5I4V

Discovery of novel, orally efficacious Liver X Receptor (LXR) beta agonists

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0006629	biological_process	lipid metabolic process
B	0003677	molecular_function	DNA binding
B	0003707	molecular_function	nuclear steroid receptor activity
B	0005634	cellular_component	nucleus
B	0006355	biological_process	regulation of DNA-templated transcription
B	0008270	molecular_function	zinc ion binding
E	0003677	molecular_function	DNA binding
E	0004879	molecular_function	nuclear receptor activity
E	0006629	biological_process	lipid metabolic process
F	0003677	molecular_function	DNA binding
F	0003707	molecular_function	nuclear steroid receptor activity
F	0005634	cellular_component	nucleus
F	0006355	biological_process	regulation of DNA-templated transcription
F	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue 67S A 501

Chain	Residue
A	PHE268
A	PHE329
A	LEU330
A	LEU345
A	HIS435
A	HOH601
A	PHE271
A	THR272
A	LEU274
A	SER278
A	GLU281
A	MET312
A	THR316
A	ARG319

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site_id	AC2
Number of Residues	14
Details	binding site for residue 67S E 501

Chain	Residue
E	PHE268
E	PHE271
E	THR272
E	LEU274
E	SER278
E	GLU281
E	MET312
E	THR316
E	PHE329
E	LEU330
E	PHE340
E	LEU345
E	HIS435
E	LEU449

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
B	SER547
F	SER547
A	LYS448
E	LYS410
E	LYS448

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER480
E	SER480

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