5I5C
X-ray crystal structure of allo-Thr31-ShK
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0015459 | molecular_function | potassium channel regulator activity |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0042151 | cellular_component | nematocyst |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0090729 | molecular_function | toxin activity |
| A | 0099106 | molecular_function | ion channel regulator activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0015459 | molecular_function | potassium channel regulator activity |
| B | 0035821 | biological_process | modulation of process of another organism |
| B | 0042151 | cellular_component | nematocyst |
| B | 0042742 | biological_process | defense response to bacterium |
| B | 0090729 | molecular_function | toxin activity |
| B | 0099106 | molecular_function | ion channel regulator activity |
| C | 0005576 | cellular_component | extracellular region |
| C | 0015459 | molecular_function | potassium channel regulator activity |
| C | 0035821 | biological_process | modulation of process of another organism |
| C | 0042151 | cellular_component | nematocyst |
| C | 0042742 | biological_process | defense response to bacterium |
| C | 0090729 | molecular_function | toxin activity |
| C | 0099106 | molecular_function | ion channel regulator activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue SO4 A 101 |
| Chain | Residue |
| A | ARG1 |
| C | PHE15 |
| C | HOH216 |
| A | LYS22 |
| A | SER26 |
| A | HOH205 |
| A | HOH222 |
| A | HOH234 |
| B | HOH229 |
| C | THR13 |
| C | ALA14 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 102 |
| Chain | Residue |
| A | THR13 |
| A | HOH201 |
| A | HOH211 |
| A | HOH228 |
| B | ARG1 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 103 |
| Chain | Residue |
| A | SER20 |
| A | MET21 |
| A | LYS22 |
| A | HOH202 |
| A | HOH239 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue LI B 101 |
| Chain | Residue |
| B | CYS12 |
| B | THR13 |
| B | GLN16 |
| B | CYS17 |
| B | CYS28 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 C 101 |
| Chain | Residue |
| C | SER20 |
| C | MET21 |
| C | LYS22 |
| C | HOH202 |
| C | HOH223 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 102 |
| Chain | Residue |
| C | ARG11 |
| C | GLN16 |
| C | TYR23 |
| C | HOH203 |
| C | HOH209 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue LI C 103 |
| Chain | Residue |
| C | CYS12 |
| C | THR13 |
| C | GLN16 |
| C | CYS17 |
| C | TYR23 |
| C | CYS28 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 15 |
| Details | Site: {"description":"Important residue for binding Kv1.3/KCNA3","evidences":[{"source":"PubMed","id":"26288216","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Site: {"description":"Important residue for binding Kv1.3/KCNA3","evidences":[{"source":"PubMed","id":"8645244","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Site: {"description":"Important residue for binding Kv1.3/KCNA3","evidences":[{"source":"PubMed","id":"26288216","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8645244","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Site: {"description":"Key residue for binding both Kv1.2/KCNA2 and Kv1.3/KCNA3 (occludes the channel pore like a cork in a bottle)","evidences":[{"source":"PubMed","id":"26288216","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8645244","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
