5IKK

Structure of the histone deacetylase Clr3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000118	cellular_component	histone deacetylase complex
A	0000183	biological_process	rDNA heterochromatin formation
A	0000775	cellular_component	chromosome, centromeric region
A	0000781	cellular_component	chromosome, telomeric region
A	0000785	cellular_component	chromatin
A	0000791	cellular_component	euchromatin
A	0004407	molecular_function	histone deacetylase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0005721	cellular_component	pericentric heterochromatin
A	0005730	cellular_component	nucleolus
A	0006325	biological_process	chromatin organization
A	0010468	biological_process	regulation of gene expression
A	0016787	molecular_function	hydrolase activity
A	0030466	biological_process	silent mating-type cassette heterochromatin formation
A	0031078	molecular_function	histone H3K14 deacetylase activity
A	0031508	biological_process	pericentric heterochromatin formation
A	0031509	biological_process	subtelomeric heterochromatin formation
A	0031934	cellular_component	mating-type region heterochromatin
A	0033553	cellular_component	rDNA heterochromatin
A	0040029	biological_process	epigenetic regulation of gene expression
A	0070824	cellular_component	SHREC complex
A	0090053	biological_process	positive regulation of pericentric heterochromatin formation
A	0140718	biological_process	facultative heterochromatin formation
A	0140720	cellular_component	subtelomeric heterochromatin
A	1990342	cellular_component	heterochromatin island

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 701

Chain	Residue
A	HIS195
A	ASP234
A	HIS236
A	ASP327

---

site_id	AC2
Number of Residues	6
Details	binding site for residue K A 702

Chain	Residue
A	HOH856
A	PHE245
A	ASP248
A	VAL251
A	ARG284
A	HOH822

---

site_id	AC3
Number of Residues	3
Details	binding site for residue ZN A 703

Chain	Residue
A	HIS68
A	HIS77
A	CYS162

---

site_id	AC4
Number of Residues	5
Details	binding site for residue K A 704

Chain	Residue
A	ASP232
A	ASP234
A	HIS236
A	SER255
A	LEU256

---

site_id	AC5
Number of Residues	6
Details	binding site for residue NO3 A 705

Chain	Residue
A	ARG64
A	MET65
A	ARG66
A	LYS452
A	ASN476
A	HOH808

---

site_id	AC6
Number of Residues	6
Details	binding site for residue NO3 A 706

Chain	Residue
A	TYR313
A	ASP316
A	HIS346
A	ARG390
A	LEU391
A	HOH967

---

site_id	AC7
Number of Residues	4
Details	binding site for residue NO3 A 707

Chain	Residue
A	SER412
A	GLN413
A	TYR414
A	ARG419

---

site_id	AC8
Number of Residues	3
Details	binding site for residue EDO A 708

Chain	Residue
A	TYR302
A	ARG416
A	ARG419

---

site_id	AC9
Number of Residues	8
Details	binding site for residue EDO A 709

Chain	Residue
A	ARG440
A	HIS488
A	ASP513
A	VAL515
A	SER516
A	ASP531
A	HOH925
A	HOH954

---

site_id	AD1
Number of Residues	4
Details	binding site for residue EDO A 710

Chain	Residue
A	ASP80
A	GLY366
A	TYR367
A	LEU369

---

site_id	AD2
Number of Residues	6
Details	binding site for residue SO4 A 711

Chain	Residue
A	TYR129
A	GLU617
A	PRO621
A	LYS646
A	ARG647
A	ARG648

---

site_id	AD3
Number of Residues	5
Details	binding site for residue MG A 712

Chain	Residue
A	PRO427
A	ASP429
A	VAL432
A	HOH906
A	HOH934

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000250

Chain	Residue	Details
A	HIS195

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