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5IF4

Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) inhibitors using Structure-Based Design

Functional Information from GO Data
ChainGOidnamespacecontents
A0042981biological_processregulation of apoptotic process
B0042981biological_processregulation of apoptotic process
Functional Information from PDB Data
site_idAC1
Number of Residues16
Detailsbinding site for residue 6AK A 400
ChainResidue
AHIS224
ALEU267
APHE270
AGLY271
AILE294
AHOH540
AHOH549
BHIS252
AALA227
APHE228
AMET231
AVAL249
AMET250
AVAL253
AASN260
AARG263

site_idAC2
Number of Residues16
Detailsbinding site for residue 6AK B 400
ChainResidue
BHIS224
BALA227
BPHE228
BMET231
BMET250
BVAL253
BPHE254
BASP256
BGLY257
BVAL258
BASN260
BARG263
BTHR266
BLEU267
BPHE270
BGLY271

Functional Information from PROSITE/UniProt
site_idPS01080
Number of Residues20
DetailsBH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. VFsDGvtNWGRIVTLIsFGA
ChainResidueDetails
AVAL253-ALA272

site_idPS01258
Number of Residues12
DetailsBH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WLvkqRGWDgFV
ChainResidueDetails
ATRP305-VAL316

site_idPS01259
Number of Residues15
DetailsBH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. AletLRrVGDGVQRN
ChainResidueDetails
AALA209-ASN223

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
ChainResidueDetails
ALYS194
ALYS197
BLYS194
BLYS197

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PDB entries from 2024-07-17

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