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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5IPS

Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 4

Functional Information from GO Data
ChainGOidnamespacecontents
A0004972molecular_functionNMDA glutamate receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0007268biological_processchemical synaptic transmission
A0010043biological_processresponse to zinc ion
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0015280molecular_functionligand-gated sodium channel activity
A0016020cellular_componentmembrane
A0017146cellular_componentNMDA selective glutamate receptor complex
A0019722biological_processcalcium-mediated signaling
A0022849molecular_functionglutamate-gated calcium ion channel activity
A0034220biological_processmonoatomic ion transmembrane transport
A0035235biological_processionotropic glutamate receptor signaling pathway
A0035725biological_processsodium ion transmembrane transport
A0038023molecular_functionsignaling receptor activity
A0042391biological_processregulation of membrane potential
A0043005cellular_componentneuron projection
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0046872molecular_functionmetal ion binding
A0048167biological_processregulation of synaptic plasticity
A0070588biological_processcalcium ion transmembrane transport
A0097060cellular_componentsynaptic membrane
A0098839cellular_componentpostsynaptic density membrane
B0005216molecular_functionmonoatomic ion channel activity
B0006811biological_processmonoatomic ion transport
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0016020cellular_componentmembrane
B0038023molecular_functionsignaling receptor activity
C0004972molecular_functionNMDA glutamate receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0007268biological_processchemical synaptic transmission
C0010043biological_processresponse to zinc ion
C0015276molecular_functionligand-gated monoatomic ion channel activity
C0015280molecular_functionligand-gated sodium channel activity
C0016020cellular_componentmembrane
C0017146cellular_componentNMDA selective glutamate receptor complex
C0019722biological_processcalcium-mediated signaling
C0022849molecular_functionglutamate-gated calcium ion channel activity
C0034220biological_processmonoatomic ion transmembrane transport
C0035235biological_processionotropic glutamate receptor signaling pathway
C0035725biological_processsodium ion transmembrane transport
C0038023molecular_functionsignaling receptor activity
C0042391biological_processregulation of membrane potential
C0043005cellular_componentneuron projection
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0046872molecular_functionmetal ion binding
C0048167biological_processregulation of synaptic plasticity
C0070588biological_processcalcium ion transmembrane transport
C0097060cellular_componentsynaptic membrane
C0098839cellular_componentpostsynaptic density membrane
D0005216molecular_functionmonoatomic ion channel activity
D0006811biological_processmonoatomic ion transport
D0015276molecular_functionligand-gated monoatomic ion channel activity
D0016020cellular_componentmembrane
D0038023molecular_functionsignaling receptor activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P35439","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"25008524","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28232581","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UOW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"25008524","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27916457","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28232581","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UOW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UP2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"21677647","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25008524","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28232581","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3QEK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QEL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QEM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UOW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UP2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"21677647","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27916457","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3QEK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TPZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues9
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"21677647","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3QEK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QEL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QEM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q00960","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25008524","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q00959","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"25008524","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28232581","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UOW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UP2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"25008524","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28232581","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TLM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UOW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UP2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

242500

PDB entries from 2025-10-01

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