5ICC

Crystal structure of (S)-norcoclaurine 6-O-methyltransferase with S-adenosyl-L-homocysteine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008168	molecular_function	methyltransferase activity
A	0008171	molecular_function	O-methyltransferase activity
A	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
A	0009820	biological_process	alkaloid metabolic process
A	0030786	molecular_function	(RS)-norcoclaurine 6-O-methyltransferase activity
A	0032259	biological_process	methylation
A	0046983	molecular_function	protein dimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	binding site for residue SAH A 401

Chain	Residue
A	TRP149
A	MET239
A	LYS252
A	CYS253
A	ILE254
A	ASP257
A	EDO414
A	HOH543
A	HOH550
A	HOH567
A	HOH615
A	MET166
A	HOH623
A	HOH631
A	HOH634
A	THR170
A	GLY195
A	ASP218
A	LEU219
A	VAL222
A	GLY237
A	ASP238

---

site_id	AC2
Number of Residues	4
Details	binding site for residue K A 402

Chain	Residue
A	HIS124
A	HIS124
A	HOH626
A	HOH626

---

site_id	AC3
Number of Residues	4
Details	binding site for residue K A 403

Chain	Residue
A	ASN8
A	HIS155
A	PRO156
A	GLU157

---

site_id	AC4
Number of Residues	4
Details	binding site for residue NA A 404

Chain	Residue
A	TYR67
A	TYR90
A	HOH574
A	HOH605

---

site_id	AC5
Number of Residues	3
Details	binding site for residue NA A 405

Chain	Residue
A	ASP289
A	THR297
A	ARG300

---

site_id	AC6
Number of Residues	6
Details	binding site for residue EDO A 406

Chain	Residue
A	LYS14
A	ASN17
A	PHE18
A	HOH515
A	HOH568
A	HOH642

---

site_id	AC7
Number of Residues	3
Details	binding site for residue EDO A 407

Chain	Residue
A	PRO220
A	HIS221
A	HOH610

---

site_id	AC8
Number of Residues	3
Details	binding site for residue EDO A 408

Chain	Residue
A	ARG269
A	ASP272
A	HOH502

---

site_id	AC9
Number of Residues	5
Details	binding site for residue EDO A 409

Chain	Residue
A	THR317
A	GLU318
A	GLU319
A	HOH520
A	HOH548

---

site_id	AD1
Number of Residues	11
Details	binding site for residue EDO A 410

Chain	Residue
A	LEU9
A	GLU154
A	TYR296
A	ARG300
A	HIS337
A	SER339
A	ALA340
A	SER343
A	HOH505
A	HOH519
A	HOH599

---

site_id	AD2
Number of Residues	5
Details	binding site for residue EDO A 411

Chain	Residue
A	LYS29
A	LEU112
A	THR115
A	ASP116
A	HOH603

---

site_id	AD3
Number of Residues	5
Details	binding site for residue EDO A 412

Chain	Residue
A	ILE40
A	GLY44
A	SER45
A	GLY91
A	LEU92

---

site_id	AD4
Number of Residues	1
Details	binding site for residue EDO A 413

Chain	Residue
A	LYS101

---

site_id	AD5
Number of Residues	3
Details	binding site for residue EDO A 414

Chain	Residue
A	ASP238
A	SAH401
A	HOH570

---

site_id	AD6
Number of Residues	4
Details	binding site for residue EDO A 415

Chain	Residue
A	TYR67
A	LYS81
A	LEU88
A	HOH605

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU01020

Chain	Residue	Details
A	HIS256

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:27232113, ECO:0007744|PDB:5ICC, ECO:0007744|PDB:5ICE, ECO:0007744|PDB:5ICF

Chain	Residue	Details
A	MET166
A	THR170
A	GLY195
A	ASP238
A	LYS252

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:27232113, ECO:0007744|PDB:5ICE

Chain	Residue	Details
A	ASP169
A	CYS253
A	ASP306

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01020, ECO:0000269|PubMed:27232113, ECO:0007744|PDB:5ICC, ECO:0007744|PDB:5ICE, ECO:0007744|PDB:5ICF

Chain	Residue	Details
A	ASP218

---