RNA polymerase III
H	0032993	cellular_component	protein-DNA complex
I	0000428	cellular_component	DNA-directed RNA polymerase complex
I	0001193	biological_process	maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
I	0003676	molecular_function	nucleic acid binding
I	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005665	cellular_component	RNA polymerase II, core complex
I	0005730	cellular_component	nucleolus
I	0006283	biological_process	transcription-coupled nucleotide-excision repair
I	0006351	biological_process	DNA-templated transcription
I	0006366	biological_process	transcription by RNA polymerase II
I	0006367	biological_process	transcription initiation at RNA polymerase II promoter
I	0008270	molecular_function	zinc ion binding
I	0046872	molecular_function	metal ion binding
J	0000428	cellular_component	DNA-directed RNA polymerase complex
J	0001054	molecular_function	RNA polymerase I activity
J	0001055	molecular_function	RNA polymerase II activity
J	0001056	molecular_function	RNA polymerase III activity
J	0003677	molecular_function	DNA binding
J	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005665	cellular_component	RNA polymerase II, core complex
J	0005666	cellular_component	RNA polymerase III complex
J	0005730	cellular_component	nucleolus
J	0005736	cellular_component	RNA polymerase I complex
J	0005829	cellular_component	cytosol
J	0006351	biological_process	DNA-templated transcription
J	0006356	biological_process	regulation of transcription by RNA polymerase I
J	0006360	biological_process	transcription by RNA polymerase I
J	0006366	biological_process	transcription by RNA polymerase II
J	0008270	molecular_function	zinc ion binding
J	0042797	biological_process	tRNA transcription by RNA polymerase III
J	0046872	molecular_function	metal ion binding
K	0000428	cellular_component	DNA-directed RNA polymerase complex
K	0001055	molecular_function	RNA polymerase II activity
K	0003677	molecular_function	DNA binding
K	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005665	cellular_component	RNA polymerase II, core complex
K	0006351	biological_process	DNA-templated transcription
K	0006366	biological_process	transcription by RNA polymerase II
K	0030275	molecular_function	LRR domain binding
K	0046983	molecular_function	protein dimerization activity
L	0000428	cellular_component	DNA-directed RNA polymerase complex
L	0001054	molecular_function	RNA polymerase I activity
L	0001055	molecular_function	RNA polymerase II activity
L	0001056	molecular_function	RNA polymerase III activity
L	0003677	molecular_function	DNA binding
L	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005665	cellular_component	RNA polymerase II, core complex
L	0005666	cellular_component	RNA polymerase III complex
L	0005730	cellular_component	nucleolus
L	0005736	cellular_component	RNA polymerase I complex
L	0005829	cellular_component	cytosol
L	0006351	biological_process	DNA-templated transcription
L	0006356	biological_process	regulation of transcription by RNA polymerase I
L	0006360	biological_process	transcription by RNA polymerase I
L	0006366	biological_process	transcription by RNA polymerase II
L	0006383	biological_process	transcription by RNA polymerase III
L	0008270	molecular_function	zinc ion binding
L	0046872	molecular_function	metal ion binding
M	0000776	cellular_component	kinetochore
M	0000793	cellular_component	condensed chromosome
M	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
M	0000993	molecular_function	RNA polymerase II complex binding
M	0001174	biological_process	transcriptional start site selection at RNA polymerase II promoter
M	0003677	molecular_function	DNA binding
M	0004402	molecular_function	histone acetyltransferase activity
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005669	cellular_component	transcription factor TFIID complex
M	0005694	cellular_component	chromosome
M	0006338	biological_process	chromatin remodeling
M	0006352	biological_process	DNA-templated transcription initiation
M	0006366	biological_process	transcription by RNA polymerase II
M	0006367	biological_process	transcription initiation at RNA polymerase II promoter
M	0006473	biological_process	protein acetylation
M	0008270	molecular_function	zinc ion binding
M	0010467	biological_process	gene expression
M	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
M	0016407	molecular_function	acetyltransferase activity
M	0016604	cellular_component	nuclear body
M	0016746	molecular_function	acyltransferase activity
M	0017025	molecular_function	TBP-class protein binding
M	0019083	biological_process	viral transcription
