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5I5A

quasi racemic structure of allo-Ile7-ShK and D-ShK

Functional Information from GO Data
ChainGOidnamespacecontents
A0005576cellular_componentextracellular region
A0015459molecular_functionpotassium channel regulator activity
A0035821biological_processmodulation of process of another organism
A0042151cellular_componentnematocyst
A0042742biological_processdefense response to bacterium
A0090729molecular_functiontoxin activity
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue GOL A 101
ChainResidue
ASER20
AMET21
ALYS22
AHOH213
BDAR1
BDSN2
BHOH220

site_idAC2
Number of Residues9
Detailsbinding site for residue GOL A 102
ChainResidue
ASER2
ALEU25
AARG29
AHOH207
AHOH223
BDSN20
BMED21
AARG1
AARG1

site_idAC3
Number of Residues5
Detailsbinding site for residue NA A 103
ChainResidue
AASP5
APRO8
ALYS9
ASER10
AHOH214

site_idAC4
Number of Residues4
Detailsbinding site for residue LI A 104
ChainResidue
AARG24
ALEU25
BGLY33
BHOH214

site_idAC5
Number of Residues9
Detailsbinding site for residue MLT B 101
ChainResidue
AARG11
ATHR13
AGLN16
ATYR23
BDAR11
BDTH13
BDGN16
BDTY23
BHOH204

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues5
DetailsSITE: Important residue for binding Kv1.3/KCNA3 => ECO:0000269|PubMed:26288216
ChainResidueDetails
AILE7
ASER20
AMET21
ATYR23
APHE27

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Important residue for binding Kv1.3/KCNA3 => ECO:0000269|PubMed:8645244
ChainResidueDetails
ALYS9

site_idSWS_FT_FI3
Number of Residues1
DetailsSITE: Important residue for binding Kv1.3/KCNA3 => ECO:0000269|PubMed:26288216, ECO:0000269|PubMed:8645244
ChainResidueDetails
AARG11

site_idSWS_FT_FI4
Number of Residues1
DetailsSITE: Key residue for binding both Kv1.2/KCNA2 and Kv1.3/KCNA3 (occludes the channel pore like a cork in a bottle) => ECO:0000269|PubMed:26288216, ECO:0000269|PubMed:8645244
ChainResidueDetails
ALYS22

226707

PDB entries from 2024-10-30

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