5IX2

Crystal structure of mouse Morc3 ATPase-CW cassette in complex with AMPPNP and unmodified H3 peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008270	molecular_function	zinc ion binding
A	0016887	molecular_function	ATP hydrolysis activity
B	0008270	molecular_function	zinc ion binding
B	0016887	molecular_function	ATP hydrolysis activity
P	0000786	cellular_component	nucleosome
P	0003677	molecular_function	DNA binding
P	0030527	molecular_function	structural constituent of chromatin
P	0046982	molecular_function	protein heterodimerization activity
Q	0000786	cellular_component	nucleosome
Q	0003677	molecular_function	DNA binding
Q	0030527	molecular_function	structural constituent of chromatin
Q	0046982	molecular_function	protein heterodimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 501

Chain	Residue
A	CYS413
A	CYS416
A	CYS435
A	CYS446

---

site_id	AC2
Number of Residues	20
Details	binding site for residue ANP A 502

Chain	Residue
A	MET72
A	MET80
A	SER86
A	LYS88
A	GLY98
A	LEU99
A	TYR100
A	GLY101
A	ASN102
A	GLY103
A	PHE104
A	LYS105
A	THR194
A	LYS358
A	MG503
A	GLU35
A	ASN39
A	ASP44
A	VAL45
A	ASP67

---

site_id	AC3
Number of Residues	3
Details	binding site for residue MG A 503

Chain	Residue
A	GLU35
A	ASN39
A	ANP502

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN B 501

Chain	Residue
B	CYS413
B	CYS416
B	CYS435
B	CYS446

---

site_id	AC5
Number of Residues	19
Details	binding site for residue ANP B 502

Chain	Residue
B	ASN39
B	ASP44
B	VAL45
B	ASP67
B	MET72
B	MET80
B	SER86
B	LYS88
B	GLY98
B	LEU99
B	TYR100
B	GLY101
B	ASN102
B	GLY103
B	PHE104
B	LYS105
B	THR194
B	LYS358
B	MG503

---

site_id	AC6
Number of Residues	3
Details	binding site for residue MG B 503

Chain	Residue
B	GLU35
B	ASN39
B	ANP502

---

Functional Information from PROSITE/UniProt

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
P	LYS14-LEU20

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoarginine; alternate => ECO:0000305

Chain	Residue	Details
P	ARG2
Q	ARG2

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by HASPIN and VRK1 => ECO:0000250|UniProtKB:P68431, ECO:0000269|PubMed:15681610

Chain	Residue	Details
P	THR3
Q	THR3
A	CYS435
A	CYS446
B	CYS413
B	CYS416
B	CYS435
B	CYS446

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:11747826, ECO:0000269|PubMed:17194708

Chain	Residue	Details
P	LYS4
B	LYS293
Q	LYS4
A	LYS205
A	LYS280
A	LYS293
B	LYS191
B	LYS205
B	LYS280

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594

Chain	Residue	Details
P	GLN5
Q	GLN5

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by PKC => ECO:0000250|UniProtKB:P68431

Chain	Residue	Details
P	THR6
Q	THR6

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000269|PubMed:15485929

Chain	Residue	Details
P	ARG8
Q	ARG8

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:13678296, ECO:0000269|PubMed:17194708

Chain	Residue	Details
P	LYS9
P	LYS27
Q	LYS9
Q	LYS27

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:15735677, ECO:0000269|PubMed:15870105

Chain	Residue	Details
P	SER10
Q	SER10

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by PKC and CHEK1 => ECO:0000250|UniProtKB:P68431

Chain	Residue	Details
P	THR11
Q	THR11

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P68431

Chain	Residue	Details
P	LYS14
Q	LYS14

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: Citrulline; alternate => ECO:0000269|PubMed:15339660

Chain	Residue	Details
P	ARG17
Q	ARG17

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:17194708

Chain	Residue	Details
P	LYS18
P	LYS23
Q	LYS18
Q	LYS23

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	MOD_RES: Citrulline => ECO:0000269|PubMed:15339660

Chain	Residue	Details
P	ARG26
Q	ARG26

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	MOD_RES: Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11441012, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:15735677, ECO:0000269|PubMed:15870105

Chain	Residue	Details
P	SER28
Q	SER28

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	LIPID: N6-decanoyllysine => ECO:0000250|UniProtKB:P68431

Chain	Residue	Details
P	LYS18
Q	LYS18

---