M	0032153	cellular_component	cell division site
M	0032993	cellular_component	protein-DNA complex
M	0042585	cellular_component	germinal vesicle
M	0046872	molecular_function	metal ion binding
M	0046966	molecular_function	nuclear thyroid hormone receptor binding
M	0051123	biological_process	RNA polymerase II preinitiation complex assembly
M	0051177	biological_process	meiotic sister chromatid cohesion
M	0051225	biological_process	spindle assembly
M	0051276	biological_process	chromosome organization
M	0061733	molecular_function	peptide-lysine-N-acetyltransferase activity
M	0070897	biological_process	transcription preinitiation complex assembly
M	0090575	cellular_component	RNA polymerase II transcription regulator complex
M	0097550	cellular_component	transcription preinitiation complex
M	0140297	molecular_function	DNA-binding transcription factor binding
M	1904798	biological_process	positive regulation of core promoter binding
M	1990114	biological_process	RNA polymerase II core complex assembly
M	1990841	molecular_function	promoter-specific chromatin binding
N	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
N	0001091	molecular_function	RNA polymerase II general transcription initiation factor binding
N	0003677	molecular_function	DNA binding
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005669	cellular_component	transcription factor TFIID complex
N	0005672	cellular_component	transcription factor TFIIA complex
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0006366	biological_process	transcription by RNA polymerase II
N	0006367	biological_process	transcription initiation at RNA polymerase II promoter
N	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
N	0017025	molecular_function	TBP-class protein binding
N	0045944	biological_process	positive regulation of transcription by RNA polymerase II
N	0046982	molecular_function	protein heterodimerization activity
N	0051123	biological_process	RNA polymerase II preinitiation complex assembly
N	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
N	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
N	0097550	cellular_component	transcription preinitiation complex
O	0001091	molecular_function	RNA polymerase II general transcription initiation factor binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005669	cellular_component	transcription factor TFIID complex
O	0005672	cellular_component	transcription factor TFIIA complex
O	0006366	biological_process	transcription by RNA polymerase II
O	0006367	biological_process	transcription initiation at RNA polymerase II promoter
O	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
O	0017025	molecular_function	TBP-class protein binding
O	0030054	cellular_component	cell junction
O	0042803	molecular_function	protein homodimerization activity
O	0045944	biological_process	positive regulation of transcription by RNA polymerase II
O	0046982	molecular_function	protein heterodimerization activity
O	0051123	biological_process	RNA polymerase II preinitiation complex assembly
O	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
O	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
P	0000785	cellular_component	chromatin
P	0000791	cellular_component	euchromatin
P	0000976	molecular_function	transcription cis-regulatory region binding
P	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
P	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
P	0000995	molecular_function	RNA polymerase III general transcription initiation factor activity
P	0001046	molecular_function	core promoter sequence-specific DNA binding
P	0001091	molecular_function	RNA polymerase II general transcription initiation factor binding
P	0001093	molecular_function	TFIIB-class transcription factor binding
P	0001164	molecular_function	RNA polymerase I core promoter sequence-specific DNA binding
P	0001188	biological_process	RNA polymerase I preinitiation complex assembly
P	0001673	cellular_component	male germ cell nucleus
P	0001674	cellular_component	female germ cell nucleus
P	0001939	cellular_component	female pronucleus
P	0001940	cellular_component	male pronucleus
P	0003677	molecular_function	DNA binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005668	cellular_component	RNA polymerase transcription factor SL1 complex
P	0005669	cellular_component	transcription factor TFIID complex
P	0005672	cellular_component	transcription factor TFIIA complex
P	0005737	cellular_component	cytoplasm
P	0006352	biological_process	DNA-templated transcription initiation
P	0006366	biological_process	transcription by RNA polymerase II
