Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5IUX

GLIC-V135C bimane labelled X-ray structure

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue LMT A 501

Chain	Residue
A	ASP31
A	ILE240
A	ASN245
B	LYS33
B	LMT602
E	LMT403

site_id	AC2
Number of Residues	6
Details	binding site for residue PC1 A 502

Chain	Residue
A	PHE303
A	ASN307
A	PHE315
A	PHE121
A	TYR194
A	TYR254

site_id	AC3
Number of Residues	8
Details	binding site for residue PC1 A 503

Chain	Residue
A	PHE265
A	ARG287
A	ILE291
A	ALA294
A	SER295
A	ALA298
A	PHE299
A	PC1504

site_id	AC4
Number of Residues	5
Details	binding site for residue PC1 A 504

Chain	Residue
A	TYR278
A	GLU282
A	PC1503
A	HOH602
E	PRO300

site_id	AC5
Number of Residues	5
Details	binding site for residue ACT A 505

Chain	Residue
A	ARG77
A	ILE131
A	GLU181
E	PHE42
E	ARG105

site_id	AC6
Number of Residues	8
Details	binding site for residue LMT A 506

Chain	Residue
A	SER230
A	ILE233
B	SER230
B	ILE233
C	SER230
C	ILE233
D	ILE233
E	SER230

site_id	AC7
Number of Residues	8
Details	binding site for residue 6E3 A 507

Chain	Residue
A	VAL5
A	PRO7
A	TRP72
A	GLU75
A	CYS135
A	HOH609
E	VAL90
E	ASP91

site_id	AC8
Number of Residues	1
Details	binding site for residue BR A 508

Chain	Residue
A	PHE78

site_id	AC9
Number of Residues	4
Details	binding site for residue ACT A 509

Chain	Residue
A	ILE73
A	PRO74
A	ILE76
A	ARG85

site_id	AD1
Number of Residues	6
Details	binding site for residue ACT A 510

Chain	Residue
A	ILE25
A	PHE42
A	ARG105
B	ARG77
B	ILE131
B	GLU181

site_id	AD2
Number of Residues	9
Details	binding site for residue PC1 B 601

Chain	Residue
A	PHE210
A	TRP217
A	PHE303
A	LEU304
B	TYR278
B	LEU279
B	GLU282
B	PC1604
B	HOH708

site_id	AD3
Number of Residues	9
Details	binding site for residue LMT B 602

Chain	Residue
A	LMT501
B	ASP31
B	ILE240
B	THR244
B	ASN245
B	HOH707
C	LYS33
C	THR244
C	LMT602

