5IR5

Crystal structure of wild-type bacterial lipoxygenase from Pseudomonas aeruginosa PA-LOX with space group P21212 at 1.9 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016702	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
A	0034440	biological_process	lipid oxidation
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue FE2 A 701

Chain	Residue
A	HIS377
A	HIS382
A	HIS555
A	ASN559
A	ILE685
A	HOH801

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site_id	AC2
Number of Residues	16
Details	binding site for residue ZPE A 702

Chain	Residue
A	ASP190
A	GLU373
A	HIS382
A	PHE415
A	ILE416
A	ARG422
A	ILE423
A	LEU424
A	ASN607
A	ILE685
A	HOH836
A	HOH861
A	HOH990
A	LEU182
A	VAL185
A	GLY186

---

site_id	AC3
Number of Residues	3
Details	binding site for residue GOL A 703

Chain	Residue
A	THR659
A	THR662
A	HOH1042

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site_id	AC4
Number of Residues	6
Details	binding site for residue GOL A 704

Chain	Residue
A	GLU99
A	GLN393
A	ALA407
A	PHE410
A	GLU411
A	HOH951

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site_id	AC5
Number of Residues	7
Details	binding site for residue GOL A 705

Chain	Residue
A	ALA516
A	VAL519
A	GLY520
A	PRO533
A	LYS654
A	HOH822
A	HOH1104

---

site_id	AC6
Number of Residues	3
Details	binding site for residue NA A 706

Chain	Residue
A	HOH1108
A	HOH1173
A	HOH1244

---

Functional Information from PROSITE/UniProt

site_id	PS00081
Number of Residues	11
Details	LIPOXYGENASE_2 Lipoxygenases iron-binding region signature 2. SHPLhVLLaPH

Chain	Residue	Details
A	SER399-HIS409

---

site_id	PS00711
Number of Residues	15
Details	LIPOXYGENASE_1 Lipoxygenases iron-binding region signature 1. HEmfvHlAQTHLVsE

Chain	Residue	Details
A	HIS372-GLU386

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27500637","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IR4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00726","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27500637","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IR4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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