5I81
aSMase with zinc
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001778 | biological_process | plasma membrane repair |
| A | 0004767 | molecular_function | sphingomyelin phosphodiesterase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005764 | cellular_component | lysosome |
| A | 0005768 | cellular_component | endosome |
| A | 0005811 | cellular_component | lipid droplet |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006684 | biological_process | sphingomyelin metabolic process |
| A | 0006685 | biological_process | sphingomyelin catabolic process |
| A | 0007165 | biological_process | signal transduction |
| A | 0007399 | biological_process | nervous system development |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0009615 | biological_process | response to virus |
| A | 0010212 | biological_process | response to ionizing radiation |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0023021 | biological_process | termination of signal transduction |
| A | 0034340 | biological_process | response to type I interferon |
| A | 0034480 | molecular_function | phosphatidylcholine phospholipase C activity |
| A | 0034612 | biological_process | response to tumor necrosis factor |
| A | 0034644 | biological_process | cellular response to UV |
| A | 0036019 | cellular_component | endolysosome |
| A | 0042060 | biological_process | wound healing |
| A | 0042220 | biological_process | response to cocaine |
| A | 0042599 | cellular_component | lamellar body |
| A | 0043065 | biological_process | positive regulation of apoptotic process |
| A | 0043202 | cellular_component | lysosomal lumen |
| A | 0043409 | biological_process | negative regulation of MAPK cascade |
| A | 0045807 | biological_process | positive regulation of endocytosis |
| A | 0046479 | biological_process | glycosphingolipid catabolic process |
| A | 0046513 | biological_process | ceramide biosynthetic process |
| A | 0046598 | biological_process | positive regulation of viral entry into host cell |
| A | 0046718 | biological_process | symbiont entry into host cell |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0061750 | molecular_function | acid sphingomyelin phosphodiesterase activity |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070555 | biological_process | response to interleukin-1 |
| A | 0071277 | biological_process | cellular response to calcium ion |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 84 |
| Details | Domain: {"description":"Saposin B-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00415","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27349982","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5I81","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I85","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I8R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JG8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Cleavage; by CASP7","evidences":[{"source":"PubMed","id":"21157428","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC/PRKCD","evidences":[{"source":"PubMed","id":"17303575","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00415","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27349982","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9030779","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5I81","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I85","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I8R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JG8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00415","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27349982","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9030779","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5I81","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I8R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JG8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"27349982","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5I81","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I85","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I8R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JG8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