site_id	AD4
Number of Residues	5
Details	binding site for residue PC1 B 603

Chain	Residue
B	ARG118
B	TYR194
B	TYR254
B	ASN307
B	PHE315

site_id	AD5
Number of Residues	6
Details	binding site for residue PC1 B 604

Chain	Residue
B	PHE265
B	GLU272
B	ILE291
B	ALA294
B	ALA298
B	PC1601

site_id	AD6
Number of Residues	2
Details	binding site for residue BR B 605

Chain	Residue
B	PHE78
B	ARG85

site_id	AD7
Number of Residues	3
Details	binding site for residue NA B 606

Chain	Residue
B	PRO68
B	ILE71
B	ILE73

site_id	AD8
Number of Residues	6
Details	binding site for residue ACT B 607

Chain	Residue
B	ILE73
B	PRO74
B	ILE76
B	ARG85
B	TYR102
B	GLU104

site_id	AD9
Number of Residues	4
Details	binding site for residue PC1 C 601

Chain	Residue
C	LEU279
C	GLU282
B	TRP217
C	TYR278

site_id	AE1
Number of Residues	6
Details	binding site for residue LMT C 602

Chain	Residue
B	LMT602
C	ILE240
C	THR244
C	ASN245
D	LYS33
E	LMT402

site_id	AE2
Number of Residues	7
Details	binding site for residue PC1 C 603

Chain	Residue
C	ARG118
C	PHE121
C	GLU163
C	TYR194
C	TYR254
C	ASN307
C	PHE315

site_id	AE3
Number of Residues	7
Details	binding site for residue PC1 C 604

Chain	Residue
C	PHE265
C	ARG287
C	SER290
C	ILE291
C	SER295
C	ALA298
C	PHE299

site_id	AE4
Number of Residues	2
Details	binding site for residue BR C 605

Chain	Residue
C	PHE78
C	ARG85

site_id	AE5
Number of Residues	2
Details	binding site for residue NA C 606

Chain	Residue
C	PRO68
C	ILE71

site_id	AE6
Number of Residues	6
Details	binding site for residue ACT C 607

Chain	Residue
C	PRO74
C	GLU75
C	ILE76
C	ARG85
C	TYR102
C	GLU104

site_id	AE7
Number of Residues	5
Details	binding site for residue ACT C 608

Chain	Residue
B	PHE42
B	ARG105
C	ARG77
C	ILE131
C	GLU181

site_id	AE8
Number of Residues	6
Details	binding site for residue PC1 D 601

Chain	Residue
C	PHE210
C	TRP217
C	PRO300
D	TYR278
D	GLU282
D	GLN284

site_id	AE9
Number of Residues	6
Details	binding site for residue PC1 D 602

Chain	Residue
D	ARG118
D	PHE121
D	TYR194
D	TYR254
D	ASN307
D	PHE315

site_id	AF1
Number of Residues	4
Details	binding site for residue PC1 D 603

Chain	Residue
D	VAL268
D	ARG287
D	ALA294
D	ALA298

site_id	AF2
Number of Residues	1
Details	binding site for residue BR D 605

Chain	Residue
D	PHE78

site_id	AF3
Number of Residues	5
Details	binding site for residue NA D 606

Chain	Residue
D	VAL5
D	PRO68
D	ILE71
D	TRP72
D	ILE73

site_id	AF4
Number of Residues	4
Details	binding site for residue ACT D 607

Chain	Residue
D	ILE73
D	PRO74
D	ILE76
D	ARG85

site_id	AF5
Number of Residues	5
Details	binding site for residue ACT D 608

Chain	Residue
C	PHE42
C	ARG105
D	ARG77
D	ILE131
D	GLU181

site_id	AF6
Number of Residues	5
Details	binding site for residue ACT E 401

Chain	Residue
D	PHE42
D	ARG105
E	ARG77
E	ILE131
E	GLU181

site_id	AF7
Number of Residues	6
Details	binding site for residue LMT E 402

Chain	Residue
C	LMT602
D	ILE240
D	THR244
E	LYS33
E	THR244
E	LMT403

site_id	AF8
Number of Residues	8
Details	binding site for residue LMT E 403

Chain	Residue
A	LMT501
E	ASP31
E	ASP32
E	LYS33
E	ILE240
E	THR244
E	ASN245
E	LMT402

site_id	AF9
Number of Residues	6
Details	binding site for residue PC1 E 404

Chain	Residue
D	PHE210
D	TRP217
E	THR274
E	TYR278
E	GLU282
E	PC1406

site_id	AG1
Number of Residues	5
Details	binding site for residue PC1 E 405

Chain	Residue
E	ARG118
E	PHE121
E	TYR194
E	TYR254
E	ASN307

site_id	AG2
Number of Residues	7
Details	binding site for residue PC1 E 406

Chain	Residue
E	PHE265
E	ARG287
E	ILE291
E	ALA294
E	SER295
E	PHE299
E	PC1404

site_id	AG3
Number of Residues	1
Details	binding site for residue BR E 407

Chain	Residue
E	PHE78

site_id	AG4
Number of Residues	3
Details	binding site for residue NA E 408

Chain	Residue
E	VAL5
E	PRO68
E	ILE71

site_id	AG5
Number of Residues	5
Details	binding site for residue ACT E 409

Chain	Residue
E	PRO74
E	GLU75
E	ILE76
E	ARG85
E	TYR102

site_id	AG6
Number of Residues	12
Details	binding site for Di-peptide 6E3 D 604 and CYS D 135

Chain	Residue
C	THR65
C	VAL90
C	ASP91
C	HOH720
D	TRP72
D	GLU75
D	SER134
D	ASP136
D	THR137
D	ARG138
D	ASN139
D	ILE140

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	370
Details	Transmembrane: {"description":"Helical"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	20
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	35
Details	Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)