5IH4

Human Casein Kinase 1 isoform delta apo (kinase domain)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 301

Chain	Residue
A	HIS50
A	CYS71
A	HIS278
A	SRT302

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site_id	AC2
Number of Residues	12
Details	binding site for residue SRT A 302

Chain	Residue
A	ARG279
A	ZN301
A	HOH475
A	HOH508
A	HOH524
A	HOH547
A	HOH552
A	HIS50
A	LYS57
A	CYS71
A	ARG259
A	HIS278

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site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 A 303

Chain	Residue
A	ARG127
A	LYS154
A	LYS171
A	GLU189

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site_id	AC4
Number of Residues	6
Details	binding site for residue SO4 A 304

Chain	Residue
A	ARG178
A	GLN214
A	GLY215
A	LYS224
A	HOH421
A	HOH541

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGSFGDIYlGtdiaagee..........VAIK

Chain	Residue	Details
A	ILE15-LYS38

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site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. FiHrDVKpdNFLM

Chain	Residue	Details
A	PHE124-MET136

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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