Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5I8U

Crystal Structure of the RV1700 (MT ADPRASE) E142Q mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0006260	biological_process	DNA replication
A	0006281	biological_process	DNA repair
A	0006753	biological_process	nucleoside phosphate metabolic process
A	0006974	biological_process	DNA damage response
A	0016787	molecular_function	hydrolase activity
A	0019693	biological_process	ribose phosphate metabolic process
A	0044715	molecular_function	8-oxo-dGDP phosphatase activity
A	0044716	molecular_function	8-oxo-GDP phosphatase activity
A	0046872	molecular_function	metal ion binding
A	0047631	molecular_function	ADP-ribose diphosphatase activity
B	0005829	cellular_component	cytosol
B	0006260	biological_process	DNA replication
B	0006281	biological_process	DNA repair
B	0006753	biological_process	nucleoside phosphate metabolic process
B	0006974	biological_process	DNA damage response
B	0016787	molecular_function	hydrolase activity
B	0019693	biological_process	ribose phosphate metabolic process
B	0044715	molecular_function	8-oxo-dGDP phosphatase activity
B	0044716	molecular_function	8-oxo-GDP phosphatase activity
B	0046872	molecular_function	metal ion binding
B	0047631	molecular_function	ADP-ribose diphosphatase activity
C	0005829	cellular_component	cytosol
C	0006260	biological_process	DNA replication
C	0006281	biological_process	DNA repair
C	0006753	biological_process	nucleoside phosphate metabolic process
C	0006974	biological_process	DNA damage response
C	0016787	molecular_function	hydrolase activity
C	0019693	biological_process	ribose phosphate metabolic process
C	0044715	molecular_function	8-oxo-dGDP phosphatase activity
C	0044716	molecular_function	8-oxo-GDP phosphatase activity
C	0046872	molecular_function	metal ion binding
C	0047631	molecular_function	ADP-ribose diphosphatase activity
D	0005829	cellular_component	cytosol
D	0006260	biological_process	DNA replication
D	0006281	biological_process	DNA repair
D	0006753	biological_process	nucleoside phosphate metabolic process
D	0006974	biological_process	DNA damage response
D	0016787	molecular_function	hydrolase activity
D	0019693	biological_process	ribose phosphate metabolic process
D	0044715	molecular_function	8-oxo-dGDP phosphatase activity
D	0044716	molecular_function	8-oxo-GDP phosphatase activity
D	0046872	molecular_function	metal ion binding
D	0047631	molecular_function	ADP-ribose diphosphatase activity
E	0005829	cellular_component	cytosol
E	0006260	biological_process	DNA replication
E	0006281	biological_process	DNA repair
E	0006753	biological_process	nucleoside phosphate metabolic process
E	0006974	biological_process	DNA damage response
E	0016787	molecular_function	hydrolase activity
E	0019693	biological_process	ribose phosphate metabolic process
E	0044715	molecular_function	8-oxo-dGDP phosphatase activity
E	0044716	molecular_function	8-oxo-GDP phosphatase activity
E	0046872	molecular_function	metal ion binding
E	0047631	molecular_function	ADP-ribose diphosphatase activity
F	0005829	cellular_component	cytosol
F	0006260	biological_process	DNA replication
F	0006281	biological_process	DNA repair
F	0006753	biological_process	nucleoside phosphate metabolic process
F	0006974	biological_process	DNA damage response
F	0016787	molecular_function	hydrolase activity
F	0019693	biological_process	ribose phosphate metabolic process
F	0044715	molecular_function	8-oxo-dGDP phosphatase activity
F	0044716	molecular_function	8-oxo-GDP phosphatase activity
F	0046872	molecular_function	metal ion binding
F	0047631	molecular_function	ADP-ribose diphosphatase activity
G	0005829	cellular_component	cytosol
G	0006260	biological_process	DNA replication
G	0006281	biological_process	DNA repair
G	0006753	biological_process	nucleoside phosphate metabolic process
G	0006974	biological_process	DNA damage response
G	0016787	molecular_function	hydrolase activity
G	0019693	biological_process	ribose phosphate metabolic process
G	0044715	molecular_function	8-oxo-dGDP phosphatase activity
G	0044716	molecular_function	8-oxo-GDP phosphatase activity
G	0046872	molecular_function	metal ion binding
G	0047631	molecular_function	ADP-ribose diphosphatase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue SO4 G 301

Chain	Residue
G	THR66
G	ARG196
G	THR198
G	HOH409
G	HOH418
G	HOH425
G	HOH434
G	HOH494

site_id	AC2
Number of Residues	2
Details	binding site for residue FMT A 401

Chain	Residue
A	ALA76
A	ARG64

site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 A 402

Chain	Residue
A	ARG196
A	THR198
A	HOH510

site_id	AC4
Number of Residues	8
Details	binding site for residue PEG A 403

Chain	Residue
A	MET51
A	ASP52
A	ASP53
A	THR128
A	GLY129
A	LEU130
A	HOH502
C	HIS87

site_id	AC5
Number of Residues	6
Details	binding site for residue FMT C 401

Chain	Residue
C	ALA76
C	GLU93
C	GLU97
C	GLN142
C	NA402
C	HOH509

site_id	AC6
Number of Residues	4
Details	binding site for residue NA C 402

Chain	Residue
C	GLU93
C	GLU96
C	FMT401
C	HOH509

site_id	AC7
Number of Residues	3
Details	binding site for residue NA C 403

Chain	Residue
C	GLY44
C	PRO197
C	HOH525

site_id	AC8
Number of Residues	2
Details	binding site for residue SO4 D 301

Chain	Residue
D	THR66
D	TYR67

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	262
Details	Domain: {"description":"Nudix hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	154
Details	Motif: {"description":"Nudix box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	5
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"12906832","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27683242","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	21
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q93K97","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	21
Details	Binding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"12906832","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	26
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12906832","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)