Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5I8U

Crystal Structure of the RV1700 (MT ADPRASE) E142Q mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0006260	biological_process	DNA replication
A	0006281	biological_process	DNA repair
A	0006753	biological_process	nucleoside phosphate metabolic process
A	0006974	biological_process	DNA damage response
A	0008768	molecular_function	UDP-sugar diphosphatase activity
A	0008893	molecular_function	guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
A	0016787	molecular_function	hydrolase activity
A	0019144	molecular_function	ADP-sugar diphosphatase activity
A	0019693	biological_process	ribose phosphate metabolic process
A	0034432	molecular_function	bis(5'-adenosyl)-pentaphosphatase activity
A	0044715	molecular_function	8-oxo-dGDP phosphatase activity
A	0044716	molecular_function	8-oxo-GDP phosphatase activity
A	0046872	molecular_function	metal ion binding
A	0047631	molecular_function	ADP-ribose diphosphatase activity
B	0005829	cellular_component	cytosol
B	0006260	biological_process	DNA replication
B	0006281	biological_process	DNA repair
B	0006753	biological_process	nucleoside phosphate metabolic process
B	0006974	biological_process	DNA damage response
B	0008768	molecular_function	UDP-sugar diphosphatase activity
B	0008893	molecular_function	guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
B	0016787	molecular_function	hydrolase activity
B	0019144	molecular_function	ADP-sugar diphosphatase activity
B	0019693	biological_process	ribose phosphate metabolic process
B	0034432	molecular_function	bis(5'-adenosyl)-pentaphosphatase activity
B	0044715	molecular_function	8-oxo-dGDP phosphatase activity
B	0044716	molecular_function	8-oxo-GDP phosphatase activity
B	0046872	molecular_function	metal ion binding
B	0047631	molecular_function	ADP-ribose diphosphatase activity
C	0005829	cellular_component	cytosol
C	0006260	biological_process	DNA replication
C	0006281	biological_process	DNA repair
C	0006753	biological_process	nucleoside phosphate metabolic process
C	0006974	biological_process	DNA damage response
C	0008768	molecular_function	UDP-sugar diphosphatase activity
C	0008893	molecular_function	guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
C	0016787	molecular_function	hydrolase activity
C	0019144	molecular_function	ADP-sugar diphosphatase activity
C	0019693	biological_process	ribose phosphate metabolic process
C	0034432	molecular_function	bis(5'-adenosyl)-pentaphosphatase activity
C	0044715	molecular_function	8-oxo-dGDP phosphatase activity
C	0044716	molecular_function	8-oxo-GDP phosphatase activity
C	0046872	molecular_function	metal ion binding
C	0047631	molecular_function	ADP-ribose diphosphatase activity
D	0005829	cellular_component	cytosol
D	0006260	biological_process	DNA replication
D	0006281	biological_process	DNA repair
D	0006753	biological_process	nucleoside phosphate metabolic process
D	0006974	biological_process	DNA damage response
D	0008768	molecular_function	UDP-sugar diphosphatase activity
D	0008893	molecular_function	guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
D	0016787	molecular_function	hydrolase activity
D	0019144	molecular_function	ADP-sugar diphosphatase activity
D	0019693	biological_process	ribose phosphate metabolic process
D	0034432	molecular_function	bis(5'-adenosyl)-pentaphosphatase activity
D	0044715	molecular_function	8-oxo-dGDP phosphatase activity
D	0044716	molecular_function	8-oxo-GDP phosphatase activity
D	0046872	molecular_function	metal ion binding
D	0047631	molecular_function	ADP-ribose diphosphatase activity
E	0005829	cellular_component	cytosol
E	0006260	biological_process	DNA replication
E	0006281	biological_process	DNA repair
E	0006753	biological_process	nucleoside phosphate metabolic process
E	0006974	biological_process	DNA damage response
E	0008768	molecular_function	UDP-sugar diphosphatase activity
E	0008893	molecular_function	guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
E	0016787	molecular_function	hydrolase activity
E	0019144	molecular_function	ADP-sugar diphosphatase activity
E	0019693	biological_process	ribose phosphate metabolic process
E	0034432	molecular_function	bis(5'-adenosyl)-pentaphosphatase activity
E	0044715	molecular_function	8-oxo-dGDP phosphatase activity
E	0044716	molecular_function	8-oxo-GDP phosphatase activity
E	0046872	molecular_function	metal ion binding
E	0047631	molecular_function	ADP-ribose diphosphatase activity
F	0005829	cellular_component	cytosol
F	0006260	biological_process	DNA replication
F	0006281	biological_process	DNA repair
F	0006753	biological_process	nucleoside phosphate metabolic process
F	0006974	biological_process	DNA damage response
F	0008768	molecular_function	UDP-sugar diphosphatase activity
F	0008893	molecular_function	guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
F	0016787	molecular_function	hydrolase activity
F	0019144	molecular_function	ADP-sugar diphosphatase activity
F	0019693	biological_process	ribose phosphate metabolic process
F	0034432	molecular_function	bis(5'-adenosyl)-pentaphosphatase activity
F	0044715	molecular_function	8-oxo-dGDP phosphatase activity
F	0044716	molecular_function	8-oxo-GDP phosphatase activity
F	0046872	molecular_function	metal ion binding
F	0047631	molecular_function	ADP-ribose diphosphatase activity
G	0005829	cellular_component	cytosol
G	0006260	biological_process	DNA replication
G	0006281	biological_process	DNA repair
G	0006753	biological_process	nucleoside phosphate metabolic process
G	0006974	biological_process	DNA damage response
G	0008768	molecular_function	UDP-sugar diphosphatase activity
G	0008893	molecular_function	guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
G	0016787	molecular_function	hydrolase activity
G	0019144	molecular_function	ADP-sugar diphosphatase activity
G	0019693	biological_process	ribose phosphate metabolic process
G	0034432	molecular_function	bis(5'-adenosyl)-pentaphosphatase activity
G	0044715	molecular_function	8-oxo-dGDP phosphatase activity
G	0044716	molecular_function	8-oxo-GDP phosphatase activity
G	0046872	molecular_function	metal ion binding
G	0047631	molecular_function	ADP-ribose diphosphatase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue SO4 G 301

