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5IOV

Cryo-EM structure of GluN1/GluN2B NMDA receptor in the glutamate/glycine/Ro25-6981-bound conformation

Functional Information from GO Data
ChainGOidnamespacecontents
A0004972molecular_functionNMDA glutamate receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0007215biological_processglutamate receptor signaling pathway
A0010043biological_processresponse to zinc ion
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0016020cellular_componentmembrane
A0017146cellular_componentNMDA selective glutamate receptor complex
A0022824molecular_functiontransmitter-gated monoatomic ion channel activity
A0034220biological_processmonoatomic ion transmembrane transport
A0035235biological_processionotropic glutamate receptor signaling pathway
A0038023molecular_functionsignaling receptor activity
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0046872molecular_functionmetal ion binding
B0005216molecular_functionmonoatomic ion channel activity
B0006811biological_processmonoatomic ion transport
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0016020cellular_componentmembrane
B0038023molecular_functionsignaling receptor activity
C0004972molecular_functionNMDA glutamate receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0007215biological_processglutamate receptor signaling pathway
C0010043biological_processresponse to zinc ion
C0015276molecular_functionligand-gated monoatomic ion channel activity
C0016020cellular_componentmembrane
C0017146cellular_componentNMDA selective glutamate receptor complex
C0022824molecular_functiontransmitter-gated monoatomic ion channel activity
C0034220biological_processmonoatomic ion transmembrane transport
C0035235biological_processionotropic glutamate receptor signaling pathway
C0038023molecular_functionsignaling receptor activity
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0046872molecular_functionmetal ion binding
D0005216molecular_functionmonoatomic ion channel activity
D0006811biological_processmonoatomic ion transport
D0015276molecular_functionligand-gated monoatomic ion channel activity
D0016020cellular_componentmembrane
D0038023molecular_functionsignaling receptor activity
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue GLY A 901
ChainResidue
APRO514
ALEU515
ATHR516
ASER678

site_idAC2
Number of Residues2
Detailsbinding site for residue GLY C 1001
ChainResidue
CTHR516
CSER678

site_idAC3
Number of Residues7
Detailsbinding site for residue QEM B 901
ChainResidue
BGLN105
BPHE109
BTYR170
BPHE171
APRO106
ATYR109
BALA102

site_idAC4
Number of Residues4
Detailsbinding site for residue GLU B 902
ChainResidue
BSER505
BGLY672
BSER673
BASP715

site_idAC5
Number of Residues7
Detailsbinding site for residue QEM D 901
ChainResidue
CTYR109
CSER132
DALA102
DILE106
DPHE109
DTYR170
DPHE171

site_idAC6
Number of Residues2
Detailsbinding site for residue GLU D 902
ChainResidue
DSER505
DTHR674

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1408
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:25008524
ChainResidueDetails
BGLN25-MET554
BASP644-PHE819
DGLN25-MET554
DASP644-PHE819
CPHE629-LEU645
CALA811-ALA831

site_idSWS_FT_FI2
Number of Residues66
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:25008524
ChainResidueDetails
BMET555-PHE573
BSER628-VAL643
DMET555-PHE573
DSER628-VAL643

site_idSWS_FT_FI3
Number of Residues64
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:25008524
ChainResidueDetails
BSER574-SER600
BPHE621-ALA627
DSER574-SER600
DPHE621-ALA627

site_idSWS_FT_FI4
Number of Residues38
DetailsINTRAMEM: Discontinuously helical => ECO:0000269|PubMed:25008524
ChainResidueDetails
BLEU601-PHE620
DLEU601-PHE620

site_idSWS_FT_FI5
Number of Residues38
DetailsTRANSMEM: Helical => ECO:0000250|UniProtKB:Q00960
ChainResidueDetails
AHIS67
AHIS94
AASP100
CHIS67
CHIS94
CASP100

site_idSWS_FT_FI6
Number of Residues2
DetailsBINDING: BINDING => ECO:0000305|PubMed:25008524
ChainResidueDetails
BGLU511
DGLU511
AGLN686
AALA730
CPRO514
CARG521
CGLN686
CALA730

site_idSWS_FT_FI7
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q00960
ChainResidueDetails
BVAL516
BCYS729
DVAL516
DCYS729

site_idSWS_FT_FI8
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q00959
ChainResidueDetails
BSER687
DSER687

site_idSWS_FT_FI9
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:25008524, ECO:0000269|PubMed:28232581, ECO:0007744|PDB:4TLL, ECO:0007744|PDB:5UOW, ECO:0007744|PDB:5UP2
ChainResidueDetails
BASN336
DASN336

site_idSWS_FT_FI10
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:25008524, ECO:0000269|PubMed:28232581, ECO:0007744|PDB:4TLM, ECO:0007744|PDB:5UOW, ECO:0007744|PDB:5UP2
ChainResidueDetails
BMET685
DMET685

site_idSWS_FT_FI11
Number of Residues10
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
ChainResidueDetails
AGLN350
CSER769
AASP440
AASP469
AASN489
ASER769
CGLN350
CASP440
CASP469
CASN489

site_idSWS_FT_FI12
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21677647, ECO:0007744|PDB:3QEK, ECO:0007744|PDB:3QEL, ECO:0007744|PDB:3QEM
ChainResidueDetails
AASP368
CASP368

222624

PDB entries from 2024-07-17

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