P	0006367	biological_process	transcription initiation at RNA polymerase II promoter
P	0006383	biological_process	transcription by RNA polymerase III
P	0007283	biological_process	spermatogenesis
P	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
P	0017162	molecular_function	aryl hydrocarbon receptor binding
P	0019899	molecular_function	enzyme binding
P	0032991	cellular_component	protein-containing complex
P	0042789	biological_process	mRNA transcription by RNA polymerase II
P	0045120	cellular_component	pronucleus
P	0045893	biological_process	positive regulation of DNA-templated transcription
P	0051123	biological_process	RNA polymerase II preinitiation complex assembly
P	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
P	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
P	0140297	molecular_function	DNA-binding transcription factor binding
Q	0001113	biological_process	transcription open complex formation at RNA polymerase II promoter
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005669	cellular_component	transcription factor TFIID complex
Q	0005673	cellular_component	transcription factor TFIIE complex
Q	0005829	cellular_component	cytosol
Q	0006366	biological_process	transcription by RNA polymerase II
Q	0006367	biological_process	transcription initiation at RNA polymerase II promoter
Q	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
Q	0046872	molecular_function	metal ion binding
R	0001097	molecular_function	TFIIH-class transcription factor complex binding
R	0003677	molecular_function	DNA binding
R	0003723	molecular_function	RNA binding
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005669	cellular_component	transcription factor TFIID complex
R	0005673	cellular_component	transcription factor TFIIE complex
R	0005829	cellular_component	cytosol
R	0006366	biological_process	transcription by RNA polymerase II
R	0006367	biological_process	transcription initiation at RNA polymerase II promoter
R	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
S	0001091	molecular_function	RNA polymerase II general transcription initiation factor binding
S	0001096	molecular_function	TFIIF-class transcription factor complex binding
S	0003677	molecular_function	DNA binding
S	0003723	molecular_function	RNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005669	cellular_component	transcription factor TFIID complex
S	0005674	cellular_component	transcription factor TFIIF complex
S	0006366	biological_process	transcription by RNA polymerase II
S	0006367	biological_process	transcription initiation at RNA polymerase II promoter
S	0006368	biological_process	transcription elongation by RNA polymerase II
S	0009615	biological_process	response to virus
S	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
S	0019211	molecular_function	phosphatase activator activity
S	0019903	molecular_function	protein phosphatase binding
S	0019904	molecular_function	protein domain specific binding
S	0030054	cellular_component	cell junction
S	0032091	biological_process	negative regulation of protein binding
S	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
S	0032991	cellular_component	protein-containing complex
S	0043231	cellular_component	intracellular membrane-bounded organelle
S	0045944	biological_process	positive regulation of transcription by RNA polymerase II
S	1990841	molecular_function	promoter-specific chromatin binding
T	0003677	molecular_function	DNA binding
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005674	cellular_component	transcription factor TFIIF complex
T	0006366	biological_process	transcription by RNA polymerase II
T	0006367	biological_process	transcription initiation at RNA polymerase II promoter
T	0006368	biological_process	transcription elongation by RNA polymerase II
T	0015630	cellular_component	microtubule cytoskeleton
T	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
T	0045944	biological_process	positive regulation of transcription by RNA polymerase II
U	0003676	molecular_function	nucleic acid binding
U	0003677	molecular_function	DNA binding
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005669	cellular_component	transcription factor TFIID complex
U	0005730	cellular_component	nucleolus
U	0006351	biological_process	DNA-templated transcription
U	0006366	biological_process	transcription by RNA polymerase II
U	0006368	biological_process	transcription elongation by RNA polymerase II
U	0008270	molecular_function	zinc ion binding
U	0045944	biological_process	positive regulation of transcription by RNA polymerase II
U	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue MG A 2001

