5ISY

Crystal structure of Nudix family protein with NAD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000210	molecular_function	NAD+ diphosphatase activity
A	0000287	molecular_function	magnesium ion binding
A	0006402	biological_process	mRNA catabolic process
A	0006742	biological_process	NADP+ catabolic process
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
A	0019677	biological_process	NAD+ catabolic process
A	0030145	molecular_function	manganese ion binding
A	0035529	molecular_function	NADH pyrophosphatase activity
A	0042803	molecular_function	protein homodimerization activity
A	0046872	molecular_function	metal ion binding
A	0048255	biological_process	mRNA stabilization
A	0110153	molecular_function	RNA NAD-cap (NMN-forming) hydrolase activity
A	0110155	biological_process	NAD-cap decapping
C	0000210	molecular_function	NAD+ diphosphatase activity
C	0000287	molecular_function	magnesium ion binding
C	0006402	biological_process	mRNA catabolic process
C	0006742	biological_process	NADP+ catabolic process
C	0008270	molecular_function	zinc ion binding
C	0016787	molecular_function	hydrolase activity
C	0019677	biological_process	NAD+ catabolic process
C	0030145	molecular_function	manganese ion binding
C	0035529	molecular_function	NADH pyrophosphatase activity
C	0042803	molecular_function	protein homodimerization activity
C	0046872	molecular_function	metal ion binding
C	0048255	biological_process	mRNA stabilization
C	0110153	molecular_function	RNA NAD-cap (NMN-forming) hydrolase activity
C	0110155	biological_process	NAD-cap decapping

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 301

Chain	Residue
A	CYS98
A	CYS101
A	CYS116
A	CYS119

---

site_id	AC2
Number of Residues	15
Details	binding site for residue NAD A 302

Chain	Residue
A	PHE196
A	SER199
A	MET201
A	THR239
A	VAL240
A	ALA241
A	HOH413
A	HOH474
C	GLU111
C	TYR124
A	CYS130
A	ILE132
A	PHE160
A	GLN192
A	TRP194

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN C 301

Chain	Residue
C	CYS98
C	CYS101
C	CYS116
C	CYS119

---

site_id	AC4
Number of Residues	12
Details	binding site for residue NAD C 302

Chain	Residue
A	GLU111
A	TYR124
C	ALA128
C	CYS130
C	PHE160
C	TRP194
C	PHE196
C	SER199
C	MET201
C	VAL240
C	ALA241
C	HOH470

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	246
Details	Domain: {"description":"Nudix hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	42
Details	Motif: {"description":"Nudix box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27428510","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IW4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27428510","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IW5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27428510","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27561816","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of NADH pyrophosphatase (1790429) from Escherichia coli K12 at 2.20 A resolution.","authoringGroup":["Joint center for structural genomics (JCSG)"]}},{"source":"PDB","id":"1VK6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GB5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ISY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IW4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IW5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27561816","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ISY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27428510","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27561816","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ISY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IW4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9DCN1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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