5I7V

Crystal structure of B. pseudomallei FabI in complex with NAD and PT02

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A	0006633	biological_process	fatty acid biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
B	0000166	molecular_function	nucleotide binding
B	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B	0006633	biological_process	fatty acid biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
C	0000166	molecular_function	nucleotide binding
C	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C	0006633	biological_process	fatty acid biosynthetic process
C	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	binding site for residue NAD A 301

Chain	Residue
A	GLY13
A	ILE92
A	GLY93
A	LEU144
A	SER145
A	LYS163
A	ALA189
A	GLY190
A	PRO191
A	ILE192
A	THR194
A	LEU15
A	ALA196
A	PV4302
A	HOH412
A	HOH422
A	SER19
A	ILE20
A	VAL40
A	CYS63
A	ASP64
A	VAL65
A	SER91

---

site_id	AC2
Number of Residues	8
Details	binding site for residue PV4 A 302

Chain	Residue
A	GLY93
A	PHE94
A	TYR146
A	TYR156
A	LYS163
A	ALA196
A	PHE203
A	NAD301

---

site_id	AC3
Number of Residues	23
Details	binding site for residue NAD B 301

Chain	Residue
B	GLY13
B	LEU15
B	SER19
B	ILE20
B	VAL40
B	CYS63
B	ASP64
B	VAL65
B	SER91
B	ILE92
B	GLY93
B	LEU144
B	SER145
B	LYS163
B	GLY190
B	PRO191
B	ILE192
B	THR194
B	LEU195
B	ALA196
B	PV4302
B	HOH405
B	HOH426

---

site_id	AC4
Number of Residues	7
Details	binding site for residue PV4 B 302

Chain	Residue
B	GLY93
B	PHE94
B	TYR156
B	MET159
B	LYS163
B	PHE203
B	NAD301

---

site_id	AC5
Number of Residues	28
Details	binding site for residue NAD C 301

Chain	Residue
C	GLY13
C	LEU14
C	LEU15
C	SER19
C	ILE20
C	VAL40
C	CYS63
C	ASP64
C	VAL65
C	SER91
C	ILE92
C	GLY93
C	PHE94
C	ILE119
C	LEU144
C	SER145
C	TYR146
C	LYS163
C	GLY190
C	PRO191
C	ILE192
C	THR194
C	LEU195
C	ALA196
C	PV4302
C	HOH405
C	HOH419
C	HOH431

---

site_id	AC6
Number of Residues	8
Details	binding site for residue PV4 C 302

Chain	Residue
C	GLY93
C	PHE94
C	TYR146
C	TYR156
C	MET159
C	ALA196
C	ALA197
C	NAD301

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