5I8U
Crystal Structure of the RV1700 (MT ADPRASE) E142Q mutant
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005829 | cellular_component | cytosol |
| A | 0019693 | biological_process | ribose phosphate metabolic process |
| A | 0044715 | molecular_function | 8-oxo-dGDP phosphatase activity |
| A | 0044716 | molecular_function | 8-oxo-GDP phosphatase activity |
| A | 0047631 | molecular_function | ADP-ribose diphosphatase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0019693 | biological_process | ribose phosphate metabolic process |
| B | 0044715 | molecular_function | 8-oxo-dGDP phosphatase activity |
| B | 0044716 | molecular_function | 8-oxo-GDP phosphatase activity |
| B | 0047631 | molecular_function | ADP-ribose diphosphatase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0019693 | biological_process | ribose phosphate metabolic process |
| C | 0044715 | molecular_function | 8-oxo-dGDP phosphatase activity |
| C | 0044716 | molecular_function | 8-oxo-GDP phosphatase activity |
| C | 0047631 | molecular_function | ADP-ribose diphosphatase activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0019693 | biological_process | ribose phosphate metabolic process |
| D | 0044715 | molecular_function | 8-oxo-dGDP phosphatase activity |
| D | 0044716 | molecular_function | 8-oxo-GDP phosphatase activity |
| D | 0047631 | molecular_function | ADP-ribose diphosphatase activity |
| E | 0005829 | cellular_component | cytosol |
| E | 0019693 | biological_process | ribose phosphate metabolic process |
| E | 0044715 | molecular_function | 8-oxo-dGDP phosphatase activity |
| E | 0044716 | molecular_function | 8-oxo-GDP phosphatase activity |
| E | 0047631 | molecular_function | ADP-ribose diphosphatase activity |
| F | 0005829 | cellular_component | cytosol |
| F | 0019693 | biological_process | ribose phosphate metabolic process |
| F | 0044715 | molecular_function | 8-oxo-dGDP phosphatase activity |
| F | 0044716 | molecular_function | 8-oxo-GDP phosphatase activity |
| F | 0047631 | molecular_function | ADP-ribose diphosphatase activity |
| G | 0005829 | cellular_component | cytosol |
| G | 0019693 | biological_process | ribose phosphate metabolic process |
| G | 0044715 | molecular_function | 8-oxo-dGDP phosphatase activity |
| G | 0044716 | molecular_function | 8-oxo-GDP phosphatase activity |
| G | 0047631 | molecular_function | ADP-ribose diphosphatase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 G 301 |
| Chain | Residue |
| G | THR66 |
| G | ARG196 |
| G | THR198 |
| G | HOH409 |
| G | HOH418 |
| G | HOH425 |
| G | HOH434 |
| G | HOH494 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue FMT A 401 |
| Chain | Residue |
| A | ALA76 |
| A | ARG64 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 402 |
| Chain | Residue |
| A | ARG196 |
| A | THR198 |
| A | HOH510 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue PEG A 403 |
| Chain | Residue |
| A | MET51 |
| A | ASP52 |
| A | ASP53 |
| A | THR128 |
| A | GLY129 |
| A | LEU130 |
| A | HOH502 |
| C | HIS87 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue FMT C 401 |
| Chain | Residue |
| C | ALA76 |
| C | GLU93 |
| C | GLU97 |
| C | GLN142 |
| C | NA402 |
| C | HOH509 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue NA C 402 |
| Chain | Residue |
| C | GLU93 |
| C | GLU96 |
| C | FMT401 |
| C | HOH509 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue NA C 403 |
| Chain | Residue |
| C | GLY44 |
| C | PRO197 |
| C | HOH525 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 D 301 |
| Chain | Residue |
| D | THR66 |
| D | TYR67 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 262 |
| Details | Domain: {"description":"Nudix hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 154 |
| Details | Motif: {"description":"Nudix box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"12906832","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27683242","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 21 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q93K97","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 21 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"12906832","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 26 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12906832","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