Chain	Residue
G	THR66
G	ARG196
G	THR198
G	HOH409
G	HOH418
G	HOH425
G	HOH434
G	HOH494

site_id	AC2
Number of Residues	2
Details	binding site for residue FMT A 401

Chain	Residue
A	ALA76
A	ARG64

site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 A 402

Chain	Residue
A	ARG196
A	THR198
A	HOH510

site_id	AC4
Number of Residues	8
Details	binding site for residue PEG A 403

Chain	Residue
A	MET51
A	ASP52
A	ASP53
A	THR128
A	GLY129
A	LEU130
A	HOH502
C	HIS87

site_id	AC5
Number of Residues	6
Details	binding site for residue FMT C 401

Chain	Residue
C	ALA76
C	GLU93
C	GLU97
C	GLN142
C	NA402
C	HOH509

site_id	AC6
Number of Residues	4
Details	binding site for residue NA C 402

Chain	Residue
C	GLU93
C	GLU96
C	FMT401
C	HOH509

site_id	AC7
Number of Residues	3
Details	binding site for residue NA C 403

Chain	Residue
C	GLY44
C	PRO197
C	HOH525

site_id	AC8
Number of Residues	2
Details	binding site for residue SO4 D 301

Chain	Residue
D	THR66
D	TYR67

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	ACT_SITE: Proton acceptor => ECO:0000305\|PubMed:12906832, ECO:0000305\|PubMed:27683242

Chain	Residue	Details
G	GLN142
A	GLN142
B	GLN142
C	GLN142
D	GLN142
E	GLN142
F	GLN142

site_id	SWS_FT_FI2
Number of Residues	14
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q93K97

Chain	Residue	Details
G	ARG37
D	ALA114
E	ARG37
E	ALA114
F	ARG37
F	ALA114
G	ALA114
A	ARG37
A	ALA114
B	ARG37
B	ALA114
C	ARG37
C	ALA114
D	ARG37

site_id	SWS_FT_FI3
Number of Residues	21
Details	BINDING: in other chain => ECO:0000269\|PubMed:12906832

Chain	Residue	Details
G	ARG64
C	ARG64
C	LEU78
C	GLU120
D	ARG64
D	LEU78
D	GLU120
E	ARG64
E	LEU78
E	GLU120
F	ARG64
G	LEU78
F	LEU78
F	GLU120
G	GLU120
A	ARG64
A	LEU78
A	GLU120
B	ARG64
B	LEU78
B	GLU120

site_id	SWS_FT_FI4
Number of Residues	28
Details	BINDING: BINDING => ECO:0000269\|PubMed:12906832

Chain	Residue	Details
G	ALA76
B	GLU93
B	GLU97
B	GLN142
C	ALA76
C	GLU93
C	GLU97
C	GLN142
D	ALA76
D	GLU93
D	GLU97
G	GLU93
D	GLN142
E	ALA76
E	GLU93
E	GLU97
E	GLN142
F	ALA76
F	GLU93
F	GLU97
F	GLN142
G	GLU97
G	GLN142
A	ALA76
A	GLU93
A	GLU97
A	GLN142
B	ALA76

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)