5INB

RepoMan-PP1g (protein phosphatase 1, gamma isoform) holoenzyme complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000070	biological_process	mitotic sister chromatid segregation
A	0000165	biological_process	MAPK cascade
A	0000776	cellular_component	kinetochore
A	0000781	cellular_component	chromosome, telomeric region
A	0003723	molecular_function	RNA binding
A	0004721	molecular_function	phosphoprotein phosphatase activity
A	0004722	molecular_function	protein serine/threonine phosphatase activity
A	0005515	molecular_function	protein binding
A	0005521	molecular_function	lamin binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005815	cellular_component	microtubule organizing center
A	0005829	cellular_component	cytosol
A	0005925	cellular_component	focal adhesion
A	0005977	biological_process	glycogen metabolic process
A	0006470	biological_process	protein dephosphorylation
A	0008157	molecular_function	protein phosphatase 1 binding
A	0016607	cellular_component	nuclear speck
A	0016787	molecular_function	hydrolase activity
A	0016791	molecular_function	phosphatase activity
A	0019901	molecular_function	protein kinase binding
A	0019903	molecular_function	protein phosphatase binding
A	0019904	molecular_function	protein domain specific binding
A	0030182	biological_process	neuron differentiation
A	0030496	cellular_component	midbody
A	0032154	cellular_component	cleavage furrow
A	0032922	biological_process	circadian regulation of gene expression
A	0032991	cellular_component	protein-containing complex
A	0042752	biological_process	regulation of circadian rhythm
A	0043153	biological_process	entrainment of circadian clock by photoperiod
A	0043197	cellular_component	dendritic spine
A	0044877	molecular_function	protein-containing complex binding
A	0046579	biological_process	positive regulation of Ras protein signal transduction
A	0046872	molecular_function	metal ion binding
A	0048511	biological_process	rhythmic process
A	0051301	biological_process	cell division
A	0060252	biological_process	positive regulation of glial cell proliferation
A	0072357	cellular_component	PTW/PP1 phosphatase complex
A	0098793	cellular_component	presynapse
A	0098794	cellular_component	postsynapse
A	0098978	cellular_component	glutamatergic synapse

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue MLI A 401

Chain	Residue
A	ASP64
A	HOH538
A	HOH542
A	HOH614
A	HIS66
A	ASP92
A	GLU218
A	ASP220
A	ARG221
A	HIS248
A	TYR272
A	GOL402

---

site_id	AC2
Number of Residues	9
Details	binding site for residue GOL A 402

Chain	Residue
A	GLU218
A	ASN219
A	ASP220
A	GLN249
A	VAL250
A	MLI401
A	HOH513
A	HOH598
A	HOH630

---

site_id	AC3
Number of Residues	7
Details	binding site for residue GOL A 403

Chain	Residue
A	GLN185
A	ARG188
A	SER224
A	PHE225
A	HOH505
A	HOH516
A	HOH520

---

site_id	AC4
Number of Residues	8
Details	binding site for residue GOL A 404

Chain	Residue
A	CYS127
A	SER129
A	VAL195
A	PRO196
A	ASP197
A	CYS202
A	TRP206
A	HOH649

---

site_id	AC5
Number of Residues	9
Details	binding site for residue GOL A 405

Chain	Residue
A	PRO50
A	LEU53
A	GLU54
A	GLU116
A	PHE119
A	LYS141
A	HOH621
A	HOH653
A	HOH674

---

site_id	AC6
Number of Residues	8
Details	binding site for residue GOL A 406

Chain	Residue
A	PRO58
A	LEU59
A	LYS60
A	SER85
A	ASN86
A	SER284
A	VAL285
A	HOH528

---

site_id	AC7
Number of Residues	8
Details	binding site for residue GOL A 407

Chain	Residue
A	PRO209
A	GLN249
A	VAL251
A	GLU256
A	HOH515
A	HOH552
A	HOH577
A	HOH592

---

site_id	AC8
Number of Residues	4
Details	binding site for residue NA A 408

Chain	Residue
A	GLU54
A	ILE164
A	GLU167
A	HOH721

---

Functional Information from PROSITE/UniProt

site_id	PS00125
Number of Residues	6
Details	SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE

Chain	Residue	Details
A	LEU121-GLU126

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"7500362","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11535607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15280359","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35768504","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JK7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U32","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7SD0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Inhibition by microcystin toxin binding"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---