5IVT
Crystal Structure of HIV Protease complexed with [(1S)-1-[(S)-(4-chlorophenyl)-(3,5-difluorophenyl)methyl]-2-[[5-fluoro-4-[2-[(2R,5S)-5-(2,2,2-trifluoroethylcarbamoyloxymethyl)morpholin-4-ium-2-yl]ethyl]pyridin-1-ium-3-yl]amino]-2-oxo-ethyl]ammonium
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue ACT A 101 |
| Chain | Residue |
| A | ALA28 |
| A | ASP29 |
| A | ASP30 |
| A | ILE47 |
| A | 6EE102 |
| B | 6EE101 |
| site_id | AC2 |
| Number of Residues | 30 |
| Details | binding site for residue 6EE A 102 |
| Chain | Residue |
| A | GLY27 |
| A | ALA28 |
| A | ASP29 |
| A | ASP30 |
| A | VAL32 |
| A | GLY48 |
| A | GLY49 |
| A | ILE50 |
| A | VAL82 |
| A | ILE84 |
| A | ACT101 |
| A | HOH225 |
| B | ARG8 |
| B | LEU23 |
| B | ASP25 |
| B | GLY27 |
| B | GLY48 |
| B | GLY49 |
| B | ILE50 |
| B | PRO81 |
| B | ILE84 |
| B | 6EE101 |
| B | ACT102 |
| B | HOH203 |
| B | HOH228 |
| B | HOH242 |
| B | HOH303 |
| A | ARG8 |
| A | LEU23 |
| A | ASP25 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 103 |
| Chain | Residue |
| A | THR74 |
| A | ASN88 |
| A | HOH282 |
| B | ARG41 |
| site_id | AC4 |
| Number of Residues | 28 |
| Details | binding site for residue 6EE B 101 |
| Chain | Residue |
| A | ARG8 |
| A | LEU23 |
| A | ASP25 |
| A | GLY27 |
| A | GLY48 |
| A | GLY49 |
| A | ILE50 |
| A | PRO81 |
| A | VAL82 |
| A | ILE84 |
| A | ACT101 |
| A | 6EE102 |
| B | ARG8 |
| B | LEU23 |
| B | ASP25 |
| B | GLY27 |
| B | ALA28 |
| B | ASP29 |
| B | ASP30 |
| B | VAL32 |
| B | GLY48 |
| B | GLY49 |
| B | ILE50 |
| B | VAL82 |
| B | ILE84 |
| B | ACT102 |
| B | HOH228 |
| B | HOH260 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue ACT B 102 |
| Chain | Residue |
| A | 6EE102 |
| B | ALA28 |
| B | ASP29 |
| B | ASP30 |
| B | ILE47 |
| B | GLY48 |
| B | 6EE101 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 103 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI |
| Chain | Residue | Details |
| A | ALA22-ILE33 | |
