5IBX

1.65 Angstrom Crystal Structure of Triosephosphate Isomerase (TIM) from Streptococcus pneumoniae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004807	molecular_function	triose-phosphate isomerase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006094	biological_process	gluconeogenesis
A	0006096	biological_process	glycolytic process
A	0016853	molecular_function	isomerase activity
A	0019563	biological_process	glycerol catabolic process
A	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
B	0004807	molecular_function	triose-phosphate isomerase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006094	biological_process	gluconeogenesis
B	0006096	biological_process	glycolytic process
B	0016853	molecular_function	isomerase activity
B	0019563	biological_process	glycerol catabolic process
B	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
C	0004807	molecular_function	triose-phosphate isomerase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006094	biological_process	gluconeogenesis
C	0006096	biological_process	glycolytic process
C	0016853	molecular_function	isomerase activity
C	0019563	biological_process	glycerol catabolic process
C	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
D	0004807	molecular_function	triose-phosphate isomerase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006094	biological_process	gluconeogenesis
D	0006096	biological_process	glycolytic process
D	0016853	molecular_function	isomerase activity
D	0019563	biological_process	glycerol catabolic process
D	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
E	0004807	molecular_function	triose-phosphate isomerase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006094	biological_process	gluconeogenesis
E	0006096	biological_process	glycolytic process
E	0016853	molecular_function	isomerase activity
E	0019563	biological_process	glycerol catabolic process
E	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
F	0004807	molecular_function	triose-phosphate isomerase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006094	biological_process	gluconeogenesis
F	0006096	biological_process	glycolytic process
F	0016853	molecular_function	isomerase activity
F	0019563	biological_process	glycerol catabolic process
F	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
G	0004807	molecular_function	triose-phosphate isomerase activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006094	biological_process	gluconeogenesis
G	0006096	biological_process	glycolytic process
G	0016853	molecular_function	isomerase activity
G	0019563	biological_process	glycerol catabolic process
G	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
H	0004807	molecular_function	triose-phosphate isomerase activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006094	biological_process	gluconeogenesis
H	0006096	biological_process	glycolytic process
H	0016853	molecular_function	isomerase activity
H	0019563	biological_process	glycerol catabolic process
H	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue NA A 301

Chain	Residue
A	MET224
A	CME226
A	VAL229
A	HOH453
A	HOH606
A	HOH618

---

site_id	AC2
Number of Residues	6
Details	binding site for residue NA B 301

Chain	Residue
B	HOH445
B	HOH637
B	HOH645
B	MET224
B	CME226
B	VAL229

---

site_id	AC3
Number of Residues	6
Details	binding site for residue NA B 302

Chain	Residue
B	ASP198
B	HOH629
B	HOH659
C	HOH511
C	HOH577
C	HOH599

---

site_id	AC4
Number of Residues	6
Details	binding site for residue NA C 301

Chain	Residue
C	MET224
C	CYS226
C	VAL229
C	HOH509
C	HOH595
C	HOH619

---

site_id	AC5
Number of Residues	6
Details	binding site for residue NA C 302

Chain	Residue
C	GLY88
C	HOH469
C	HOH524
C	HOH652
C	HOH660
C	HOH684

---

site_id	AC6
Number of Residues	6
Details	binding site for residue NA C 303

Chain	Residue
C	ALA172
C	LYS177
C	HOH608
C	HOH615
E	ALA197
E	HOH415

---

site_id	AC7
Number of Residues	6
Details	binding site for residue NA C 304

Chain	Residue
C	HOH498
C	HOH540
C	HOH550
C	HOH622
C	HOH653
C	HOH718

---

site_id	AC8
Number of Residues	6
Details	binding site for residue NA D 301

Chain	Residue
D	MET224
D	CME226
D	VAL229
D	HOH496
D	HOH622
D	HOH624

---

site_id	AC9
Number of Residues	6
Details	binding site for residue NA E 301

Chain	Residue
E	MET224
E	CME226
E	VAL229
E	HOH434
E	HOH616
E	HOH618

---

site_id	AD1
Number of Residues	6
Details	binding site for residue NA F 301

Chain	Residue
F	MET224
F	CYS226
F	VAL229
F	HOH410
F	HOH618
F	HOH624

---

site_id	AD2
Number of Residues	6
Details	binding site for residue NA F 302

Chain	Residue
F	GLY88
F	HOH505
F	HOH575
F	HOH648
F	HOH649
F	HOH690

---

site_id	AD3
Number of Residues	5
Details	binding site for residue NA G 301

Chain	Residue
G	MET224
G	CYS226
G	VAL229
G	HOH439
G	HOH557

---

site_id	AD4
Number of Residues	6
Details	binding site for residue NA H 301

Chain	Residue
H	MET224
H	CME226
H	VAL229
H	HOH533
H	HOH594
H	HOH610

---

Functional Information from PROSITE/UniProt

site_id	PS00171
Number of Residues	11
Details	TIM_1 Triosephosphate isomerase active site. AYEPIWAIGTG

Chain	Residue	Details
A	ALA166-GLY176
C	ALA166-GLY176

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Electrophile","evidences":[{"source":"HAMAP-Rule","id":"MF_00147","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00147","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00147","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---