5ICE

Crystal structure of (S)-norcoclaurine 6-O-methyltransferase with S-adenosyl-L-homocysteine and norlaudanosoline

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008168	molecular_function	methyltransferase activity
A	0008171	molecular_function	O-methyltransferase activity
A	0009820	biological_process	alkaloid metabolic process
A	0016740	molecular_function	transferase activity
A	0030786	molecular_function	(RS)-norcoclaurine 6-O-methyltransferase activity
A	0032259	biological_process	methylation
A	0046983	molecular_function	protein dimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	binding site for residue SAH A 401

Chain	Residue
A	MET166
A	CYS253
A	ILE254
A	ASP257
A	TRP258
A	2H4402
A	HOH545
A	HOH570
A	HOH605
A	HOH616
A	HOH620
A	THR170
A	HOH629
A	HOH652
A	GLY195
A	ASP218
A	LEU219
A	VAL222
A	ASP238
A	MET239
A	LYS252

---

site_id	AC2
Number of Residues	19
Details	binding site for residue 2H4 A 402

Chain	Residue
A	TRP16
A	TYR20
A	ALA110
A	ILE114
A	ILE148
A	PHE162
A	GLY165
A	MET166
A	ASP169
A	CYS253
A	HIS256
A	ASP257
A	ASP306
A	MET307
A	ASN310
A	SAH401
A	HOH509
A	HOH642
A	HOH740

---

site_id	AC3
Number of Residues	4
Details	binding site for residue K A 403

Chain	Residue
A	HIS124
A	HIS124
A	HOH604
A	HOH604

---

site_id	AC4
Number of Residues	3
Details	binding site for residue K A 404

Chain	Residue
A	ASP289
A	THR297
A	ARG300

---

site_id	AC5
Number of Residues	4
Details	binding site for residue K A 405

Chain	Residue
A	ASN8
A	HIS155
A	PRO156
A	GLU157

---

site_id	AC6
Number of Residues	6
Details	binding site for residue EDO A 406

Chain	Residue
A	MET3
A	GLU7
A	TRP103
A	ASP104
A	LYS105
A	HOH581

---

site_id	AC7
Number of Residues	7
Details	binding site for residue EDO A 407

Chain	Residue
A	ASN17
A	ASN17
A	GLY21
A	ASP24
A	ASP24
A	HOH650
A	HOH650

---

site_id	AC8
Number of Residues	4
Details	binding site for residue EDO A 408

Chain	Residue
A	LYS29
A	LEU112
A	THR115
A	ASP116

---

site_id	AC9
Number of Residues	4
Details	binding site for residue EDO A 409

Chain	Residue
A	ILE40
A	GLY44
A	GLY91
A	LEU92

---

site_id	AD1
Number of Residues	3
Details	binding site for residue EDO A 410

Chain	Residue
A	PRO220
A	HIS221
A	HOH503

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01020","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27232113","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ICC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ICE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ICF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27232113","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ICE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01020","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27232113","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ICC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ICE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ICF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---