5IID
Crystal Structure of the fifth bromodomain of human polybromo (PB1) in complex with 2-(3,4-dihydroxyphenyl)-5-hydroxy-4H-chromen-4-one
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue 6BK A 801 |
| Chain | Residue |
| A | ILE683 |
| B | LEU744 |
| A | LEU687 |
| A | PRO688 |
| A | TYR696 |
| A | MET704 |
| A | ALA735 |
| A | ASN739 |
| A | ILE745 |
| A | HOH901 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue 6BK B 801 |
| Chain | Residue |
| A | LEU744 |
| B | ILE683 |
| B | PHE684 |
| B | TYR696 |
| B | MET704 |
| B | MET731 |
| B | ALA735 |
| B | ASN739 |
| B | ILE745 |
| B | HOH903 |
| B | HOH909 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 58 |
| Details | BROMODOMAIN_1 Bromodomain signature. SaiFlrlpSrselp..DYYltIkkpMdmekIrshmmank..Yqdidsmvedfvm.MfnNActY |
| Chain | Residue | Details |
| A | SER681-TYR738 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 220 |
| Details | Domain: {"description":"Bromo 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
