5I7F
Crystal structure of B. pseudomallei FabI in complex with NAD and PT405
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| D | 0006633 | biological_process | fatty acid biosynthetic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| E | 0006633 | biological_process | fatty acid biosynthetic process |
| E | 0016491 | molecular_function | oxidoreductase activity |
| F | 0000166 | molecular_function | nucleotide binding |
| F | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| F | 0006633 | biological_process | fatty acid biosynthetic process |
| F | 0016491 | molecular_function | oxidoreductase activity |
| G | 0000166 | molecular_function | nucleotide binding |
| G | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| G | 0006633 | biological_process | fatty acid biosynthetic process |
| G | 0016491 | molecular_function | oxidoreductase activity |
| H | 0000166 | molecular_function | nucleotide binding |
| H | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| H | 0006633 | biological_process | fatty acid biosynthetic process |
| H | 0016491 | molecular_function | oxidoreductase activity |
| I | 0000166 | molecular_function | nucleotide binding |
| I | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| I | 0006633 | biological_process | fatty acid biosynthetic process |
| I | 0016491 | molecular_function | oxidoreductase activity |
| J | 0000166 | molecular_function | nucleotide binding |
| J | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| J | 0006633 | biological_process | fatty acid biosynthetic process |
| J | 0016491 | molecular_function | oxidoreductase activity |
| K | 0000166 | molecular_function | nucleotide binding |
| K | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| K | 0006633 | biological_process | fatty acid biosynthetic process |
| K | 0016491 | molecular_function | oxidoreductase activity |
| L | 0000166 | molecular_function | nucleotide binding |
| L | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| L | 0006633 | biological_process | fatty acid biosynthetic process |
| L | 0016491 | molecular_function | oxidoreductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue NAD B 301 |
| Chain | Residue |
| B | GLY13 |
| B | ILE92 |
| B | GLY93 |
| B | ILE119 |
| B | LEU144 |
| B | SER145 |
| B | LYS163 |
| B | ALA189 |
| B | GLY190 |
| B | PRO191 |
| B | ILE192 |
| B | LEU15 |
| B | THR194 |
| B | LEU195 |
| B | ALA196 |
| B | 68O302 |
| B | SER19 |
| B | ILE20 |
| B | VAL40 |
| B | CYS63 |
| B | ASP64 |
| B | VAL65 |
| B | SER91 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue 68O B 302 |
| Chain | Residue |
| B | GLY93 |
| B | ILE100 |
| B | TYR156 |
| B | MET159 |
| B | ALA196 |
| B | ALA197 |
| B | PHE203 |
| B | NAD301 |
| site_id | AC3 |
| Number of Residues | 24 |
| Details | binding site for residue NAD E 301 |
| Chain | Residue |
| E | GLY13 |
| E | LEU15 |
| E | SER19 |
| E | ILE20 |
| E | VAL40 |
| E | CYS63 |
| E | ASP64 |
| E | VAL65 |
| E | SER91 |
| E | ILE92 |
| E | GLY93 |
| E | PHE94 |
| E | ILE119 |
| E | LEU144 |
| E | SER145 |
| E | LYS163 |
| E | ALA189 |
| E | GLY190 |
| E | PRO191 |
| E | ILE192 |
| E | THR194 |
| E | ALA196 |
| E | 68O302 |
| E | HOH407 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue 68O E 302 |
| Chain | Residue |
| E | GLY93 |
| E | TYR146 |
| E | TYR156 |
| E | MET159 |
| E | PRO191 |
| E | ALA196 |
| E | ALA197 |
| E | ILE200 |
| E | PHE203 |
