5INI

Structural basis for acyl-CoA carboxylase-mediated assembly of unusual polyketide synthase extender units incorporated into the stambomycin antibiotics

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003989	molecular_function	acetyl-CoA carboxylase activity
A	0004658	molecular_function	propionyl-CoA carboxylase activity
A	0006633	biological_process	fatty acid biosynthetic process
A	0009317	cellular_component	acetyl-CoA carboxylase complex
A	0016740	molecular_function	transferase activity
A	0016874	molecular_function	ligase activity
B	0003989	molecular_function	acetyl-CoA carboxylase activity
B	0004658	molecular_function	propionyl-CoA carboxylase activity
B	0006633	biological_process	fatty acid biosynthetic process
B	0009317	cellular_component	acetyl-CoA carboxylase complex
B	0016740	molecular_function	transferase activity
B	0016874	molecular_function	ligase activity
C	0003989	molecular_function	acetyl-CoA carboxylase activity
C	0004658	molecular_function	propionyl-CoA carboxylase activity
C	0006633	biological_process	fatty acid biosynthetic process
C	0009317	cellular_component	acetyl-CoA carboxylase complex
C	0016740	molecular_function	transferase activity
C	0016874	molecular_function	ligase activity
D	0003989	molecular_function	acetyl-CoA carboxylase activity
D	0004658	molecular_function	propionyl-CoA carboxylase activity
D	0006633	biological_process	fatty acid biosynthetic process
D	0009317	cellular_component	acetyl-CoA carboxylase complex
D	0016740	molecular_function	transferase activity
D	0016874	molecular_function	ligase activity
E	0003989	molecular_function	acetyl-CoA carboxylase activity
E	0004658	molecular_function	propionyl-CoA carboxylase activity
E	0006633	biological_process	fatty acid biosynthetic process
E	0009317	cellular_component	acetyl-CoA carboxylase complex
E	0016740	molecular_function	transferase activity
E	0016874	molecular_function	ligase activity
F	0003989	molecular_function	acetyl-CoA carboxylase activity
F	0004658	molecular_function	propionyl-CoA carboxylase activity
F	0006633	biological_process	fatty acid biosynthetic process
F	0009317	cellular_component	acetyl-CoA carboxylase complex
F	0016740	molecular_function	transferase activity
F	0016874	molecular_function	ligase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	binding site for residue HXC A 601

Chain	Residue
A	GLY111
A	GLY161
A	ALA182
A	GLY183
A	GLY184
A	TYR187
A	SER188
A	LEU191
A	THR207
A	GLY208
D	PHE399
A	SER113
D	GLY419
D	GLY420
D	ALA423
D	ILE454
A	GLY143
A	GLY144
A	ALA145
A	ARG146
A	ILE147
A	GLN148
A	TYR157

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site_id	AC2
Number of Residues	23
Details	binding site for residue HXC B 601

Chain	Residue
B	LEU110
B	GLY111
B	SER113
B	GLY143
B	ALA145
B	ARG146
B	ILE147
B	GLN148
B	TYR157
B	ALA182
B	GLY183
B	GLY184
B	TYR187
B	SER188
B	GLU210
F	PHE399
F	GLY419
F	GLY420
F	PRO453
F	ILE454
F	LEU455
F	ARG457
F	ARG458

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site_id	AC3
Number of Residues	20
Details	binding site for residue HXC E 601

Chain	Residue
B	GLU280
C	GLY419
C	GLY420
C	ALA423
E	GLY111
E	GLY143
E	GLY144
E	ALA145
E	ARG146
E	ILE147
E	GLN148
E	TYR157
E	GLY161
E	ALA182
E	GLY183
E	GLY184
E	TYR187
E	THR207
E	GLY208
E	GLU210

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site_id	AC4
Number of Residues	17
Details	binding site for residue HXC F 601

Chain	Residue
B	PHE399
B	GLY420
B	ALA423
B	VAL445
F	GLY111
F	GLY143
F	ALA145
F	ARG146
F	ILE147
F	GLN148
F	ILE154
F	TYR157
F	ALA182
F	GLY183
F	GLY184
F	TYR187
F	SER188

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