5IX2
Crystal structure of mouse Morc3 ATPase-CW cassette in complex with AMPPNP and unmodified H3 peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| P | 0000786 | cellular_component | nucleosome |
| P | 0003677 | molecular_function | DNA binding |
| P | 0030527 | molecular_function | structural constituent of chromatin |
| P | 0046982 | molecular_function | protein heterodimerization activity |
| Q | 0000786 | cellular_component | nucleosome |
| Q | 0003677 | molecular_function | DNA binding |
| Q | 0030527 | molecular_function | structural constituent of chromatin |
| Q | 0046982 | molecular_function | protein heterodimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 501 |
| Chain | Residue |
| A | CYS413 |
| A | CYS416 |
| A | CYS435 |
| A | CYS446 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | binding site for residue ANP A 502 |
| Chain | Residue |
| A | MET72 |
| A | MET80 |
| A | SER86 |
| A | LYS88 |
| A | GLY98 |
| A | LEU99 |
| A | TYR100 |
| A | GLY101 |
| A | ASN102 |
| A | GLY103 |
| A | PHE104 |
| A | LYS105 |
| A | THR194 |
| A | LYS358 |
| A | MG503 |
| A | GLU35 |
| A | ASN39 |
| A | ASP44 |
| A | VAL45 |
| A | ASP67 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 503 |
| Chain | Residue |
| A | GLU35 |
| A | ASN39 |
| A | ANP502 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 501 |
| Chain | Residue |
| B | CYS413 |
| B | CYS416 |
| B | CYS435 |
| B | CYS446 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | binding site for residue ANP B 502 |
| Chain | Residue |
| B | ASN39 |
| B | ASP44 |
| B | VAL45 |
| B | ASP67 |
| B | MET72 |
| B | MET80 |
| B | SER86 |
| B | LYS88 |
| B | GLY98 |
| B | LEU99 |
| B | TYR100 |
| B | GLY101 |
| B | ASN102 |
| B | GLY103 |
| B | PHE104 |
| B | LYS105 |
| B | THR194 |
| B | LYS358 |
| B | MG503 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue MG B 503 |
| Chain | Residue |
| B | GLU35 |
| B | ASN39 |
| B | ANP502 |
Functional Information from PROSITE/UniProt
| site_id | PS00322 |
| Number of Residues | 7 |
| Details | HISTONE_H3_1 Histone H3 signature 1. KAPRKQL |
| Chain | Residue | Details |
| P | LYS14-LEU20 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 100 |
| Details | Zinc finger: {"description":"CW-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00454","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00454","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27528681","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"UniProtKB","id":"Q14149","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 27 |
| Details | Region: {"description":"Nuclear matrix binding","evidences":[{"source":"UniProtKB","id":"Q14149","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoarginine; alternate","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by HASPIN and VRK1","evidences":[{"source":"UniProtKB","id":"P68431","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"15681610","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"11747826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"5-glutamyl serotonin; alternate","evidences":[{"source":"PubMed","id":"30867594","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by PKC","evidences":[{"source":"UniProtKB","id":"P68431","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Symmetric dimethylarginine; by PRMT5; alternate","evidences":[{"source":"PubMed","id":"15485929","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"13678296","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5","evidences":[{"source":"PubMed","id":"10464286","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11856369","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15681610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15735677","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15870105","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
