5I9M
Crystal structure of B. pseudomallei FabI in complex with NAD and PT408
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| C | 0006629 | biological_process | lipid metabolic process |
| C | 0006631 | biological_process | fatty acid metabolic process |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 29 |
| Details | binding site for residue NAD A 301 |
| Chain | Residue |
| A | GLY13 |
| A | ILE92 |
| A | GLY93 |
| A | ILE119 |
| A | LEU144 |
| A | SER145 |
| A | LYS163 |
| A | ALA189 |
| A | GLY190 |
| A | PRO191 |
| A | ILE192 |
| A | LEU15 |
| A | THR194 |
| A | LEU195 |
| A | ALA196 |
| A | 69K302 |
| A | HOH426 |
| A | HOH446 |
| A | HOH457 |
| A | HOH465 |
| A | HOH468 |
| A | HOH485 |
| A | SER19 |
| A | ILE20 |
| A | VAL40 |
| A | CYS63 |
| A | ASP64 |
| A | VAL65 |
| A | SER91 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue 69K A 302 |
| Chain | Residue |
| A | GLY93 |
| A | ILE100 |
| A | TYR156 |
| A | LYS163 |
| A | ALA196 |
| A | ALA197 |
| A | PHE203 |
| A | NAD301 |
| site_id | AC3 |
| Number of Residues | 26 |
| Details | binding site for residue NAD B 301 |
| Chain | Residue |
| B | GLY13 |
| B | LEU15 |
| B | SER19 |
| B | ILE20 |
| B | VAL40 |
| B | CYS63 |
| B | ASP64 |
| B | VAL65 |
| B | SER91 |
| B | ILE92 |
| B | GLY93 |
| B | ILE119 |
| B | LEU144 |
| B | SER145 |
| B | TYR146 |
| B | LYS163 |
| B | PRO191 |
| B | ILE192 |
| B | THR194 |
| B | ALA196 |
| B | 69K302 |
| B | HOH411 |
| B | HOH413 |
| B | HOH415 |
| B | HOH439 |
| B | HOH446 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue 69K B 302 |
| Chain | Residue |
| B | GLY93 |
| B | PHE94 |
| B | ALA95 |
| B | TYR156 |
| B | LYS163 |
| B | ALA196 |
| B | ALA197 |
| B | PHE203 |
| B | NAD301 |
| site_id | AC5 |
| Number of Residues | 27 |
| Details | binding site for residue NAD C 301 |
| Chain | Residue |
| C | GLY13 |
| C | LEU15 |
| C | SER19 |
| C | ILE20 |
| C | VAL40 |
| C | CYS63 |
| C | ASP64 |
| C | VAL65 |
| C | SER91 |
| C | ILE92 |
| C | GLY93 |
| C | ILE119 |
| C | LEU144 |
| C | SER145 |
| C | TYR146 |
| C | LYS163 |
| C | ALA189 |
| C | PRO191 |
| C | ILE192 |
| C | THR194 |
| C | ALA196 |
| C | 69K302 |
| C | HOH406 |
| C | HOH417 |
| C | HOH438 |
| C | HOH452 |
| C | HOH476 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue 69K C 302 |
| Chain | Residue |
| C | GLY93 |
| C | TYR146 |
| C | TYR156 |
| C | LYS163 |
| C | ALA196 |
| C | ALA197 |
| C | PHE203 |
| C | NAD301 |
