5IOU
Cryo-EM structure of GluN1/GluN2B NMDA receptor in the glutamate/glycine-bound conformation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004972 | molecular_function | NMDA glutamate receptor activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0010043 | biological_process | response to zinc ion |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0015280 | molecular_function | ligand-gated sodium channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0017146 | cellular_component | NMDA selective glutamate receptor complex |
| A | 0019722 | biological_process | calcium-mediated signaling |
| A | 0022849 | molecular_function | glutamate-gated calcium ion channel activity |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0035235 | biological_process | ionotropic glutamate receptor signaling pathway |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0038023 | molecular_function | signaling receptor activity |
| A | 0045202 | cellular_component | synapse |
| A | 0045211 | cellular_component | postsynaptic membrane |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048167 | biological_process | regulation of synaptic plasticity |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0098839 | cellular_component | postsynaptic density membrane |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0038023 | molecular_function | signaling receptor activity |
| C | 0004972 | molecular_function | NMDA glutamate receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0010043 | biological_process | response to zinc ion |
| C | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| C | 0015280 | molecular_function | ligand-gated sodium channel activity |
| C | 0016020 | cellular_component | membrane |
| C | 0017146 | cellular_component | NMDA selective glutamate receptor complex |
| C | 0019722 | biological_process | calcium-mediated signaling |
| C | 0022849 | molecular_function | glutamate-gated calcium ion channel activity |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0035235 | biological_process | ionotropic glutamate receptor signaling pathway |
| C | 0035725 | biological_process | sodium ion transmembrane transport |
| C | 0038023 | molecular_function | signaling receptor activity |
| C | 0045202 | cellular_component | synapse |
| C | 0045211 | cellular_component | postsynaptic membrane |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0048167 | biological_process | regulation of synaptic plasticity |
| C | 0070588 | biological_process | calcium ion transmembrane transport |
| C | 0098839 | cellular_component | postsynaptic density membrane |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| D | 0016020 | cellular_component | membrane |
| D | 0038023 | molecular_function | signaling receptor activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue GLY A 901 |
| Chain | Residue |
| A | PRO514 |
| A | LEU515 |
| A | THR516 |
| A | SER678 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue GLY C 1001 |
| Chain | Residue |
| C | PRO514 |
| C | THR516 |
| C | SER678 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue GLU B 2001 |
| Chain | Residue |
| B | SER673 |
| B | ASP715 |
| B | SER505 |
| B | GLY672 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue GLU D 901 |
| Chain | Residue |
| D | SER505 |
| D | THR674 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1408 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:25008524 |
| Chain | Residue | Details |
| B | GLN25-MET554 | |
| B | ASP644-PHE819 | |
| D | GLN25-MET554 | |
| D | ASP644-PHE819 | |
| C | PHE629-LEU645 | |
| C | ALA811-ALA831 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 66 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:25008524 |
| Chain | Residue | Details |
| B | MET555-PHE573 | |
| B | SER628-VAL643 | |
| D | MET555-PHE573 | |
| D | SER628-VAL643 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 64 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:25008524 |
| Chain | Residue | Details |
| B | SER574-SER600 | |
| B | PHE621-ALA627 | |
| D | SER574-SER600 | |
| D | PHE621-ALA627 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 38 |
| Details | INTRAMEM: Discontinuously helical => ECO:0000269|PubMed:25008524 |
| Chain | Residue | Details |
| B | LEU601-PHE620 | |
| D | LEU601-PHE620 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 38 |
| Details | TRANSMEM: Helical => ECO:0000250|UniProtKB:Q00960 |
| Chain | Residue | Details |
| A | HIS67 | |
| A | HIS94 | |
| A | ASP100 | |
| C | HIS67 | |
| C | HIS94 | |
| C | ASP100 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:25008524 |
| Chain | Residue | Details |
| B | GLU511 | |
| D | GLU511 | |
| A | GLN686 | |
| A | ALA730 | |
| C | PRO514 | |
| C | ARG521 | |
| C | GLN686 | |
| C | ALA730 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q00960 |
| Chain | Residue | Details |
| B | VAL516 | |
| B | CYS729 | |
| D | VAL516 | |
| D | CYS729 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q00959 |
| Chain | Residue | Details |
| B | SER687 | |
| D | SER687 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:25008524, ECO:0000269|PubMed:28232581, ECO:0007744|PDB:4TLL, ECO:0007744|PDB:5UOW, ECO:0007744|PDB:5UP2 |
| Chain | Residue | Details |
| B | ASN336 | |
| D | ASN336 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:25008524, ECO:0000269|PubMed:28232581, ECO:0007744|PDB:4TLM, ECO:0007744|PDB:5UOW, ECO:0007744|PDB:5UP2 |
| Chain | Residue | Details |
| B | MET685 | |
| D | MET685 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 10 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 |
| Chain | Residue | Details |
| A | GLN350 | |
| C | SER769 | |
| A | ASP440 | |
| A | ASP469 | |
| A | ASN489 | |
| A | SER769 | |
| C | GLN350 | |
| C | ASP440 | |
| C | ASP469 | |
| C | ASN489 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21677647, ECO:0007744|PDB:3QEK, ECO:0007744|PDB:3QEL, ECO:0007744|PDB:3QEM |
| Chain | Residue | Details |
| A | ASP368 | |
| C | ASP368 |
