Functional Information from GO Data
Chain | GOid | namespace | contents |
X | 0004146 | molecular_function | dihydrofolate reductase activity |
X | 0006730 | biological_process | one-carbon metabolic process |
X | 0016491 | molecular_function | oxidoreductase activity |
X | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
X | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 17 |
Details | binding site for residue U06 X 201 |
Chain | Residue |
X | LEU5 |
X | ILE50 |
X | LEU54 |
X | PHE92 |
X | THR111 |
X | XNP202 |
X | NAP203 |
X | HOH303 |
X | HOH384 |
X | VAL6 |
X | ALA7 |
X | ASN18 |
X | LEU20 |
X | ASP27 |
X | LEU28 |
X | VAL31 |
X | SER49 |
site_id | AC2 |
Number of Residues | 28 |
Details | binding site for residue XNP X 202 |
Chain | Residue |
X | ILE14 |
X | ASN18 |
X | GLN19 |
X | LEU20 |
X | GLY43 |
X | ARG44 |
X | LYS45 |
X | THR46 |
X | LEU62 |
X | THR63 |
X | SER64 |
X | SER67 |
X | GLY94 |
X | GLN95 |
X | THR96 |
X | LEU97 |
X | GLU100 |
X | THR121 |
X | U06201 |
X | NAP203 |
X | HOH306 |
X | HOH307 |
X | HOH314 |
X | HOH318 |
X | HOH319 |
X | HOH353 |
X | HOH387 |
X | HOH400 |
site_id | AC3 |
Number of Residues | 34 |
Details | binding site for residue NAP X 203 |
Chain | Residue |
X | VAL6 |
X | ALA7 |
X | ILE14 |
X | GLY15 |
X | GLN19 |
X | GLY43 |
X | ARG44 |
X | LYS45 |
X | THR46 |
X | LEU62 |
X | THR63 |
X | SER64 |
X | HIS77 |
X | ILE79 |
X | PHE92 |
X | GLY93 |
X | GLY94 |
X | GLN95 |
X | THR96 |
X | LEU97 |
X | GLU100 |
X | THR121 |
X | U06201 |
X | XNP202 |
X | HOH306 |
X | HOH314 |
X | HOH318 |
X | HOH319 |
X | HOH341 |
X | HOH353 |
X | HOH376 |
X | HOH387 |
X | HOH394 |
X | HOH406 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 23 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGfenqLPWhlpn.DlknVkklS |
Chain | Residue | Details |
X | VAL13-SER35 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
X | LEU5 | |
X | ASP27 | |
X | SER49 | |
X | ARG57 | |
X | PHE92 | |
Chain | Residue | Details |
X | VAL6 | |
X | ILE14 | |
X | GLY43 | |
X | LEU62 | |
X | GLU100 | |
X | THR121 | |