Chain	Residue
A	ASN493
A	ASP495
A	ASP499

---

site_id	AC2
Number of Residues	4
Details	binding site for residue MG A 2002

Chain	Residue
A	ALA494
A	ASP495
B	GLU791
U	ASP282

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 2003

Chain	Residue
A	CYS81
A	HIS84
A	CYS71
A	CYS74

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN A 2004

Chain	Residue
A	CYS111
A	CYS114
A	CYS154
A	CYS184

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN B 1201

Chain	Residue
B	CYS1119
B	CYS1122
B	CYS1137
B	CYS1140

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN C 301

Chain	Residue
C	CYS88
C	CYS90
C	CYS94
C	CYS97

---

site_id	AC7
Number of Residues	5
Details	binding site for residue ZN I 201

Chain	Residue
I	CYS17
I	CYS20
I	CYS39
I	ASN41
I	CYS42

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN I 202

Chain	Residue
I	CYS86
I	CYS89
I	CYS114
I	CYS119

---

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN J 101

Chain	Residue
J	CYS7
J	CYS10
J	CYS44
J	CYS45

---

site_id	AD1
Number of Residues	4
Details	binding site for residue ZN L 101

Chain	Residue
L	CYS19
L	CYS22
L	CYS36
L	CYS39

---

site_id	AD2
Number of Residues	6
Details	binding site for residue ZN M 401

Chain	Residue
M	CYS15
M	HIS18
M	CYS34
M	GLU36
M	CYS37
M	LEU39

---

site_id	AD3
Number of Residues	4
Details	binding site for residue ZN Q 501

Chain	Residue
Q	CYS129
Q	CYS132
Q	CYS154
Q	CYS157

---

site_id	AD4
Number of Residues	4
Details	binding site for residue ZN U 401

Chain	Residue
U	CYS263
U	CYS266
U	CYS291
U	CYS294

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DNDPNDYVEqdDI

Chain	Residue	Details
C	ASP136-ILE148

---

site_id	PS00115
Number of Residues	7
Details	RNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPA

Chain	Residue	Details
A	TYR1593-ALA1599
A	TYR1671-SER1677
A	TYR1678-SER1684
A	TYR1685-SER1691
A	TYR1692-SER1698
A	TYR1699-SER1705
A	TYR1706-SER1712
A	TYR1713-SER1719
A	TYR1720-SER1726
A	TYR1727-SER1733
A	TYR1734-SER1740
A	TYR1615-SER1621
A	TYR1741-ASN1747
A	TYR1748-ASN1754
A	TYR1755-SER1761
A	TYR1762-SER1768
A	TYR1769-ASN1775
A	TYR1776-ASN1782
A	TYR1783-SER1789
A	TYR1790-SER1796
A	TYR1797-SER1803
A	TYR1818-SER1824
A	TYR1622-SER1628
A	TYR1825-SER1831
A	TYR1839-SER1845
A	TYR1853-LYS1859
A	TYR1860-LYS1866
A	TYR1867-LYS1873
A	TYR1874-THR1880
A	TYR1888-THR1894
A	TYR1902-LYS1908
A	TYR1909-THR1915
A	TYR1916-LYS1922
A	TYR1629-ASN1635
A	TYR1923-THR1929
A	TYR1930-LYS1936
A	TYR1947-THR1953
A	TYR1636-SER1642
A	TYR1643-SER1649
A	TYR1650-SER1656
A	TYR1657-SER1663
A	TYR1664-SER1670

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YVCTAPH

Chain	Residue	Details
I	TYR112-HIS118

---

site_id	PS00351
Number of Residues	50
Details	TFIID Transcription factor TFIID repeat signature. YnPkrFaaVImRirePRttaLIFsSGKMvctGAKseeqsrlAarkyarvV

Chain	Residue	Details
P	TYR192-VAL241
P	TYR283-LEU332

---

site_id	PS00446
Number of Residues	41
Details	RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NSIRRvfiaevpiiAidwVqidaNsSvlhDEfIAhRLGLIP

Chain	Residue	Details
C	ASN32-PRO72

---

site_id	PS00466
Number of Residues	36
Details	ZF_TFIIS_1 Zinc finger TFIIS-type signature. CgkCkkknctytqVQTRSaDEPmttfvvCne...CgnrW

Chain	Residue	Details
U	CYS263-TRP298
I	CYS86-TRP123

---

site_id	PS00782
Number of Residues	16
Details	TFIIB Transcription factor TFIIB repeat signature. GRandAIASACLYIAC

Chain	Residue	Details
M	GLY153-CYS168
M	GLY247-SER262

---

site_id	PS01030
Number of Residues	27
Details	RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCQECNNMLypkedkenrillyaCrnC

