5I7H
Mycobacterium tuberculosis CysM in complex with the Urea-scaffold inhibitor 6 [3-(3-(4-Bromophenyl)ureido)benzoic acid]
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004124 | molecular_function | cysteine synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006535 | biological_process | cysteine biosynthetic process from serine |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0019344 | biological_process | cysteine biosynthetic process |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0033847 | molecular_function | O-phosphoserine sulfhydrylase activity |
| B | 0004124 | molecular_function | cysteine synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006535 | biological_process | cysteine biosynthetic process from serine |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0019344 | biological_process | cysteine biosynthetic process |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0033847 | molecular_function | O-phosphoserine sulfhydrylase activity |
| C | 0004124 | molecular_function | cysteine synthase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006535 | biological_process | cysteine biosynthetic process from serine |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| C | 0019344 | biological_process | cysteine biosynthetic process |
| C | 0030170 | molecular_function | pyridoxal phosphate binding |
| C | 0032991 | cellular_component | protein-containing complex |
| C | 0033847 | molecular_function | O-phosphoserine sulfhydrylase activity |
| D | 0004124 | molecular_function | cysteine synthase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006535 | biological_process | cysteine biosynthetic process from serine |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| D | 0019344 | biological_process | cysteine biosynthetic process |
| D | 0030170 | molecular_function | pyridoxal phosphate binding |
| D | 0032991 | cellular_component | protein-containing complex |
| D | 0033847 | molecular_function | O-phosphoserine sulfhydrylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue 68V A 401 |
| Chain | Residue |
| A | LYS51 |
| A | THR185 |
| A | ALA208 |
| A | GLU209 |
| A | PRO210 |
| A | SER265 |
| A | ALA268 |
| A | PLP402 |
| A | HOH526 |
| A | THR78 |
| A | SER79 |
| A | GLY80 |
| A | ASN81 |
| A | THR82 |
| A | GLN151 |
| A | TYR152 |
| A | GLY184 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue PLP A 402 |
| Chain | Residue |
| A | LYS51 |
| A | ASN81 |
| A | GLY182 |
| A | LEU183 |
| A | GLY184 |
| A | THR185 |
| A | THR186 |
| A | GLY187 |
| A | THR188 |
| A | SER265 |
| A | ALA294 |
| A | ASP295 |
| A | 68V401 |
| A | HOH516 |
| A | HOH524 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | binding site for residue 68V B 401 |
| Chain | Residue |
| B | LYS51 |
| B | THR78 |
| B | SER79 |
| B | GLY80 |
| B | ASN81 |
| B | THR82 |
| B | GLN151 |
| B | TYR152 |
| B | GLY184 |
| B | THR185 |
| B | ALA208 |
| B | GLU209 |
| B | PRO210 |
| B | SER265 |
| B | ALA268 |
| B | PLP402 |
| B | HOH520 |
| B | HOH537 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | binding site for residue 68V C 401 |
| Chain | Residue |
| C | LYS51 |
| C | THR78 |
| C | SER79 |
| C | GLY80 |
| C | ASN81 |
| C | THR82 |
| C | GLN151 |
| C | TYR152 |
| C | GLY184 |
| C | ALA208 |
| C | GLU209 |
| C | PRO210 |
| C | SER265 |
| C | ALA268 |
| C | PLP402 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | binding site for residue 68V D 401 |
| Chain | Residue |
| D | LYS51 |
| D | THR78 |
| D | SER79 |
| D | ASN81 |
| D | THR82 |
| D | GLN151 |
| D | TYR152 |
| D | GLY182 |
| D | GLY184 |
| D | ALA208 |
| D | GLU209 |
| D | PRO210 |
| D | ASN221 |
| D | SER265 |
| D | ALA268 |
| D | ALA323 |
| D | PLP403 |
| D | HOH502 |
| D | HOH508 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue CL D 402 |
| Chain | Residue |
| D | ARG220 |
| D | ASN221 |
| D | MET222 |
| site_id | AC7 |
| Number of Residues | 22 |
| Details | binding site for Di-peptide PLP B 402 and LYS B 51 |
| Chain | Residue |
| B | THR186 |
| B | GLY187 |
| B | THR188 |
| B | SER265 |
| B | ALA294 |
| B | ASP295 |
| B | 68V401 |
| B | HOH512 |
| B | HOH523 |
| B | HOH525 |
| B | SER49 |
| B | ILE50 |
| B | ASP52 |
| B | ARG53 |
| B | PRO54 |
| B | ALA55 |
| B | ASN81 |
| B | THR82 |
| B | SER85 |
| B | GLY182 |
| B | GLY184 |
| B | THR185 |
| site_id | AC8 |
| Number of Residues | 22 |
| Details | binding site for Di-peptide PLP C 402 and LYS C 51 |
| Chain | Residue |
| C | SER49 |
| C | ILE50 |
| C | ASP52 |
| C | ARG53 |
| C | PRO54 |
| C | ALA55 |
| C | ASN81 |
| C | THR82 |
| C | SER85 |
| C | GLY182 |
| C | GLY184 |
| C | THR185 |
| C | THR186 |
| C | GLY187 |
| C | THR188 |
| C | SER265 |
| C | ALA294 |
| C | ASP295 |
| C | 68V401 |
| C | HOH504 |
| C | HOH513 |
| C | HOH535 |
| site_id | AC9 |
| Number of Residues | 23 |
| Details | binding site for Di-peptide PLP D 403 and LYS D 51 |
| Chain | Residue |
| D | SER49 |
| D | ILE50 |
| D | ASP52 |
| D | ARG53 |
| D | PRO54 |
| D | ALA55 |
| D | ASN81 |
| D | THR82 |
| D | SER85 |
| D | GLY182 |
| D | LEU183 |
| D | GLY184 |
| D | THR185 |
| D | THR186 |
| D | GLY187 |
| D | THR188 |
| D | SER265 |
| D | ALA294 |
| D | ASP295 |
| D | 68V401 |
| D | HOH504 |
| D | HOH517 |
| D | HOH534 |
Functional Information from PROSITE/UniProt
| site_id | PS00901 |
| Number of Residues | 19 |
| Details | CYS_SYNTHASE Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. KlEdrn.PTgSIKdRpAvrM |
| Chain | Residue | Details |
| A | LYS40-MET58 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18771296, ECO:0000269|PubMed:18799456, ECO:0000269|PubMed:19101553 |
| Chain | Residue | Details |
| A | ASN81 | |
| A | SER265 | |
| B | ASN81 | |
| B | SER265 | |
| C | ASN81 | |
| C | SER265 | |
| D | ASN81 | |
| D | SER265 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | GLY184 | |
| B | GLY184 | |
| C | GLY184 | |
| D | GLY184 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000305 |
| Chain | Residue | Details |
| A | ARG220 | |
| B | ARG220 | |
| C | ARG220 | |
| D | ARG220 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-(pyridoxal phosphate)lysine |
| Chain | Residue | Details |
| A | LYS51 | |
| B | LYS51 | |
| C | LYS51 | |
| D | LYS51 |
