5I4Y

Exploring onset of lysozyme denaturation by urea: soak period 10 hours.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0003824	molecular_function	catalytic activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005794	cellular_component	Golgi apparatus
A	0016231	molecular_function	beta-N-acetylglucosaminidase activity
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016998	biological_process	cell wall macromolecule catabolic process
A	0031640	biological_process	killing of cells of another organism
A	0042742	biological_process	defense response to bacterium
A	0042802	molecular_function	identical protein binding
A	0050829	biological_process	defense response to Gram-negative bacterium
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0051672	biological_process	obsolete catabolism by organism of cell wall peptidoglycan in other organism

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue URE A 201

Chain	Residue
A	ALA10
A	ALA10
A	ARG14
A	ARG14
A	LEU129
A	LEU129

---

site_id	AC2
Number of Residues	7
Details	binding site for residue URE A 202

Chain	Residue
A	ARG45
A	ARG68
A	HOH374
A	HOH374
A	THR43
A	THR43
A	ARG45

---

site_id	AC3
Number of Residues	3
Details	binding site for residue URE A 203

Chain	Residue
A	CYS6
A	ARG128
A	HOH355

---

site_id	AC4
Number of Residues	5
Details	binding site for residue URE A 204

Chain	Residue
A	ARG61
A	ILE124
A	CYS127
A	LEU129
A	HOH367

---

site_id	AC5
Number of Residues	6
Details	binding site for residue URE A 205

Chain	Residue
A	ASN65
A	GLY67
A	ARG68
A	THR69
A	SER72
A	HOH330

---

site_id	AC6
Number of Residues	7
Details	binding site for residue URE A 206

Chain	Residue
A	GLN57
A	ILE58
A	ASN59
A	TRP63
A	ALA107
A	TRP108
A	URE209

---

site_id	AC7
Number of Residues	6
Details	binding site for residue URE A 207

Chain	Residue
A	PHE34
A	TRP111
A	ARG114
A	GLY117
A	URE211
A	URE216

---

site_id	AC8
Number of Residues	6
Details	binding site for residue URE A 208

Chain	Residue
A	LYS13
A	PRO70
A	PRO70
A	HOH360
A	HOH365
A	HOH367

---

site_id	AC9
Number of Residues	9
Details	binding site for residue URE A 209

Chain	Residue
A	GLU35
A	ASP52
A	GLN57
A	ALA107
A	TRP108
A	VAL109
A	URE206
A	HOH334
A	HOH352

---

site_id	AD1
Number of Residues	4
Details	binding site for residue URE A 210

Chain	Residue
A	ASN37
A	ASN39
A	GLY67
A	HOH370

---

site_id	AD2
Number of Residues	7
Details	binding site for residue URE A 211

Chain	Residue
A	ARG114
A	THR118
A	ASP119
A	TRP123
A	URE207
A	HOH313
A	HOH363

---

site_id	AD3
Number of Residues	4
Details	binding site for residue URE A 212

Chain	Residue
A	ARG21
A	ASN46
A	THR47
A	URE214

---

site_id	AD4
Number of Residues	4
Details	binding site for residue URE A 213

Chain	Residue
A	LYS33
A	URE221
A	HOH301
A	HOH335

---

site_id	AD5
Number of Residues	7
Details	binding site for residue URE A 214

Chain	Residue
A	ARG21
A	ARG45
A	ASN46
A	ASP52
A	URE212
A	HOH311
A	HOH346

---

site_id	AD6
Number of Residues	4
Details	binding site for residue URE A 215

Chain	Residue
A	LYS33
A	PHE38
A	CL222
A	HOH371

---

site_id	AD7
Number of Residues	7
Details	binding site for residue URE A 216

Chain	Residue
A	ASN27
A	ARG114
A	THR118
A	VAL120
A	URE207
A	URE221
A	HOH301

---

site_id	AD8
Number of Residues	5
Details	binding site for residue URE A 217

Chain	Residue
A	ARG45
A	GLY49
A	URE219
A	HOH306
A	HOH377

---

site_id	AD9
Number of Residues	4
Details	binding site for residue URE A 218

Chain	Residue
A	HOH312
A	HOH348
A	ARG5
A	CYS6

---

site_id	AE1
Number of Residues	9
Details	binding site for residue URE A 219

Chain	Residue
A	GLY16
A	ASP18
A	ASN19
A	TYR20
A	ARG45
A	URE217
A	HOH305
A	HOH318
A	HOH368

---

site_id	AE2
Number of Residues	5
Details	binding site for residue URE A 220

Chain	Residue
A	ASN19
A	GLY22
A	PHE34
A	GLU35
A	URE221

---

site_id	AE3
Number of Residues	10
Details	binding site for residue URE A 221

Chain	Residue
A	GLY22
A	TYR23
A	SER24
A	ASN27
A	ARG114
A	URE213
A	URE216
A	URE220
A	HOH301
A	HOH303

---

site_id	AE4
Number of Residues	2
Details	binding site for residue CL A 222

Chain	Residue
A	ARG5
A	URE215

---

Functional Information from PROSITE/UniProt

site_id	PS00128
Number of Residues	19
Details	GLYCOSYL_HYDROL_F22_1 Glycosyl hydrolases family 22 (GH22) domain signature. CnipCsaLlssDItasvnC

Chain	Residue	Details
A	CYS76-CYS94

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	128
Details	Domain: {"description":"C-type lysozyme","evidences":[{"source":"PROSITE-ProRule","id":"PRU00680","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 203

Chain	Residue	Details
A	GLU35	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	ASN46
A	ASP48
A	SER50
A	ASP52	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction
A	ASN59

---