5I5B
quasi racemic structure of allo-Thr13-ShK and D-ShK
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0015459 | molecular_function | potassium channel regulator activity |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0042151 | cellular_component | nematocyst |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0090729 | molecular_function | toxin activity |
| A | 0099106 | molecular_function | ion channel regulator activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 101 |
| Chain | Residue |
| A | SER20 |
| A | MET21 |
| A | LYS22 |
| B | DAR11 |
| B | DAR29 |
| B | HOH215 |
| B | HOH240 |
| B | HOH241 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 102 |
| Chain | Residue |
| A | ARG24 |
| A | HOH203 |
| A | HOH208 |
| A | HOH230 |
| B | DLY18 |
| A | ARG1 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 103 |
| Chain | Residue |
| A | PRO8 |
| A | LYS9 |
| A | SER10 |
| A | PHE15 |
| A | HOH201 |
| A | HOH247 |
| B | HOH233 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue LI A 104 |
| Chain | Residue |
| A | TYR23 |
| A | HOH207 |
| B | DTH6 |
| B | DIL7 |
| B | DHI19 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue LI A 105 |
| Chain | Residue |
| A | ARG11 |
| A | HOH240 |
| A | HOH244 |
| B | GOL102 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 B 101 |
| Chain | Residue |
| A | ARG11 |
| A | ARG29 |
| A | HOH221 |
| A | HOH236 |
| A | HOH240 |
| A | HOH248 |
| B | DSN20 |
| B | MED21 |
| B | DLY22 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 102 |
| Chain | Residue |
| A | SER2 |
| A | THR6 |
| A | MET21 |
| A | LI105 |
| A | HOH213 |
| A | HOH218 |
| B | HOH206 |
| B | HOH213 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue LI B 103 |
| Chain | Residue |
| B | DSN2 |
| B | DCY3 |
| B | DCY35 |
| B | HOH226 |
| B | HOH247 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | Site: {"description":"Important residue for binding Kv1.3/KCNA3","evidences":[{"source":"PubMed","id":"26288216","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important residue for binding Kv1.3/KCNA3","evidences":[{"source":"PubMed","id":"8645244","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important residue for binding Kv1.3/KCNA3","evidences":[{"source":"PubMed","id":"26288216","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8645244","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Key residue for binding both Kv1.2/KCNA2 and Kv1.3/KCNA3 (occludes the channel pore like a cork in a bottle)","evidences":[{"source":"PubMed","id":"26288216","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8645244","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