| E | NAD301 |
| site_id | AC5 |
| Number of Residues | 21 |
| Details | binding site for residue NAD H 301 |
| Chain | Residue |
| H | GLY13 |
| H | LEU15 |
| H | SER19 |
| H | ILE20 |
| H | VAL40 |
| H | CYS63 |
| H | ASP64 |
| H | VAL65 |
| H | SER91 |
| H | ILE92 |
| H | GLY93 |
| H | LEU144 |
| H | SER145 |
| H | LYS163 |
| H | ALA189 |
| H | GLY190 |
| H | PRO191 |
| H | ILE192 |
| H | THR194 |
| H | ALA196 |
| H | 68O302 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | binding site for residue 68O H 302 |
| Chain | Residue |
| H | GLY93 |
| H | PHE94 |
| H | ILE100 |
| H | TYR146 |
| H | TYR156 |
| H | MET159 |
| H | ALA196 |
| H | ALA197 |
| H | ILE200 |
| H | PHE203 |
| H | NAD301 |
| site_id | AC7 |
| Number of Residues | 23 |
| Details | binding site for residue NAD C 301 |
| Chain | Residue |
| C | SER19 |
| C | ILE20 |
| C | VAL40 |
| C | CYS63 |
| C | ASP64 |
| C | VAL65 |
| C | SER91 |
| C | ILE92 |
| C | GLY93 |
| C | ILE119 |
| C | LEU144 |
| C | SER145 |
| C | TYR146 |
| C | LYS163 |
| C | ALA189 |
| C | GLY190 |
| C | PRO191 |
| C | ILE192 |
| C | THR194 |
| C | ALA196 |
| C | 68O302 |
| C | GLY13 |
| C | LEU15 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | binding site for residue 68O C 302 |
| Chain | Residue |
| C | GLY93 |
| C | PHE94 |
| C | ILE100 |
| C | TYR146 |
| C | TYR156 |
| C | MET159 |
| C | ALA196 |
| C | ALA197 |
| C | ILE200 |
| C | PHE203 |
| C | NAD301 |
| site_id | AC9 |
| Number of Residues | 22 |
| Details | binding site for residue NAD A 301 |
| Chain | Residue |
| A | GLY13 |
| A | LEU15 |
| A | SER19 |
| A | ILE20 |
| A | VAL40 |
| A | CYS63 |
| A | ASP64 |
| A | VAL65 |
| A | SER91 |
| A | ILE92 |
| A | GLY93 |
| A | LEU144 |
| A | SER145 |
| A | LYS163 |
| A | ALA189 |
| A | GLY190 |
| A | PRO191 |
| A | ILE192 |
| A | THR194 |
| A | LEU195 |
| A | ALA196 |
| A | 68O302 |
| site_id | AD1 |
| Number of Residues | 9 |
| Details | binding site for residue 68O A 302 |
| Chain | Residue |
| A | GLY93 |
| A | PHE94 |
| A | TYR146 |
| A | TYR156 |
| A | ALA196 |
| A | ALA197 |
| A | ILE200 |
| A | PHE203 |
| A | NAD301 |
| site_id | AD2 |
| Number of Residues | 22 |
| Details | binding site for residue NAD F 301 |
| Chain | Residue |
| F | GLY13 |
| F | LEU15 |
| F | SER19 |
| F | ILE20 |
| F | VAL40 |
| F | CYS63 |
| F | ASP64 |
| F | VAL65 |
| F | SER91 |
| F | ILE92 |
| F | GLY93 |
| F | LEU144 |
| F | SER145 |
| F | LYS163 |
| F | ALA189 |
| F | GLY190 |
| F | PRO191 |
| F | ILE192 |
| F | THR194 |
| F | LEU195 |
| F | ALA196 |
| F | 68O302 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue 68O F 302 |
| Chain | Residue |
| F | GLY93 |
| F | TYR146 |
| F | TYR156 |
| F | MET159 |
| F | ALA196 |
| F | ALA197 |
| F | PHE203 |
| F | NAD301 |
| site_id | AD4 |
| Number of Residues | 22 |
| Details | binding site for residue NAD G 301 |
| Chain | Residue |
| G | GLY13 |
| G | LEU15 |
| G | SER19 |
| G | ILE20 |
| G | VAL40 |
| G | CYS63 |
| G | ASP64 |
| G | VAL65 |
| G | SER91 |
| G | ILE92 |
| G | GLY93 |
| G | ILE119 |
| G | LEU144 |
| G | SER145 |
| G | LYS163 |
| G | ALA189 |
| G | GLY190 |
| G | PRO191 |
| G | ILE192 |
| G | THR194 |
| G | ALA196 |
| G | 68O302 |
| site_id | AD5 |
| Number of Residues | 9 |
| Details | binding site for residue 68O G 302 |
| Chain | Residue |
| G | GLY93 |
| G | ILE100 |
| G | TYR146 |
| G | TYR156 |
| G | MET159 |
| G | ALA196 |
| G | ALA197 |
| G | PHE203 |
| G | NAD301 |
