5IN8

Crystal structure of Q151H Aspergillus terreus aristolochene synthase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008299	biological_process	isoprenoid biosynthetic process
A	0010333	molecular_function	terpene synthase activity
A	0016829	molecular_function	lyase activity
A	0016838	molecular_function	carbon-oxygen lyase activity, acting on phosphates
A	0045483	molecular_function	aristolochene synthase activity
A	0046872	molecular_function	metal ion binding
B	0008299	biological_process	isoprenoid biosynthetic process
B	0010333	molecular_function	terpene synthase activity
B	0016829	molecular_function	lyase activity
B	0016838	molecular_function	carbon-oxygen lyase activity, acting on phosphates
B	0045483	molecular_function	aristolochene synthase activity
B	0046872	molecular_function	metal ion binding
C	0008299	biological_process	isoprenoid biosynthetic process
C	0010333	molecular_function	terpene synthase activity
C	0016829	molecular_function	lyase activity
C	0016838	molecular_function	carbon-oxygen lyase activity, acting on phosphates
C	0045483	molecular_function	aristolochene synthase activity
C	0046872	molecular_function	metal ion binding
D	0008299	biological_process	isoprenoid biosynthetic process
D	0010333	molecular_function	terpene synthase activity
D	0016829	molecular_function	lyase activity
D	0016838	molecular_function	carbon-oxygen lyase activity, acting on phosphates
D	0045483	molecular_function	aristolochene synthase activity
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue GOL A 401

Chain	Residue
A	ARG107
A	GLU142
A	ARG149
A	HOH551
A	HOH555
C	ARG197
C	GLU200
C	LEU275

---

site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 402

Chain	Residue
A	HOH599
A	HOH617
A	HOH664
A	HOH702
A	HOH709
A	HOH593

---

site_id	AC3
Number of Residues	6
Details	binding site for residue MG A 403

Chain	Residue
A	ASN213
A	SER217
A	GLU221
A	PO4404
A	HOH501
A	HOH609

---

site_id	AC4
Number of Residues	9
Details	binding site for residue PO4 A 404

Chain	Residue
A	ASN213
A	SER217
A	LYS220
A	GLU221
A	ARG308
A	TYR309
A	MG403
A	HOH609
A	HOH664

---

site_id	AC5
Number of Residues	3
Details	binding site for residue GOL A 405

Chain	Residue
A	GLY108
A	TYR123
A	GLU127

---

site_id	AC6
Number of Residues	16
Details	binding site for residue POP B 401

Chain	Residue
B	ARG169
B	ASN213
B	SER217
B	LYS220
B	GLU221
B	ARG308
B	TYR309
B	MG402
B	MG403
B	HOH502
B	HOH503
B	HOH504
B	HOH505
B	HOH507
B	HOH514
B	HOH639

---

site_id	AC7
Number of Residues	5
Details	binding site for residue MG B 402

Chain	Residue
B	ASN213
B	SER217
B	GLU221
B	POP401
B	HOH508

---

site_id	AC8
Number of Residues	6
Details	binding site for residue MG B 403

Chain	Residue
B	POP401
B	HOH503
B	HOH519
B	HOH607
B	HOH639
B	HOH654

---

site_id	AC9
Number of Residues	7
Details	binding site for residue GOL B 404

Chain	Residue
B	PRO10
B	GLU300
B	GLN304
B	HOH535
B	HOH584
C	ARG114
C	ASP124

---

site_id	AD1
Number of Residues	2
Details	binding site for residue GOL B 405

Chain	Residue
B	GLU9
C	GLU29

---

site_id	AD2
Number of Residues	7
Details	binding site for residue GOL C 401

Chain	Residue
A	ARG197
A	LEU275
A	HOH595
C	ARG107
C	GLU142
C	ARG149
C	HOH517

---

site_id	AD3
Number of Residues	6
Details	binding site for residue MG C 402

Chain	Residue
C	ASN213
C	SER217
C	GLU221
C	PO4404
C	HOH506
C	HOH507

---

site_id	AD4
Number of Residues	6
Details	binding site for residue MG C 403

Chain	Residue
C	HOH522
C	HOH557
C	HOH561
C	HOH615
C	HOH630
C	HOH634

---

site_id	AD5
Number of Residues	9
Details	binding site for residue PO4 C 404

Chain	Residue
C	PHE81
C	ASN213
C	LYS220
C	GLU221
C	ARG308
C	TYR309
C	MG402
C	HOH506
C	HOH522

---

site_id	AD6
Number of Residues	4
Details	binding site for residue GOL C 405

Chain	Residue
C	TYR120
B	PRO12
B	SER13
C	ARG114

---

site_id	AD7
Number of Residues	3
Details	binding site for residue GOL C 406

Chain	Residue
C	LEU35
C	GLU43
C	ARG46

---

site_id	AD8
Number of Residues	7
Details	binding site for residue MG D 401

Chain	Residue
D	ARG169
D	ASN213
D	SER217
D	GLU221
D	PO4403
D	HOH501
D	HOH505

---

site_id	AD9
Number of Residues	5
Details	binding site for residue MG D 402

Chain	Residue
D	HOH536
D	HOH552
D	HOH554
D	HOH565
D	HOH572

---

site_id	AE1
Number of Residues	12
Details	binding site for residue PO4 D 403

Chain	Residue
D	PHE81
D	ASN213
D	SER217
D	LYS220
D	GLU221
D	ARG308
D	TYR309
D	MG401
D	HOH501
D	HOH507
D	HOH508
D	HOH554

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17261032","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18385128","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17261032","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18385128","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3BNX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18385128","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3BNX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---