Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0004879 | molecular_function | nuclear receptor activity |
| A | 0006629 | biological_process | lipid metabolic process |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003707 | molecular_function | nuclear steroid receptor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0008270 | molecular_function | zinc ion binding |
| E | 0003677 | molecular_function | DNA binding |
| E | 0004879 | molecular_function | nuclear receptor activity |
| E | 0006629 | biological_process | lipid metabolic process |
| F | 0003677 | molecular_function | DNA binding |
| F | 0003707 | molecular_function | nuclear steroid receptor activity |
| F | 0005634 | cellular_component | nucleus |
| F | 0006355 | biological_process | regulation of DNA-templated transcription |
| F | 0008270 | molecular_function | zinc ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue 67S A 501 |
| Chain | Residue |
| A | PHE268 |
| A | PHE329 |
| A | LEU330 |
| A | LEU345 |
| A | HIS435 |
| A | HOH601 |
| A | PHE271 |
| A | THR272 |
| A | LEU274 |
| A | SER278 |
| A | GLU281 |
| A | MET312 |
| A | THR316 |
| A | ARG319 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue 67S E 501 |
| Chain | Residue |
| E | PHE268 |
| E | PHE271 |
| E | THR272 |
| E | LEU274 |
| E | SER278 |
| E | GLU281 |
| E | MET312 |
| E | THR316 |
| E | PHE329 |
| E | LEU330 |
| E | PHE340 |
| E | LEU345 |
| E | HIS435 |
| E | LEU449 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 238 |
| Details | Domain: {"description":"NR LBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01189","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 241 |
| Details | Region: {"description":"Transactivation AF-2; required for ligand-dependent transactivation function; mediates interaction with CCAR2","evidences":[{"source":"PubMed","id":"25661920","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"20159957","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Motif: {"description":"LXXLL motif 1"} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 16 |
| Details | Motif: {"description":"LXXLL motif 2"} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | Compositional bias: {"description":"Low complexity","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q61026","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