| site_id | AD6 |
| Number of Residues | 21 |
| Details | binding site for residue NAD D 301 |
| Chain | Residue |
| D | GLY13 |
| D | LEU15 |
| D | SER19 |
| D | ILE20 |
| D | VAL40 |
| D | CYS63 |
| D | ASP64 |
| D | VAL65 |
| D | SER91 |
| D | ILE92 |
| D | GLY93 |
| D | ILE119 |
| D | SER145 |
| D | LYS163 |
| D | ALA189 |
| D | GLY190 |
| D | PRO191 |
| D | ILE192 |
| D | THR194 |
| D | ALA196 |
| D | 68O302 |
| site_id | AD7 |
| Number of Residues | 9 |
| Details | binding site for residue 68O D 302 |
| Chain | Residue |
| D | GLY93 |
| D | TYR146 |
| D | TYR156 |
| D | MET159 |
| D | ALA196 |
| D | ALA197 |
| D | ILE200 |
| D | PHE203 |
| D | NAD301 |
| site_id | AD8 |
| Number of Residues | 22 |
| Details | binding site for residue NAD I 301 |
| Chain | Residue |
| I | GLY13 |
| I | LEU15 |
| I | SER19 |
| I | ILE20 |
| I | VAL40 |
| I | CYS63 |
| I | ASP64 |
| I | VAL65 |
| I | SER91 |
| I | ILE92 |
| I | GLY93 |
| I | ILE119 |
| I | SER145 |
| I | LYS163 |
| I | ALA189 |
| I | GLY190 |
| I | PRO191 |
| I | ILE192 |
| I | THR194 |
| I | LEU195 |
| I | ALA196 |
| I | 68O302 |
| site_id | AD9 |
| Number of Residues | 8 |
| Details | binding site for residue 68O I 302 |
| Chain | Residue |
| I | GLY93 |
| I | PHE94 |
| I | TYR156 |
| I | MET159 |
| I | ALA196 |
| I | ALA197 |
| I | PHE203 |
| I | NAD301 |
| site_id | AE1 |
| Number of Residues | 23 |
| Details | binding site for residue NAD K 301 |
| Chain | Residue |
| K | GLY13 |
| K | LEU15 |
| K | SER19 |
| K | ILE20 |
| K | VAL40 |
| K | CYS63 |
| K | ASP64 |
| K | VAL65 |
| K | SER91 |
| K | ILE92 |
| K | GLY93 |
| K | ILE119 |
| K | LEU144 |
| K | SER145 |
| K | LYS163 |
| K | ALA189 |
| K | GLY190 |
| K | PRO191 |
| K | ILE192 |
| K | THR194 |
| K | ALA196 |
| K | 68O302 |
| K | HOH409 |
| site_id | AE2 |
| Number of Residues | 9 |
| Details | binding site for residue 68O K 302 |
| Chain | Residue |
| K | GLY93 |
| K | TYR146 |
| K | TYR156 |
| K | MET159 |
| K | PRO191 |
| K | ALA196 |
| K | ALA197 |
| K | PHE203 |
| K | NAD301 |
| site_id | AE3 |
| Number of Residues | 23 |
| Details | binding site for residue NAD L 301 |
| Chain | Residue |
| L | GLY13 |
| L | LEU15 |
| L | SER19 |
| L | ILE20 |
| L | VAL40 |
| L | CYS63 |
| L | ASP64 |
| L | VAL65 |
| L | SER91 |
| L | ILE92 |
| L | GLY93 |
| L | ILE119 |
| L | LEU144 |
| L | SER145 |
| L | TYR146 |
| L | LYS163 |
| L | ALA189 |
| L | GLY190 |
| L | PRO191 |
| L | ILE192 |
| L | THR194 |
| L | ALA196 |
| L | 68O302 |
| site_id | AE4 |
| Number of Residues | 10 |
| Details | binding site for residue 68O L 302 |
| Chain | Residue |
| L | GLY93 |
| L | PHE94 |
| L | ILE100 |
| L | TYR146 |
| L | TYR156 |
| L | MET159 |
| L | ALA196 |
| L | ALA197 |
| L | PHE203 |
| L | NAD301 |
| site_id | AE5 |
| Number of Residues | 24 |
| Details | binding site for residue NAD J 301 |
| Chain | Residue |
| J | GLY13 |
| J | LEU15 |
| J | SER19 |
| J | ILE20 |
| J | VAL40 |
| J | CYS63 |
| J | ASP64 |
| J | VAL65 |
| J | SER91 |
| J | ILE92 |
| J | GLY93 |
| J | ILE119 |
| J | LEU144 |
| J | SER145 |
| J | LYS163 |
| J | ALA189 |
| J | GLY190 |
| J | PRO191 |
| J | ILE192 |
| J | THR194 |
| J | LEU195 |
| J | ALA196 |
| J | 68O302 |
| J | HOH409 |
| site_id | AE6 |
| Number of Residues | 7 |
| Details | binding site for residue 68O J 302 |
| Chain | Residue |
| J | TYR146 |
| J | TYR156 |
| J | ALA196 |
| J | ALA197 |
| J | ILE200 |
| J | PHE203 |
| J | NAD301 |
