5IBX
1.65 Angstrom Crystal Structure of Triosephosphate Isomerase (TIM) from Streptococcus pneumoniae
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004807 | molecular_function | triose-phosphate isomerase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006094 | biological_process | gluconeogenesis |
| A | 0006096 | biological_process | glycolytic process |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0019563 | biological_process | glycerol catabolic process |
| A | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
| B | 0004807 | molecular_function | triose-phosphate isomerase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006094 | biological_process | gluconeogenesis |
| B | 0006096 | biological_process | glycolytic process |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0019563 | biological_process | glycerol catabolic process |
| B | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
| C | 0004807 | molecular_function | triose-phosphate isomerase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006094 | biological_process | gluconeogenesis |
| C | 0006096 | biological_process | glycolytic process |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0019563 | biological_process | glycerol catabolic process |
| C | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
| D | 0004807 | molecular_function | triose-phosphate isomerase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006094 | biological_process | gluconeogenesis |
| D | 0006096 | biological_process | glycolytic process |
| D | 0016853 | molecular_function | isomerase activity |
| D | 0019563 | biological_process | glycerol catabolic process |
| D | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
| E | 0004807 | molecular_function | triose-phosphate isomerase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0006094 | biological_process | gluconeogenesis |
| E | 0006096 | biological_process | glycolytic process |
| E | 0016853 | molecular_function | isomerase activity |
| E | 0019563 | biological_process | glycerol catabolic process |
| E | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
| F | 0004807 | molecular_function | triose-phosphate isomerase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0006094 | biological_process | gluconeogenesis |
| F | 0006096 | biological_process | glycolytic process |
| F | 0016853 | molecular_function | isomerase activity |
| F | 0019563 | biological_process | glycerol catabolic process |
| F | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
| G | 0004807 | molecular_function | triose-phosphate isomerase activity |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005829 | cellular_component | cytosol |
| G | 0006094 | biological_process | gluconeogenesis |
| G | 0006096 | biological_process | glycolytic process |
| G | 0016853 | molecular_function | isomerase activity |
| G | 0019563 | biological_process | glycerol catabolic process |
| G | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
| H | 0004807 | molecular_function | triose-phosphate isomerase activity |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005829 | cellular_component | cytosol |
| H | 0006094 | biological_process | gluconeogenesis |
| H | 0006096 | biological_process | glycolytic process |
| H | 0016853 | molecular_function | isomerase activity |
| H | 0019563 | biological_process | glycerol catabolic process |
| H | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 301 |
| Chain | Residue |
| A | MET224 |
| A | CME226 |
| A | VAL229 |
| A | HOH453 |
| A | HOH606 |
| A | HOH618 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue NA B 301 |
| Chain | Residue |
| B | HOH445 |
| B | HOH637 |
| B | HOH645 |
| B | MET224 |
| B | CME226 |
| B | VAL229 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue NA B 302 |
| Chain | Residue |
| B | ASP198 |
| B | HOH629 |
| B | HOH659 |
| C | HOH511 |
| C | HOH577 |
| C | HOH599 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue NA C 301 |
| Chain | Residue |
| C | MET224 |
| C | CYS226 |
| C | VAL229 |
| C | HOH509 |
| C | HOH595 |
| C | HOH619 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue NA C 302 |
| Chain | Residue |
| C | GLY88 |
| C | HOH469 |
| C | HOH524 |
| C | HOH652 |
| C | HOH660 |
| C | HOH684 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue NA C 303 |
| Chain | Residue |
| C | ALA172 |
| C | LYS177 |
| C | HOH608 |
| C | HOH615 |
| E | ALA197 |
| E | HOH415 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue NA C 304 |
| Chain | Residue |
| C | HOH498 |
| C | HOH540 |
| C | HOH550 |
| C | HOH622 |
| C | HOH653 |
| C | HOH718 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue NA D 301 |
| Chain | Residue |
| D | MET224 |
| D | CME226 |
| D | VAL229 |
| D | HOH496 |
| D | HOH622 |
| D | HOH624 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue NA E 301 |
| Chain | Residue |
| E | MET224 |
| E | CME226 |
| E | VAL229 |
| E | HOH434 |
| E | HOH616 |
| E | HOH618 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue NA F 301 |
| Chain | Residue |
| F | MET224 |
| F | CYS226 |
| F | VAL229 |
| F | HOH410 |
| F | HOH618 |
| F | HOH624 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue NA F 302 |
| Chain | Residue |
| F | GLY88 |
| F | HOH505 |
| F | HOH575 |
| F | HOH648 |
| F | HOH649 |
| F | HOH690 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue NA G 301 |
| Chain | Residue |
| G | MET224 |
| G | CYS226 |
| G | VAL229 |
| G | HOH439 |
| G | HOH557 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue NA H 301 |
| Chain | Residue |
| H | MET224 |
| H | CME226 |
| H | VAL229 |
| H | HOH533 |
| H | HOH594 |
| H | HOH610 |
Functional Information from PROSITE/UniProt
| site_id | PS00171 |
| Number of Residues | 11 |
| Details | TIM_1 Triosephosphate isomerase active site. AYEPIWAIGTG |
| Chain | Residue | Details |
| A | ALA166-GLY176 | |
| C | ALA166-GLY176 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Active site: {"description":"Electrophile","evidences":[{"source":"HAMAP-Rule","id":"MF_00147","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00147","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00147","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