Chain	Residue	Details
I	PHE16-CYS42

---

site_id	PS01110
Number of Residues	14
Details	RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPEHvvMtkEE

Chain	Residue	Details
E	HIS142-GLU155

---

site_id	PS01111
Number of Residues	15
Details	RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARvLGtRAlQ

Chain	Residue	Details
F	THR58-GLN72

---

site_id	PS01112
Number of Residues	10
Details	RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IIPVrCFTCG

Chain	Residue	Details
J	ILE2-GLY11

---

site_id	PS01154
Number of Residues	32
Details	RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. InkEdHTLgNiIksqLlkdpqVlfagYkvpHP

Chain	Residue	Details
K	ILE35-PRO66

---

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT

Chain	Residue	Details
B	GLY932-THR944

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	ZN_FING: TFIIS-type => ECO:0000255|PROSITE-ProRule:PRU00472

Chain	Residue	Details
U	ASP259-LYS299
T	HIS229
S	GLU517
P	ASN257
P	ARG294
A	ARG1416
A	ARG1421

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00472, ECO:0000269|PubMed:27193682, ECO:0000312|PDB:5IY6

Chain	Residue	Details
U	CYS263
A	ASP495
U	CYS266
U	CYS291
U	CYS294
A	CYS111
A	CYS114
A	CYS154
A	CYS184
A	ASN493

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N-acetylmethionine => ECO:0000269|Ref.9, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378

Chain	Residue	Details
U	MET1
T	LYS33
T	LYS137
I	CYS42
B	LYS942
B	ARG1078
B	ARG1085

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
U	SER57
M	THR284
M	ARG286
M	ARG290
U	SER81
M	LYS152
M	ARG154
M	LYS189
M	LYS196
M	ARG248
M	LYS272
M	ALA281

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692

Chain	Residue	Details
U	SER97
S	SER224
A	SER1868

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
U	SER100

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q15560

Chain	Residue	Details
U	LYS55

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	SER377
S	SER431

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
S	SER380
A	THR1933
S	SER381
S	SER436
S	SER449
A	THR1912
A	THR1915
A	THR1919
A	THR1926
A	THR1929

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:10428810, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	SER385

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:10428810, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	THR389
A	SER1857
A	SER1861
A	SER1875

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692

Chain	Residue	Details
S	SER391

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
S	LYS407

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	SER433
A	SER1864

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
S	THR446

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:26566685

Chain	Residue	Details
A	LYS1859
A	LYS1866
A	LYS1873
A	LYS1887

---

site_id	SWS_FT_FI17
Number of Residues	5
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:26566685

Chain	Residue	Details
A	TYR1860
A	TYR1867
A	TYR1881
A	TYR1916
A	TYR1930

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:26566685, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	TYR1874

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:26566685, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER1878
A	SER1882

---

site_id	SWS_FT_FI20
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	THR1885

---

site_id	SWS_FT_FI21
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P08775

Chain	Residue	Details
A	THR1894

---

site_id	SWS_FT_FI22
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
A	SER1896

---

site_id	SWS_FT_FI23
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER1899

---

site_id	SWS_FT_FI24
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER1906

---

site_id	SWS_FT_FI25
Number of Residues	1
Details	MOD_RES: N6,N6-dimethyllysine => ECO:0000250|UniProtKB:P08775

Chain	Residue	Details
A	LYS1908

---

site_id	SWS_FT_FI26
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:26566685, ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	TYR1909
A	TYR1923

---

site_id	SWS_FT_FI27
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:26566685, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER1913
A	SER1920
A	SER1927

---

site_id	SWS_FT_FI28
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:26566685, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692

Chain	Residue	Details
A	SER1917
A	SER1931

---

site_id	SWS_FT_FI29
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000305|PubMed:26566685

Chain	Residue	Details
A	LYS1922
A	LYS1936

---

site_id	SWS_FT_FI30
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER1934

---

site_id	SWS_FT_FI31
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); by NEDD4 => ECO:0000269|PubMed:32142649, ECO:0000305|PubMed:32142654

Chain	Residue	Details
A	LYS1268

---