5INM
Mouse Tdp2 protein, apo state with variable DNA-binding grasp conformations
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 401 |
| Chain | Residue |
| A | ASP132 |
| A | GLU162 |
| A | HOH501 |
| A | HOH514 |
| A | HOH536 |
| A | HOH539 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 402 |
| Chain | Residue |
| A | GLU246 |
| A | ARG249 |
| A | THR253 |
| A | PHE209 |
| A | PRO210 |
| A | ASN211 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 401 |
| Chain | Residue |
| B | ASP132 |
| B | GLU162 |
| B | HOH506 |
| B | HOH525 |
| B | HOH528 |
| B | HOH529 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 401 |
| Chain | Residue |
| C | ARG241 |
| C | ARG276 |
| C | HIS323 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 D 401 |
| Chain | Residue |
| D | ARG276 |
| D | ASP277 |
| D | GLN278 |
| D | ARG327 |
| D | HOH505 |
| D | HOH525 |
| D | HOH535 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue MG D 402 |
| Chain | Residue |
| D | ASP132 |
| D | GLU162 |
| D | HOH502 |
| D | HOH504 |
| D | HOH513 |
| D | HOH554 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 E 401 |
| Chain | Residue |
| E | ARG276 |
| E | ASP277 |
| E | GLN278 |
| E | ARG327 |
| E | HOH515 |
| E | HOH538 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue MG E 402 |
| Chain | Residue |
| E | ASP132 |
| E | GLU162 |
| E | HOH501 |
| E | HOH513 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:23104055, ECO:0000305|PubMed:27060144 |
| Chain | Residue | Details |
| A | ASP272 | |
| B | ASP272 | |
| C | ASP272 | |
| D | ASP272 | |
| E | ASP272 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23104055, ECO:0000269|PubMed:27099339, ECO:0007744|PDB:4GYZ, ECO:0007744|PDB:4GZ2, ECO:0007744|PDB:5J42 |
| Chain | Residue | Details |
| C | ASP132 | |
| D | ASP132 | |
| E | ASP132 | |
| A | ASP132 | |
| B | ASP132 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23104055, ECO:0000269|PubMed:24808172, ECO:0000269|PubMed:27099339, ECO:0007744|PDB:4GYZ, ECO:0007744|PDB:4GZ1, ECO:0007744|PDB:4GZ2, ECO:0007744|PDB:4PUQ, ECO:0007744|PDB:5HT2, ECO:0007744|PDB:5INP, ECO:0007744|PDB:5J42 |
| Chain | Residue | Details |
| B | GLU162 | |
| C | GLU162 | |
| D | GLU162 | |
| E | GLU162 | |
| A | GLU162 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | SITE: Interaction with 5' end of substrate DNA => ECO:0000269|PubMed:23104055, ECO:0000269|PubMed:27060144 |
| Chain | Residue | Details |
| A | TYR188 | |
| B | TYR188 | |
| C | TYR188 | |
| D | TYR188 | |
| E | TYR188 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | SITE: Interaction with 5' end of substrate DNA => ECO:0000269|PubMed:23104055, ECO:0000269|PubMed:24808172, ECO:0000269|PubMed:27060144 |
| Chain | Residue | Details |
| A | TRP307 | |
| A | HIS359 | |
| B | TRP307 | |
| B | HIS359 | |
| C | TRP307 | |
| C | HIS359 | |
| D | TRP307 | |
| D | HIS359 | |
| E | TRP307 | |
| E | HIS359 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 5 |
| Details | SITE: Interaction with 5' end of substrate DNA => ECO:0000269|PubMed:23104055 |
| Chain | Residue | Details |
| A | PHE325 | |
| B | PHE325 | |
| C | PHE325 | |
| D | PHE325 | |
| E | PHE325 |
