5I58
GLUTAMATE- AND GLYCINE-BOUND GLUN1/GLUN2A AGONIST BINDING DOMAINS WITH MPX-004
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue GLY A 1001 |
| Chain | Residue |
| A | PHE92 |
| A | PRO124 |
| A | LEU125 |
| A | THR126 |
| A | ARG131 |
| A | SER180 |
| A | TRP223 |
| A | ASP224 |
| A | PHE250 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue GLU B 301 |
| Chain | Residue |
| B | HIS88 |
| B | SER114 |
| B | LEU115 |
| B | THR116 |
| B | ARG121 |
| B | GLY172 |
| B | SER173 |
| B | THR174 |
| B | TYR214 |
| B | ASP215 |
| B | HOH522 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue 67R B 302 |
| Chain | Residue |
| A | ILE127 |
| A | PRO140 |
| A | ARG247 |
| A | SER248 |
| A | GLY249 |
| A | HOH1101 |
| A | HOH1111 |
| B | VAL129 |
| B | PRO130 |
| B | PHE131 |
| B | VAL132 |
| B | GLU133 |
| B | LEU264 |
| B | VAL267 |
| B | MET272 |
| B | GLU276 |
| B | HOH532 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16281028, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8, ECO:0007744|PDB:5I56, ECO:0007744|PDB:5I57, ECO:0007744|PDB:5I58, ECO:0007744|PDB:5I59, ECO:0007744|PDB:5JTY |
| Chain | Residue | Details |
| B | SER114 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16281028, ECO:0000269|PubMed:24462099, ECO:0000269|PubMed:27618671, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8, ECO:0007744|PDB:5I56, ECO:0007744|PDB:5I57, ECO:0007744|PDB:5I58, ECO:0007744|PDB:5I59, ECO:0007744|PDB:5JTY |
| Chain | Residue | Details |
| B | ARG121 | |
| A | ILE159 | |
| A | TYR203 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16281028, ECO:0000269|PubMed:24462099, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8 |
| Chain | Residue | Details |
| B | SER173 | |
| B | TYR214 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN46 | |
| B | ASN47 | |
| B | ASN171 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0007744|PubMed:24090084 |
| Chain | Residue | Details |
| A | GLY242 |
