5ILN
Crystal structure of Aspartate Transcarbamoylase from Plasmodium falciparum (PfATC) with bound citrate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004070 | molecular_function | aspartate carbamoyltransferase activity |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0016597 | molecular_function | amino acid binding |
| A | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| B | 0004070 | molecular_function | aspartate carbamoyltransferase activity |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0016597 | molecular_function | amino acid binding |
| B | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| C | 0004070 | molecular_function | aspartate carbamoyltransferase activity |
| C | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| C | 0006520 | biological_process | amino acid metabolic process |
| C | 0016597 | molecular_function | amino acid binding |
| C | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 401 |
| Chain | Residue |
| A | ASN57 |
| A | SER59 |
| A | SER173 |
| A | LYS175 |
| A | PRO176 |
| A | HOH509 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 A 402 |
| Chain | Residue |
| A | THR110 |
| A | ARG159 |
| A | HOH515 |
| A | SER107 |
| A | THR108 |
| A | ARG109 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 B 402 |
| Chain | Residue |
| B | SER107 |
| B | THR108 |
| B | ARG109 |
| B | THR110 |
| B | ARG159 |
| B | HOH544 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | binding site for residue FLC C 401 |
| Chain | Residue |
| A | LYS138 |
| C | THR110 |
| C | ARG159 |
| C | HIS187 |
| C | GLN190 |
| C | GLY225 |
| C | ARG226 |
| C | THR227 |
| C | ARG295 |
| C | GLN297 |
| C | LEU334 |
| C | PRO335 |
| C | PO4404 |
| C | HOH501 |
| C | HOH535 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 402 |
| Chain | Residue |
| C | LYS223 |
| C | ASN224 |
| C | SER249 |
| C | ARG300 |
| C | GLU306 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue GOL C 403 |
| Chain | Residue |
| C | SER162 |
| C | LYS163 |
| C | LYS164 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 C 404 |
| Chain | Residue |
| A | SER135 |
| A | LYS138 |
| C | SER107 |
| C | THR108 |
| C | ARG109 |
| C | THR110 |
| C | ARG159 |
| C | LEU334 |
| C | FLC401 |
| C | HOH501 |
Functional Information from PROSITE/UniProt
| site_id | PS00097 |
| Number of Residues | 8 |
| Details | CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FlEpSTRT |
| Chain | Residue | Details |
| A | PHE103-THR110 |
| site_id | PS00181 |
| Number of Residues | 17 |
| Details | GLNA_ATP Glutamine synthetase putative ATP-binding region signature. KPIinag.NGTGeHptqS |
| Chain | Residue | Details |
| A | LYS175-SER191 |
