5IW8
Mycobacterium tuberculosis CysM in complex with the Urea-scaffold inhibitor 4 [5-(3-([1,1'-Biphenyl]-3-yl)ureido)-2-hydroxybenzoic acid]
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004124 | molecular_function | cysteine synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006535 | biological_process | cysteine biosynthetic process from serine |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0019344 | biological_process | cysteine biosynthetic process |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0033847 | molecular_function | O-phosphoserine sulfhydrylase activity |
| B | 0004124 | molecular_function | cysteine synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006535 | biological_process | cysteine biosynthetic process from serine |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0019344 | biological_process | cysteine biosynthetic process |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0033847 | molecular_function | O-phosphoserine sulfhydrylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue 6EC A 401 |
| Chain | Residue |
| A | LYS51 |
| A | VAL242 |
| A | ALA247 |
| A | ILE264 |
| A | SER265 |
| A | ALA268 |
| A | PLP403 |
| A | HOH567 |
| A | HOH606 |
| A | HOH637 |
| A | GLY80 |
| A | ASN81 |
| A | THR82 |
| A | GLN151 |
| A | TYR152 |
| A | GLY184 |
| A | ALA208 |
| A | PRO210 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 402 |
| Chain | Residue |
| A | ALA140 |
| A | ASN143 |
| A | TRP146 |
| A | HOH603 |
| A | HOH654 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | binding site for residue PLP A 403 |
| Chain | Residue |
| A | LYS51 |
| A | ASN81 |
| A | GLY182 |
| A | GLY184 |
| A | THR185 |
| A | THR186 |
| A | GLY187 |
| A | THR188 |
| A | SER265 |
| A | ALA294 |
| A | ASP295 |
| A | 6EC401 |
| A | HOH521 |
| A | HOH556 |
| A | HOH583 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | binding site for residue 6EC B 401 |
| Chain | Residue |
| B | LYS51 |
| B | SER79 |
| B | GLY80 |
| B | ASN81 |
| B | THR82 |
| B | ARG109 |
| B | GLN151 |
| B | TYR152 |
| B | GLY184 |
| B | ALA208 |
| B | PRO210 |
| B | LEU219 |
| B | ASN221 |
| B | VAL242 |
| B | ALA247 |
| B | ALA268 |
| B | PLP402 |
| B | HOH580 |
| site_id | AC5 |
| Number of Residues | 22 |
| Details | binding site for Di-peptide PLP B 402 and LYS B 51 |
| Chain | Residue |
| B | SER49 |
| B | ILE50 |
| B | ASP52 |
| B | ARG53 |
| B | PRO54 |
| B | ALA55 |
| B | ASN81 |
| B | THR82 |
| B | SER85 |
| B | GLY182 |
| B | GLY184 |
| B | THR185 |
| B | THR186 |
| B | GLY187 |
| B | THR188 |
| B | SER265 |
| B | ALA294 |
| B | ASP295 |
| B | 6EC401 |
| B | HOH551 |
| B | HOH608 |
| B | HOH649 |
Functional Information from PROSITE/UniProt
| site_id | PS00901 |
| Number of Residues | 19 |
| Details | CYS_SYNTHASE Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. KlEdrn.PTgSIKdRpAvrM |
| Chain | Residue | Details |
| A | LYS40-MET58 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18771296, ECO:0000269|PubMed:18799456, ECO:0000269|PubMed:19101553 |
| Chain | Residue | Details |
| A | ASN81 | |
| A | SER265 | |
| B | ASN81 | |
| B | SER265 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | GLY184 | |
| B | GLY184 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305 |
| Chain | Residue | Details |
| A | ARG220 | |
| B | ARG220 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-(pyridoxal phosphate)lysine |
| Chain | Residue | Details |
| A | LYS51 | |
| B | LYS51 |
